Results 71 to 80 of about 1,858,101 (277)

The 25 kDa H_CN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity

Toxins, 2020
The extraordinarily potent clostridial neurotoxins (CNTs) comprise tetanus neurotoxin (TeNT) and the seven established botulinum neurotoxin serotypes (BoNT/A-G).
Julian Deppe, Jasmin Weisemann, Stefan Mahrhold, Andreas Rummel   +3 more
doaj   +1 more source

CirPred, the first structure modeling and linker design system for circularly permuted proteins

BMC Bioinformatics, 2021
Background This work aims to help develop new protein engineering techniques based on a structural rearrangement phenomenon called circular permutation (CP), equivalent to connecting the native termini of a protein followed by creating new termini at ...
Teng-Ruei Chen, Yen-Cheng Lin, Yu-Wei Huang, Chih-Chieh Chen, Wei-Cheng Lo   +4 more
doaj   +1 more source

BS‐RNase tetramers: An example of domain‐swapped oligomers [PDF]

FEBS Letters, 1996
In the ribonuclease superfamily, dimericity is a unique feature of bovine seminal RNase (BS‐RNase). In about two‐thirds of native BS‐RNase molecules, the two subunits interchange their N‐terminal tails, thus generating domain‐swapped dimers (MxM), which mostly responsible for enzyme biological activities and allostericity.
Adinolfi, S, Piccoli, R, Sica, F, Mazzarella, L   +3 more
openaire   +3 more sources

Surface Segregation in Compositionally Complex Ag‐Au‐Pd‐Pt Solid Solutions: Insights From High‐Throughput Experimentation and Atomistic Simulations

Advanced Materials Interfaces, EarlyView.
Surface segregation in quaternary Ag‐Au‐Pd‐Pt compositionally complex solid solutions is systematically mapped across 684 compositions by combining high‐throughput EDX and XPS characterization of co‐sputtered thin‐film libraries with large‐scale MD/MC atomistic simulations.
Ridha Zerdoumi, Felix Thelen, Quentin Bizot, Aleksander Kostka, Rico Zehl, Florian Lourens, Yanyan Liang, Matous Mrovec, Ralf Drautz, Wolfgang Schuhmann, Alfred Ludwig   +10 more
wiley   +1 more source

Programmable Pneumatic Actuator System for a Bioinspired Artificial Colon

Advanced Materials Technologies, EarlyView.
A modular soft robotic colon simulator driven by programmable pneumatic actuation is developed to mimic physiological and pathological‐like motility patterns of the large intestine. Finite element–guided design and distributed control enable anatomically realistic deformation for peristalsis, segmentation, and mass movements, supporting capsule ...
Andrew Bickerdike, Bo Tian, Xizheng Fang, Zepeng Wang, Yang Liu, Lucy Adams, Shyam Prasad   +6 more
wiley   +1 more source

Protein Domain-Swapping Can Be a Consequence of Functional Residues

, 2016
Monomer topology has been implicated in domain-swapping, a potential first step on the route to disease-causing protein aggregation. Despite having the same topology (β1-α1-β2-β3-β4-β5), the cysteine protease inhibitor stefin-B domain swaps more readily ...
Nahren Manuel Mascarenhas (2428174), Shachi Gosavi (160132)   +1 more
core   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Stability and Dynamics of Domain‐Swapped Bovine‐Seminal Ribonuclease [PDF]

Chemistry & Biodiversity, 2004
AbstractThe proteins of the ribonuclease‐A (RNase‐A) family are monomeric, with the exception of bovine‐seminal ribonuclease (BS‐RNase). BS‐RNase is formed by swapping the N‐terminal helices across the two monomeric units. A molecular‐dynamics (MD) study has been performed on the protein for a simulation time of 5.5 ns to understand the factors ...
Chakrabarti, Kalyan S, Sanjeev, BS, Vishveshwara, Saraswathi   +2 more
openaire   +4 more sources

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities.

PLoS ONE, 2012
Bovine seminal (BS) RNase, the unique natively dimeric member of the RNase super-family, represents a special case not only for its additional biological actions but also for the singular features of 3D domain swapping.
Giovanni Gotte, Alexander Mahmoud Helmy, Carmine Ercole, Roberta Spadaccini, Douglas V Laurents, Massimo Donadelli, Delia Picone   +6 more
doaj   +1 more source