Results 101 to 110 of about 1,858,101 (277)

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

Energetic differences between non-domain-swapped and domain-swapped chain connectivities in the K2P potassium channel TRAAK

RSC Advances, 2018
In the available crystallographic structures of K2P channels, the cap is present as non-domain-swapped (NDS) and domain-swapped (DS) chain conformations.
Carlos Navarro-Retamal, Julio Caballero
openaire   +3 more sources

Domain swapping, fragment complementation, and self-assembly in engineered chimeric proteins. [PDF]

, 2014
Domain swapping is a form of protein oligomerization in which two or more identical proteins reciprocally exchange parts of their tertiary structure. The structure of the domain swapped proteins is identical to the structure formed by the monomer except
Craft, Matthew
core  

Micelle-Catalyzed Domain Swapping in the GlpG Rhomboid Protease Cytoplasmic Domain

, 2016
Three-dimensional domain swapping is a mode of self-interaction that can give rise to altered functional states and has been identified as the trigger event in some protein deposition diseases, yet rates of interconversion between oligomeric states are ...
Allison R. Sherratt (478883), Houman Ghasriani (1746598), Alexander C. Y. Foo (1746601), Natalie K. Goto (1746604), Tabussom Qureshi (1746592), Jason K. C. Kwok (1746595)   +5 more
core   +1 more source

RSFace: subject agnostic face swapping with expression high fidelity

, 2023
Face swapping has shown remarkable progress with the flourishing development of deep learning. In particular, the emergence of subject agnostic methods has broadened the range of applications of face swapping.
Fang, Xianjin, Yang, Gaoming, Zhang, Ji, Wang, Tao   +3 more
core   +1 more source

Hierarchical Physical‐Cyber Encryption via Metasurface‐Encoded Holographic Keys

Advanced Science, EarlyView.
ABSTRACT Physical‐layer encryption based on metasurfaces has emerged as a promising alternative to conventional algorithmic cryptography by embedding security into physical processes. However, most existing metasurface‐based encryption schemes operate within single‐stage or static frameworks, where correct physical illumination directly reveals the ...
Zhen Liu, Changhong Dai, Wei Zhu, Ruisheng Yang, Bohan Zhang, Lei Zhang, Bobo Du, Shengxiang Wang, Guangwei Hu   +8 more
wiley   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

, 2008
Udgivelsesdato: 2008-Oct-24The crystal structure of the first immunoglobulin (Ig1) domain of neural cell adhesion molecule 2 (NCAM2/OCAM/RNCAM) is presented at a resolution of 2.7 A.
Kulahin, Nikolaj, Kristensen, Ole, Poulsen, Jens-Christian N, Rasmussen, Kim Krighaar, Gajhede, Michael, Kastrup, Jette S, Sigurskjold, Bent W, Bock, Elisabeth, Walmod, Peter S, Berezin, Vladimir   +9 more
core   +1 more source

N–O Dual Functional Group Transposition via Energy Transfer Photocatalysis

Advanced Science, EarlyView.
N–O dual functional group transposition (dFGT) enabled by the photocatalytic energy transfer (EnT) has been developed. This methodology is applicable to both activated and unactivated alkyl derivatives for dFGT, and it also successfully extended to N–N dFGT, demonstrating its general applicability.
Lei Bao, Xueyu Wang, Yang Zhou, Beibei Zhan, Xiaheng Zhang   +4 more
wiley   +1 more source

The potential of EV battery-swapping in developing countries: China’s use case as a baseline for sub-saharan Africa

Transportation Research Interdisciplinary Perspectives
The global automotive sector is undergoing a profound transformation, driven by the imperative to adopt electric vehicles (EVs) and mitigate carbon emissions.
Daniel Simwaba, Abubaker Qutieshat
doaj   +1 more source