Results 121 to 130 of about 33,626 (230)

Rapamycin Reduces Amyloid‐β Plaques and Improves Behavioral Performance in a Sex‐Dependent Manner in Mouse Models of Amyloidosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Rapamycin treatment reduced cerebral Aβ plaque burden, alleviated neuritic dystrophy, suppressed glial hyperactivation, and increased plaque‐associated microglial recruitment in amyloidosis mouse models, resulting in improved memory performance. Mechanistically, rapamycin enhanced microglial lysosomal degradation, facilitated lipid droplet clearance in
Shihui Guo, Weishan Fu, Yating Wang, Qi Liu, Jiaxin Li, Kai Guo, Hongsheng Zhang   +6 more
wiley   +1 more source

Effect of concomitant use of yokukansan on steady‐state blood concentrations of donepezil and risperidone in real‐world clinical practice

Neuropsychopharmacology Reports
Aim Yokukansan is one of the most frequently used herbal medicines that can improve the behavioral and psychological symptoms of dementia. In this exploratory study, we investigated whether yokukansan affects the steady‐state blood concentrations of ...
Junji Saruwatari, Tetsuya Kaneko, Tsukasa Murata, Haruka Narise, Sawa Kugimoto, Eri Nishimura, Natsuki Tetsuka, Misaki Ando, Momo Oi, Masako Ota, Nayumi Hamada, Keiichiro Kaneda, Shiro Furusho, Masakatsu Sakamoto, Ayami Kajiwara‐Morita, Kazutaka Oda, Kentaro Oniki, Keishi Ueda, Hirofumi Jono, Norio Yasui‐Furukori   +19 more
doaj   +1 more source

Integrated Anatomical, Chemical, Biological and Computational Studies Approach of Myrcia sylvatica (G. Mey) DC. A Multifaceted Insight Into a Promising Amazonian Species

Flavour and Fragrance Journal, Volume 41, Issue 2, Page 270-293, March 2026.
This study presents an integrated anatomical, chemical, biological, and computational analysis of Myrcia sylvatica, revealing key bioactive compounds with antioxidant and toxicological potential, and identifying spathulenol and globulol as promising acetylcholinesterase inhibitors with favourable pharmacokinetic properties. ABSTRACT Myrcia sylvatica (G.
Eliza de Jesus Barros dos Santos, Zelina Ataíde Correia, Ely Simone Cajueiro Gurgel, Leonardo Souza da Costa, Mabrouk Horchani, Hayet Edziri, Ravendra Kumar, Anderson de Santana Botelho, Karyme do Socorro de Souza Vilhena, Eloisa Helena de Aguiar Andrade, Mozaniel Santana de Oliveira   +10 more
wiley   +1 more source

Structural Characterization and Anti‐Alzheimer's Disease Effect of Polysaccharides From Stellariae Radix

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Stellaria dichotoma polysaccharides (SDP) was extracted from Stellariae Radix and comprehensively characterized using UV–Vis, FT‐IR, NMR spectroscopy and HPLC analysis. The results revealed that SDP is composed of galactose, glucose, arabinose, galacturonic acid, mannose, and rhamnose.
Meixia Sun, Jiaxin He, Huan Song, Zhi Ma, Xilian Zhang, Juan Li, Yao Yao   +6 more
wiley   +1 more source

Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking

Pharmaceutics
Background/Objectives: Although donepezil, a reversible acetylcholinesterase inhibitor, has been in use since 1996, its metabolic characteristics remain poorly characterized.
Eun-Ji Park, Eui-Hyeon Kim, Ki-Young Kim, Ji-Hyeon Jeon, Im-Sook Song, So-Young Park, Kwang-Hyeon Liu   +6 more
doaj   +1 more source

Astragalus Polysaccharides Can Effectively Alleviate Cognitive Impairment in Mice With Alzheimer's Disease by Regulating the Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This schematic diagram illustrates that Astragalus polysaccharides improve cognitive dysfunction in 3xTg AD mice by regulating the gut‐brain axis. APS ameliorates gut microbiota and enhances intestinal barrier function, thereby reducing systemic and central inflammation, inhibiting microglial overactivation, and alleviating Aβ deposition and Tau ...
Xilian Wang, Xinyun Ge, Xin Di, Zhiyan Zou, Dan Lei, Zihao Wang, Jiaqiang Hou, Yan Yang, Wanxue Zhang, Yuan Yin, Xinnuo Lei, Yu Long, Xuemin Jian, Xiaoan Li   +13 more
wiley   +1 more source

Comprehensive Exploration of Three Pistachio Varieties: Antidiabetic, Anticholinergic, Antioxidant Properties, Phytochemical Profile by LC–MS/MS, and Molecular Docking

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Phytochemical profiles, biological activities, and molecular docking studies of pistachio varieties. ABSTRACT Pistachios (Pistacia vera L.) are a significant food that is added to many foods and also consumed as a snack. The kernel part is consumed very much.
Ebubekir İzol, Büşra Beltekin, Münire Turhan, Şirvan Karakoç, Adem Necip, Mustafa Abdullah Yılmaz, Gökhan Zengin, Oğuz Çakır   +7 more
wiley   +1 more source

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers

Drug Design, Development and Therapy, 2015
Yo Han Kim,1 Hee Youn Choi,1 Hyeong-Seok Lim,1 Shi Hyang Lee,1 Hae Sun Jeon,1 Donghyun Hong,2 Seong Su Kim,2 Young Kweon Choi,2 Kyun-Seop Bae1 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical ...
Kim YH, Choi HY, Lim HS, Lee SH, Jeon HS, Hong D, Kim SS, Choi YK, Bae KS   +8 more
doaj  

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, Volume 12, Issue 1, Page 3-37, Spring 2026.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Pyrazoline Derivatives: Synthesis, In Silico, Enzyme Kinetics Studies and Biological Activity against Cholinesterase, Lipoxygenase, and α‐Amylase

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Nucleophilic cyclization of the α, β‐unsaturated carbonyl framework of the prepared (E)‐4‐(3‐bromo‐4‐hydroxy‐5‐methoxyphenyl)but‐3‐en‐2‐one with various hydrazine derivatives to afford their corresponding pyrazolines has been achieved. The enzyme assays conducted showed significant α‐amylase inhibitory activity for 4b with IC50 value of 2.7 µM.
Redolf S. Segodi, E. N. Agbo, Leoma B. Mofeli, K. W. Poopedi, O. O. Oderinlo, W. Nxumalo   +5 more
wiley   +1 more source