Results 81 to 90 of about 1,190,922 (296)

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Acute febrile illness is associated with Rickettsia spp infection in dogs [PDF]

, 2015
BACKGROUND: Rickettsia conorii is transmitted by Rhipicephalus sanguineus ticks and causes Mediterranean Spotted Fever (MSF) in humans. Although dogs are considered the natural host of the vector, the clinical and epidemiological significance of R ...
A Cascio, A Estrada-Pena, A Mannelli, A Mura, A Ortuno, A Rojas, A Torina, A Torina, A Torina, A Znazen, Alessandra Caprì, AM Gasser, BA Stillman, C Colomba, C Riera, C Rovery, CP Ober, D Otranto, D Otranto, D Otranto, E Beeler, E Sanger, EB Breitschwerdt, F Segura-Porta, FJ Marquez, G Baneth, G Baneth, G Baneth, G Vitale, GB Andrade, GM Giammanco, GM Giammanco, H Inokuma, J Fuente de la, JC Garcia-Garcia, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, Laia Solano-Gallego, M Bernabeu-Wittel, M Rene-Martellet, M Sarih, Marco Caldin, Maria Grazia Pennisi, ME Eremeeva, ME Mylonakis, Michele Trotta, ML Levin, ML Levin, N Alexandre, N Cardenosa, NY Salem, P Brouqui, P Brouqui, P Parola, P Parola, PJ Kelly, S Delgado, S Harrus, S Harrus, S Santibanez, SE Little, T Beninati, T Furlanello, Tommaso Furlanello, WL Nicholson   +69 more
core   +3 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Early suppression of lymphoproliferative response in dogs with natural infection by Leishmania infantum. [PDF]

, 1999
Dogs are the domestic reservoirs of zoonotic visceral leishmaniasis caused by Leishmania infantum. Early detection of canine infections evolving to clinically patent disease may be important to leishmaniasis control.
CIARAMELLA, PAOLO, DE LUNA R., GRADONI L., IELPO M. T. L. AMBROSIO R., MANCINO D., MOSCATIELLO V., PIANTEDOSI, DIEGO, SCALONE A., VUOTTO M. L.   +8 more
core   +1 more source

Dog ownership satisfaction determinants in the owner-dog relationship and the dog's behaviour

PLOS ONE, 2018
Dog ownership satisfaction relates to the quality of life of both owner and dog, and when seriously compromised may even lead to dog abandonment. Knowledge on determinants of dog ownership satisfaction is limited, obstructing solutions for promoting satisfaction, and here we quantified causes making dog owners less than very satisfied with their dog ...
van Herwijnen, Ineke R., van der Borg, Joanne A.M., Naguib, Marc, Beerda, Bonne   +3 more
openaire   +6 more sources

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Effect of Repeated Intravenous Injections of Bilirubin on Erythropoiesis in Anaemic Dogs [PDF]

, 1940
R. R. Bomford
openalex   +1 more source

Eddington-Limited Accretion in z~2 WISE-selected Hot, Dust-Obscured Galaxies

, 2017
Hot, Dust-Obscured Galaxies, or "Hot DOGs", are a rare, dusty, hyperluminous galaxy population discovered by the WISE mission. Predominantly at redshifts 2-3, they include the most luminous known galaxies in the universe.
Aldering, Greg, Assef, Roberto J., Blain, Andrew, Boone, Kyle, Denney, Kelly D., Díaz-Santos, Tanio, Eisenhardt, Peter R. M., Fagrelius, Parker, Hayden, Brian T., Jun, Hyunsung D., Perlmutter, Saul, Stern, Daniel, Tsai, Chao-Wei, Wright, Edward L., Wu, Jingwen   +14 more
core   +1 more source

Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias. [PDF]

, 2018
BackgroundSotalol is a commonly used antiarrhythmic drug that may alter ventricular function.ObjectiveTo determine the effect of sotalol on echocardiographic indices of ventricular systolic function in dogs with ventricular arrhythmias.AnimalsThirty-five
Anderson, Baumwart, Chetboul, Cornell, Dukes-McEwan, Hansson, Hoffmann, Hohnloser, Kaye, Mahmarian, Maran, Martin, Meurs, Meurs, Meurs, Meurs, Motskula, Oyama, Palermo, Peralta, Schnelle, Seidler, Singh, Smets, Stephenson, Summerfield, Visser, Visser, Wess, Wess, Zupan   +30 more
core   +2 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source