Results 121 to 130 of about 43,876 (313)
Differential dementia detection from multimodal brain images in a real‐world dataset
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION Artificial intelligence (AI) models have been applied to differential dementia detection tasks in brain images from curated, high‐quality benchmark databases, but not real‐world data in hospitals. METHODS We describe a deep learning model specially trained for disease detection in heterogeneous clinical images from electronic ...
Matthew Leming, Hyungsoon Im
wiley +1 more source
A case of Diogenes Syndrome [PDF]
, 2013 Diogenes Syndrome is a syndrome of extreme selfneglect, domestic squalor, excessive hoarding, social withdrawal and refusal of all help and lack of concern regarding one’s personal residential situation. A case report of an 83 year old lady with mild
Ferry, Peter
core
Representation learning of drug and disease terms for drug repositioning
, 2017 Drug repositioning (DR) refers to identification of novel indications for the approved drugs. The requirement of huge investment of time as well as money and risk of failure in clinical trials have led to surge in interest in drug repositioning.
Anand, Ashish, Manchanda, Sahil
core +1 more source
Is the relationship among outcome variables shown in randomized trials? [PDF]
, 2015 BACKGROUND: Randomized controlled trials (RCTs) often have more than one primary outcome and frequently have secondary and harm outcomes. Comparison of outcomes between study arms is the primary focus of RCTs, but there are times when the relation ...
Altman, Douglas +4 more
core +1 more source
Basic and Clinical Neuroscience, 2019 Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region ...
Azade Eskandary +3 more
doaj
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019 Introduction Donepezil is a widely used cholinesterase inhibitor in the management of Alzheimer's disease. Despite large‐scaled evidence for its efficacy, elevated peripheral ACh levels often lead to side effects and are dose limiting.
Anne Catrien Baakman +6 more
doaj +1 more source
Clinical Interventions in Aging, 2018 Donepezil, an acetylcholinesterase inhibitor (AChEI), has been widely used to treat Alzheimer’s disease (AD) in China. However, there are few studies focusing on the efficacy and safety of donepezil in Chinese patients.
N. Zhang, M. Gordon
semanticscholar +1 more source
A Short Story Changed How I Care for Persons Living With Dementia
Journal of the American Geriatrics Society, EarlyView.
Jason Karlawish
wiley +1 more source
Brain and Behavior, Volume 15, Issue 7, July 2025.Conceptual schematic illustrating the trial design and mechanisms. Electroacupuncture (EA) targets cervical acupoints (GB20/Gongxue) to improve cerebral blood flow and neural connectivity. HOT (herbal olfactory therapy) delivers Acorus Tatarinowii volatile oil via inhalation to penetrate the blood‐brain barrier, reduce neuroinflammation, and enhance ...
Ying Dandan +4 more
wiley +1 more source
Auditory training changes temporal lobe connectivity in 'Wernicke's aphasia': a randomised trial [PDF]
, 2017 INTRODUCTION: Aphasia is one of the most disabling sequelae after stroke, occurring in 25%-40% of stroke survivors. However, there remains a lack of good evidence for the efficacy or mechanisms of speech comprehension rehabilitation.
Crinion, J +5 more
core +3 more sources