Results 91 to 100 of about 83,143 (263)

Novel Frequency Swapping Technique for Conducted Electromagnetic Interference Suppression in Power Converter Applications

Energies, 2016
Quasi-resonant flyback (QRF) converters have been widely applied as the main circuit topology in power converters because of their low cost and high efficiency.
Ming-Tse Kuo, Ming-Chang Tsou
doaj   +1 more source

Dynamic Decoration of DNA Scaffolds for High‐Resolution Cancer Cell Subtyping

Advanced Science, EarlyView.
This study presents a dual‐mode imaging platform that utilizes self‐assembly and disassembly of DNA scaffolds for high‐resolution cancer cell detection. The structural rigidity of DNA scaffolds effectively prevents cellular internalization for over 300 min.
Xiaolin Hu, Jie Xie, Xinlin Guo, Liangting Wang, Zhengheng Yu, Xiaopei Qiu, Heng Li, Kang Wang, Xiaoxing Wang, Mingxuan Song, Junsong Guo, Wei Gu, Sergio Bernardini, Chaoyong Yang, Hong Zhang, Yang Luo   +15 more
wiley   +1 more source

Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations

, 2012
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of protein stability while maintaining ...
Benkovic, Bershtein, Dams, DePristo, Ding, Dobson, Drummond, E. I. Shakhnovich, Elena, Fernandez, Gronenborn, Ispolatov, Lukatsky, Malevanets, Park, Parsell, Privalov, Privalov, Robertson, Rousseau, Rousseau, S. Bershtein, Shakhnovich, Soskine, Taniguchi, Taverna, W. Mu, Weinreich, Wright, Yang   +29 more
core   +1 more source

Protein acrobatics in pairs — dimerization via domain swapping [PDF]

Current Opinion in Structural Biology, 2009
Ever since Anfinsen’s seminal experiments about 50 years ago, it is widely accepted that the amino acid sequence of a protein determines its unique three-dimensional structure. While generally true for single chain proteins, in multimers, two or more individual chains can be assembled in different ways.
openaire   +2 more sources

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence

Angewandte Chemie, EarlyView.
This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe, Josef Wachtveitl, Alexander Heckel, Florian Buhr, Sabrina Toews, Thomas M. Schimmer   +5 more
wiley   +2 more sources

Swapping Space for Time: An Alternative to Time-Domain Interferometry

Frontiers in Physics, 2019
Young's double-slit experiment [1] requires two waves produced simultaneously at two different points in space. In quantum mechanics the waves correspond to a single quantum object, even as complex as a big molecule. An interference is present as long as
Marek Czachor
doaj   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Integration and exchange of split dCas9 domains for transcriptional controls in mammalian cells

Nature Communications, 2016
Molecular engineering of Cas9 has the potential to expand the application of CRISPR-Cas technology. Here, Ma et al. show that dCas9 can be split and reconstituted in human cells and use a domain swapping strategy to engineer custom Cas9-based logic ...
Dacheng Ma, Shuguang Peng, Zhen Xie
doaj   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source