Results 1 to 10 of about 33,626 (230)

Switching from Oral Cholinesterase Inhibitors to a Transdermal Donepezil Patch Attenuated Gastrointestinal Symptoms and Allowed Treatment Continuation in Three Patients with Alzheimer’s Disease in Clinical Settings [PDF]

Brain Sciences
Background: Cholinesterase inhibitors (ChEIs) are commonly prescribed for the treatment of Alzheimer’s disease (AD) and achieve long-term benefits for cognition and survival in real-world settings.
Yumiko Motoi, Nobuo Sanjo
doaj   +2 more sources

Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys

Biological Psychiatry Global Open Science, 2023
Background: Donepezil exerts pro-cognitive effects by nonselectively enhancing acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro-cognitive effects of attentional control and cognitive flexibility are the prefrontal ...
Seyed A. Hassani, Sofia Lendor, Adam Neumann, Kanchan Sinha Roy, Kianoush Banaie Boroujeni, Kari L. Hoffman, Janusz Pawliszyn, Thilo Womelsdorf   +7 more
doaj   +1 more source

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice

Molecular Brain, 2022
The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the impact of donepezil on tau pathology is unclear.
Hee-Jeong Choi, Jin-Hee Park, Yoo Joo Jeong, Jeong-Woo Hwang, Soojung Lee, Heeyong Lee, Eunyoung Seol, Ik-whi Kim, Byung-Yoon Cha, Jinsoo Seo, Minho Moon, Hyang-Sook Hoe   +11 more
doaj   +1 more source

Impact of Plasma Donepezil Concentration on Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease

Dementia and Geriatric Cognitive Disorders Extra, 2021
Background/Aims: The behavioral and psychological symptoms of dementia (BPSD) detract from the quality of life of not only dementia patients but also their family members and caregivers.
Yoshiyuki Kagawa, Yoshiaki Yamamoto, Ayami Ueno, Kengo Inomata, Mayu Tezuka, Takashi Osawa, Yasuharu Yazawa, Toshio Maeda, Tomokazu Obi   +8 more
doaj   +1 more source

Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease

Journal of the Formosan Medical Association, 2022
Background/purpose: Donepezil was approved for the treatment of Alzheimer's disease (AD) but causes variable therapeutic responses. Thus, identifying specific genetic polymorphisms, which can predict a therapeutic response to donepezil, would enable a ...
Ping-Song Chou, Ling-Chun Huang, Tzyh-Chyuan Hour, Chen-Wen Yen, Yuan-Han Yang   +4 more
doaj   +1 more source

Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice

Journal of Pharmacological Sciences, 2022
Donepezil, an acetylcholinesterase inhibitor, is associated with gastrointestinal symptoms, such as nausea, vomiting, and anorexia, which may affect adherence to continuous therapy.
Kouichi Yamamoto, Yuhki Sato, Keisuke Hagihara, Kyosuke Kirikihira, Akito Jotaki, Ayana Michihara, Yumi Miyake   +6 more
doaj   +1 more source

Nootropics use in the workplace. Psychiatric and ethical aftermath towards the new frontier of bioengineering [PDF]

, 2020
OBJECTIVE: The authors have sought to expound upon and shed a light on the rise of nootropics, which have gradually taken on a more and more relevant role in workplaces and academic settings.
Bersani, G, Ciallella, C, Del Rio, A, Marinelli, E, Rinaldi, Raffaella, Zaami, S   +5 more
core   +1 more source

Cognitive Enhancer Donepezil Attenuates Heroin-Seeking Behavior Induced by Cues in Rats

Journal of Integrative Neuroscience, 2023
Purpose: Opioid use disorder is a significant global problem. Chronic heroin use is associated with impairment of cognitive function and conscious control ability.
Disen Mei, Fangmin Wang, Bo Yuan, Miaojun Lai, Yiying Zhou, Wei Cui, Huifen Liu, Wenhua Zhou   +7 more
doaj   +1 more source

Donepezil-associated survival benefits among Alzheimer’s disease patients are retained but not enhanced during COVID-19 infections

Therapeutic Advances in Infectious Disease, 2023
Background and Aim: Donepezil is a front-line treatment for Alzheimer’s disease. Donepezil treatment is associated with decreased risk of all-cause mortality. Specific protection is observed in pneumonia and cardiovascular disease.
Elizabeth A. Edmiston, Taissa A. Bej, Brigid Wilson, Robin L. P. Jump, Joy A. Phillips   +4 more
doaj   +1 more source

Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease

Journal of Pharmacological Sciences, 2015
The therapeutic response rates of patients to donepezil vary from 20% to 60%, one of the reasons is their genetic differences in donepezil-metabolizing enzymes, which directly influence liver metabolism. However, the mechanism of donepezil metabolism and
Jin Lu, Lili Wan, Yuan Zhong, Qi Yu, Yonglong Han, Pengguo Chen, Beiyun Wang, Wei Li, Ya Miao, Cheng Guo   +9 more
doaj   +1 more source