Results 221 to 230 of about 18,832,580 (328)

Insights into therapeutic discovery through the Kelch domain structure of Keap1 at ambient temperature. [PDF]

Turk J Biol
Yilmaz M, Sever B, Kutlu Y, Gül M, Okuducu C, Tavli S, Otsuka M, Fujita M, Haliloğlu T, Çiftçi H, Demirci H.   +10 more
europepmc   +1 more source

Missense Mutations in Desmoplakin Plakin Repeat Domains Have Dramatic Effects on Domain Structure and Function. [PDF]

Int J Mol Sci, 2022
Mohammed F, Odintsova E, Chidgey M.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Constructing a Broad-Pore-Domain Structure of Adsorbents for Acteoside Adsorption. [PDF]

Polymers (Basel)
Ru W, Liu J, Xiong F, Sun Y, Zhang Y, Li Y, Lv Y, Li X.   +7 more
europepmc   +1 more source

Contribution of domain structure to the function of the yeast DEDD family exoribonuclease and RNase T functional homolog, Rex1. [PDF]

RNA, 2022
Daniels PW, Hama Soor T, Levicky Q, Hettema EH, Mitchell P.   +4 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The androgen receptor amino-terminal domain: structure, function and therapeutic potential. [PDF]

Endocr Oncol
Hunter I, Jamieson C, McEwan IJ.
europepmc   +1 more source

A Scalable Network Model for Electrically Tunable Ferroelectric Domain Structure in Twistronic Bilayers of Two-Dimensional Semiconductors. [PDF]

Nano Lett, 2022
Enaldiev VV, Ferreira F, Fal'ko VI.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Unraveling Desmin's Head Domain Structure and Function. [PDF]

Cells
Vlachakis D, Tsilafakis K, Kostavasili I, Kossida S, Mavroidis M.   +4 more
europepmc   +1 more source