Results 81 to 90 of about 22,091 (247)

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Enhanced Antifungal Activity of Engineered Proteins via Swapping between Thioredoxin H2 and H3

Applied Sciences, 2019
Thioredoxins (Trxs) are proteins that act as antioxidants by facilitating the reduction of other proteins and are highly conserved in all organisms. Plant H-type Trx isoforms have different structures and perform multiple functions. Previous studies have
Jin-Young Kim, Yong Hun Chi, Il Ryong Kim, Heabin Kim, Ji Hyun Jung, Seong-Cheol Park, Mi-Kyeong Jang, Sang Yeol Lee, Jung Ro Lee   +8 more
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Energetic differences between non-domain-swapped and domain-swapped chain connectivities in the K2P potassium channel TRAAK

RSC Advances, 2018
In the available crystallographic structures of K2P channels, the cap is present as non-domain-swapped (NDS) and domain-swapped (DS) chain conformations.
Carlos Navarro-Retamal, Julio Caballero
openaire   +3 more sources

Enhanced Ionic Conductivity at the Solid Electrolyte Interphase of Oxygen‐Doped Li6PS5Cl

Advanced Science, EarlyView.
Machine‐learned molecular dynamics and machine‐learning‐based phase identification reveal the kinetically formed SEI at buried Li | Li6PS5Cl interfaces. The SEI is dominated by Li2S‐based anion‐substituted phases, while oxygen doping enhances SEI ionic conductivity.
Sojeong Yang, Sungwoo Kang, Atefeh Yadegarifard, Hyun‐Jae Lee, Nongnuch Artrith, Jung‐Hoon Lee, Byungju Lee   +6 more
wiley   +1 more source

Cation Diffusion‐Mediated Displaced Reaction‐Transformation in Green Steelmaking

Advanced Science, EarlyView.
The removal of O lattice atoms by environmental H2 at the surface of Fe3O4 results in Fe enrichment, driving the inward diffusion of Fe cations into the bulk. Through hopping between unoccupied and initially occupied sites, cation diffusion triggers a spatially displaced reaction‐transformation and drives subsequent dynamic phase transformations and ...
Guangyi Guo, Paul Paciok, Baptiste Bienvenu, Longqi Bai, Barak Ratzker, Marc Heggen, Xuyang Zhou, Dierk Raabe   +7 more
wiley   +1 more source

Bio‐Inspired Bidirectional Winding Origami With Programmable Modular Reconfigurability and Scalability

Advanced Science, EarlyView.
A bio‐inspired bidirectional‐winding origami platform enables scalable and programmable deployable structures. Double axial folding inspired by earwig hindwings and Flasher‐based hybridization create modular multilayer architectures with diverse attainable winding angles under fixed boundary conditions.
Wenyao Zhang, Chunlong Wang, Mingli Liu, Chuang Shi, Hongwei Guo, Rongqiang Liu   +5 more
wiley   +1 more source

The potential of EV battery-swapping in developing countries: China’s use case as a baseline for sub-saharan Africa

Transportation Research Interdisciplinary Perspectives
The global automotive sector is undergoing a profound transformation, driven by the imperative to adopt electric vehicles (EVs) and mitigate carbon emissions.
Daniel Simwaba, Abubaker Qutieshat
doaj   +1 more source

A highly stable laccase obtained by swapping the second cupredoxin domain

Scientific Reports, 2018
The robustness of a high-redox potential laccase has been enhanced by swapping its second cupredoxin domain with that from another fungal laccase, which introduced a pool of neutral mutations in the protein sequence without affecting enzyme functionality.
Isabel Pardo, David Rodríguez-Escribano, Pablo Aza, Felipe de Salas, Angel T. Martínez, Susana Camarero   +5 more
doaj   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source