Domain swapping and amyloid fibril conformation [PDF]
Prion, 2012 For several different proteins an apparent correlation has been observed between the propensity for dimerization by domain-swapping and the ability to aggregate into amyloid-like fibrils.
Van Der Wel, PCA
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Domain swapping in allosteric modulation of DNA specificity.
PLoS Biology, 2010 SgrAI is a type IIF restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-modulation of cleavage activity and sequence specificity.
Chad K Park +7 more
doaj +3 more sources
3D domain swapping: As domains continue to swap [PDF]
Protein Science, 2002 Abstract Three‐dimensional (3D) domain swapping creates a bond between two or more protein molecules as they exchange their identical domains. Since the term '3D domain swapping' was first used to describe the dimeric structure of diphtheria toxin, the database of domain‐swapped proteins has greatly expanded. Analyses of the now about
Yanshun, Liu, David, Eisenberg
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Domain Swapping and Retroviral Assembly [PDF]
Molecular Cell, 2005 The structure of a mammalian SCAN domain has been recently reported. The molecule is a structural homolog of the HIV-1 capsid protein and forms a domain-swapped dimer in solution. The authors propose a similar domain-swapping event facilitates HIV-1 assembly, providing a new model for protein-protein interactions underlying viral particle formation.
Kingston, Richard L., Vogt, Volker M.
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Topological Determinants of Protein Domain Swapping [PDF]
Structure, 2006 Protein domain swapping has been repeatedly observed in a variety of proteins and is believed to result from destabilization due to mutations or changes in environment. Based on results from our studies and others, we propose that structures of the domain-swapped proteins are mainly determined by their native topologies. We performed molecular dynamics
Ding, Feng +3 more
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Frontiers in Microbiology, 2021 As the incidence of antibiotic-resistant bacteria has become increased, phage endolysins are believed as one of the promising alternatives to antibiotics.
Bokyung Son +7 more
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Dramatic structural changes resulting from the loss of a crucial hydrogen bond in the hinge region involved in C-terminal helix swapping in SurE: a survival protein from Salmonella typhimurium. [PDF]
PLoS ONE, 2013 Domain swapping is an interesting feature of some oligomeric proteins in which each protomer of the oligomer provides an identical surface for exclusive interaction with a segment or domain belonging to another protomer.
Yamuna Kalyani Mathiharan +3 more
doaj +1 more source
Unraveling the Functional Significance of Unstructured Regions in G Protein-Coupled Receptors
Biomolecules, 2023 Unstructured regions in functional proteins have gained attention in recent years due to advancements in informatics tools and biophysical methods.
Roberto Maggio +5 more
doaj +1 more source
Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants [PDF]
PeerJ, 2016 Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and for being able to form the domain-swapped dimers.
Olga V. Stepanenko +5 more
doaj +2 more sources
REC protein family expansion by the emergence of a new signaling pathway
mBio, 2023 This report presents multi-genome evidence that REC protein family expansion occurs when the emergence of new pathways gives rise to functional discordance.
Megan E. Garber +9 more
doaj +1 more source