Results 1 to 10 of about 27,715 (238)
Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
Molecular Brain, 2022 The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the impact of donepezil on tau pathology is unclear.
Hee-Jeong Choi +11 more
doaj +2 more sources
Efficacy of Ginkgo biloba as an adjunct to donepezil in amyloid PET-positive Alzheimer’s patients [PDF]
Frontiers in NeurologyBackgroundGinkgo biloba is widely used in some regions as an adjunct therapy for Alzheimer’s disease (AD). Its potential mechanisms include antioxidative and anti-amyloid properties, yet clinical evidence remains mixed.ObjectiveWe investigated whether ...
YoungSoon Yang +2 more
doaj +2 more sources
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment [PDF]
New England Journal of Medicine, 2005 BACKGROUND Mild cognitive impairment is a transitional state between the cognitive changes of normal aging and early Alzheimer's disease. METHODS In a double-blind study, we evaluated subjects with the amnestic subtype of mild cognitive impairment ...
Ronald Petersen +13 more
openalex +2 more sources
Donepezil for dementia due to Alzheimer's disease [PDF]
Cochrane Database of Systematic Reviews, 2003 Alzheimer's disease is the most common cause of dementia and is a primary degenerative disease of the brain of unknown cause. Onset is usually late in life with increasing impairment of memory, developing gradually into a global impairment of cognition, orientation, linguistic ability and judgement.
J Birks, Richard Harvey
+13 more sources
Frontiers in Neuroscience, 2020 Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the ...
Benjamin Vidal +9 more
doaj +2 more sources
Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking [PDF]
PharmaceuticsBackground/Objectives: Although donepezil, a reversible acetylcholinesterase inhibitor, has been in use since 1996, its metabolic characteristics remain poorly characterized.
Eun-Ji Park +6 more
doaj +2 more sources
International Journal of Molecular Sciences, 2021 The acetylcholinesterase inhibitors donepezil and rivastigmine have been used as therapeutic drugs for Alzheimer’s disease (AD), but their effects on LPS- and Aβ-induced neuroinflammatory responses and the underlying molecular pathways have not been ...
Jieun Kim +8 more
semanticscholar +1 more source
Journal of Healthcare Engineering, 2022 Objective To explore the effect of resveratrol (RES) combined with donepezil hydrochloride on inflammatory factor level and cognitive function level of patients with Alzheimer's disease (AD). Methods A total of 90 AD patients treated in our hospital from
Xincui Fang +3 more
semanticscholar +1 more source
Age and Ageing, 2006 An 85-year-old lady with a 4-year history of Alzheimer's dementia was started on a dose of 5 mg of Donepezil. Improvements were noted in her overall mental state with an associated reduction in the level of carer stress but with mild and transient subjective gastrointestinal complaints. Therefore, the dose was cautiously increased to 10 mg.
Ananth Puranik, Chetan Bangra Kuloor
openaire +3 more sources
Dementia and Geriatric Cognitive Disorders Extra, 2021 Background/Aims: The behavioral and psychological symptoms of dementia (BPSD) detract from the quality of life of not only dementia patients but also their family members and caregivers.
Yoshiyuki Kagawa +8 more
doaj +1 more source