Results 1 to 10 of about 28,065 (271)

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice

Molecular Brain, 2022
The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the impact of donepezil on tau pathology is unclear.
Hee-Jeong Choi, Jin-Hee Park, Yoo Joo Jeong, Jeong-Woo Hwang, Soojung Lee, Heeyong Lee, Eunyoung Seol, Ik-whi Kim, Byung-Yoon Cha, Jinsoo Seo, Minho Moon, Hyang-Sook Hoe   +11 more
doaj   +2 more sources

Efficacy of Ginkgo biloba as an adjunct to donepezil in amyloid PET-positive Alzheimer’s patients [PDF]

Frontiers in Neurology
BackgroundGinkgo biloba is widely used in some regions as an adjunct therapy for Alzheimer’s disease (AD). Its potential mechanisms include antioxidative and anti-amyloid properties, yet clinical evidence remains mixed.ObjectiveWe investigated whether ...
YoungSoon Yang, Min-Seong Koo, Yong Tae Kwak   +2 more
doaj   +2 more sources

Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking [PDF]

Pharmaceutics
Background/Objectives: Although donepezil, a reversible acetylcholinesterase inhibitor, has been in use since 1996, its metabolic characteristics remain poorly characterized.
Eun-Ji Park, Eui-Hyeon Kim, Ki-Young Kim, Ji-Hyeon Jeon, Im-Sook Song, So-Young Park, Kwang-Hyeon Liu   +6 more
doaj   +2 more sources

Impact of Plasma Donepezil Concentration on Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease

Dementia and Geriatric Cognitive Disorders Extra, 2021
Background/Aims: The behavioral and psychological symptoms of dementia (BPSD) detract from the quality of life of not only dementia patients but also their family members and caregivers.
Yoshiyuki Kagawa, Yoshiaki Yamamoto, Ayami Ueno, Kengo Inomata, Mayu Tezuka, Takashi Osawa, Yasuharu Yazawa, Toshio Maeda, Tomokazu Obi   +8 more
doaj   +1 more source

Cognitive Enhancer Donepezil Attenuates Heroin-Seeking Behavior Induced by Cues in Rats

Journal of Integrative Neuroscience, 2023
Purpose: Opioid use disorder is a significant global problem. Chronic heroin use is associated with impairment of cognitive function and conscious control ability.
Disen Mei, Fangmin Wang, Bo Yuan, Miaojun Lai, Yiying Zhou, Wei Cui, Huifen Liu, Wenhua Zhou   +7 more
doaj   +1 more source

Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease

Journal of Pharmacological Sciences, 2015
The therapeutic response rates of patients to donepezil vary from 20% to 60%, one of the reasons is their genetic differences in donepezil-metabolizing enzymes, which directly influence liver metabolism. However, the mechanism of donepezil metabolism and
Jin Lu, Lili Wan, Yuan Zhong, Qi Yu, Yonglong Han, Pengguo Chen, Beiyun Wang, Wei Li, Ya Miao, Cheng Guo   +9 more
doaj   +1 more source

Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model

Biomolecules, 2020
Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals.
Faez Saleh Al-Hamed, Ola M. Maria, Jeff Phan, Ahmed Al Subaie, Qiman Gao, Alaa Mansour, Lina Abu Nada, Imane Boukhatem, Osama A. Elkashty, Simon D. Tran, Marie Lordkipanidzé, Zahi Badran, Faleh Tamimi   +12 more
doaj   +1 more source

Donepezil-associated survival benefits among Alzheimer’s disease patients are retained but not enhanced during COVID-19 infections

Therapeutic Advances in Infectious Disease, 2023
Background and Aim: Donepezil is a front-line treatment for Alzheimer’s disease. Donepezil treatment is associated with decreased risk of all-cause mortality. Specific protection is observed in pneumonia and cardiovascular disease.
Elizabeth A. Edmiston, Taissa A. Bej, Brigid Wilson, Robin L. P. Jump, Joy A. Phillips   +4 more
doaj   +1 more source

The effect of electroacupuncture combined with donepezil on cognitive function in Alzheimer’s disease patients: study protocol for a randomized controlled trial

Trials, 2017
Background Alzheimer’s disease is a progressive neurodegenerative disease. Although some of the current treatments offer some symptomatic relief, this disease cannot be cured at present.
Weina Peng, Jing Zhou, Min Xu, Qing Feng, Lulu Bin, Zhishun Liu   +5 more
doaj   +1 more source

Donepezil improves vascular function in a mouse model of Alzheimer’s disease

Pharmacology Research & Perspectives, 2021
Cardiovascular complications in Alzheimer's disease (AD) patients can occur years to decades prior to the onset of clinical symptoms of the disease. Donepezil represents the most effective drug in the treatment of AD.
Carolina Pellegrini, Vanessa D’Antongiovanni, Matteo Fornai, Emiliano Duranti, Filippo Baldacci, Nunzia Bernardini, Stefano Taddei, Agostino Virdis, Corrado Blandizzi, Stefano Masi, Luca Antonioli   +10 more
doaj   +1 more source