Results 71 to 80 of about 23,361 (277)
Rational Design of Heterodimeric Protein using Domain Swapping for Myoglobin [PDF]
, 2014 Protein design is a useful method to create novel artificial proteins. A rational approach to design a heterodimeric protein using domain swapping for horse myoglobin (Mb) was developed. As confirmed by X-ray crystallographic analysis, a heterodimeric Mb
Hirota, Shun +12 more
core +1 more source
Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Scientific Reports, 2017 Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold.
Appu K. Singh +2 more
doaj +1 more source
Inverse Design of Amorphous Materials With Targeted Properties
Advanced Materials, EarlyView.AMDEN is a diffusion model framework for the inverse design of amorphous materials with targeted properties. By incorporating Hamiltonian Monte Carlo refinement into the denoising process, the framework overcomes the challenge of generating thermally relaxed disordered structures.
Jonas A. Finkler +4 more
wiley +1 more source
Protein Domain-Swapping Can Be a Consequence of Functional Residues
, 2016 Monomer topology has been implicated in domain-swapping, a potential first step on the route to disease-causing protein aggregation. Despite having the same topology (β1-α1-β2-β3-β4-β5), the cysteine protease inhibitor stefin-B domain swaps more readily ...
Nahren Manuel Mascarenhas (2428174) +1 more
core +1 more source
Scientific Reports, 2018 CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex.
Gundeep Kaur +5 more
doaj +1 more source
Biological Activities of Secretory RNases: Focus on Their Oligomerization to Design Antitumor Drugs
Frontiers in Immunology, 2019 Ribonucleases (RNases) are a large number of enzymes gathered into different bacterial or eukaryotic superfamilies. Bovine pancreatic RNase A, bovine seminal BS-RNase, human pancreatic RNase 1, angiogenin (RNase 5), and amphibian onconase belong to the ...
Giovanni Gotte, Marta Menegazzi
doaj +1 more source
BS‐RNase tetramers: An example of domain‐swapped oligomers [PDF]
FEBS Letters, 1996 In the ribonuclease superfamily, dimericity is a unique feature of bovine seminal RNase (BS‐RNase). In about two‐thirds of native BS‐RNase molecules, the two subunits interchange their N‐terminal tails, thus generating domain‐swapped dimers (MxM), which mostly responsible for enzyme biological activities and allostericity.
S. Adinolfi +3 more
openaire +3 more sources
Measuring the Hall Effect in Hysteretic Materials
Advanced Materials, EarlyView.The authors highlight common pitfalls in measuring the Hall effect: in hysteretic magnets, improper data processing can create signals that look exotic but are not real. This Perspective explains the origin of these artifacts and presents practical measurement strategies that help researchers identify reliable Hall responses in complex magnetic ...
Jaime M. Moya +6 more
wiley +1 more source
The 25 kDa HCN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity
Toxins, 2020 The extraordinarily potent clostridial neurotoxins (CNTs) comprise tetanus neurotoxin (TeNT) and the seven established botulinum neurotoxin serotypes (BoNT/A-G).
Julian Deppe +3 more
doaj +1 more source
Double‐Transition‐Metal MXenes: Multimetallic 2D Platforms for Next‐Generation Biomedicine
Advanced Materials, EarlyView.The present work explores recent progress in double‐transition‐metal MXenes and focuses on their potential as multifunctional biomedical nanoplatforms whose tunable optical, electronic, mechanical, and surface properties enable imaging, theranostics, antimicrobial activity, biosensing, tissue engineering, and drug delivery.
Parsa Namakiaraghi +2 more
wiley +1 more source