GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production [PDF]
Scientific Reports, 2023 GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution.
Aline Sandouk +8 more
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Domain swapping: a mathematical model for quantitative assessment of structural effects [PDF]
FEBS Open BioThe domain‐swapping mechanism involves the exchange of structural elements within a secondary or supersecondary structure between two (or more) proteins.
Irena Roterman +3 more
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Domain-swapped dimer of Pseudomonas aeruginosa cytochrome c551: structural insights into domain swapping of cytochrome c family proteins. [PDF]
PLoS ONE, 2015 Cytochrome c (cyt c) family proteins, such as horse cyt c, Pseudomonas aeruginosa cytochrome c551 (PA cyt c551), and Hydrogenobacter thermophilus cytochrome c552 (HT cyt c552), have been used as model proteins to study the relationship between the ...
Satoshi Nagao +7 more
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The enigma of the near-symmetry of proteins: Domain swapping. [PDF]
PLoS ONE, 2017 The majority of proteins form oligomers which have rotational symmetry. Literature has suggested many functional advantages that the symmetric packing offers. Yet, despite these advantages, the vast majority of protein oligomers are only nearly symmetric.
Maayan Bonjack-Shterengartz, David Avnir
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Energetic Calculations to Decipher pH-Dependent Oligomerization and Domain Swapping of Proteins. [PDF]
PLoS ONE, 2015 Domain swapping mechanism is a specialised mode of oligomerization of proteins in which part of a protein is exchanged in a non-covalent manner between constituent subunits. This mechanism is highly affected by several physiological conditions.
Prashant Shingate +2 more
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A five-residue motif for the design of domain swapping in proteins [PDF]
Nature Communications, 2019 Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and ...
Neha Nandwani +6 more
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Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris [PDF]
AMB Express, 2019 Easy preparation of chimeric nanobodies with various scaffolds is important for customizing abilities of nanobodies toward practical utilization. To accomplish high-throughput production of various nanobodies, utilization of microbes is an attractive ...
Natsuko Miura +7 more
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Genome-Wide Prediction and Analysis of 3D-Domain Swapped Proteins in the Human Genome from Sequence Information. [PDF]
PLoS ONE, 2016 3D-domain swapping is one of the mechanisms of protein oligomerization and the proteins exhibiting this phenomenon have many biological functions. These proteins, which undergo domain swapping, have acquired much attention owing to their involvement in ...
Atul Kumar Upadhyay +1 more
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Bioinformatics and Biology Insights, 2010 3-dimensional domain swapping is a mechanism where two or more protein molecules form higher order oligomers by exchanging identical or similar subunits. Recently, this phenomenon has received much attention in the context of prions and neurodegenerative
Khader Shameer +5 more
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Apoprotein Intermolecular Interactions and Heme Insertion for 3D Domain Swapping in Myoglobin [PDF]
ACS OmegaGissi Novientri +7 more
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