Results 131 to 140 of about 21,434 (231)

Donepezil for severe Alzheimer's disease.

, 2006
We feel that the paper by Bengt Winblad and colleagues1 on the use of donepezil for patients with severe Alzheimer's disease omits two essential points which should be considered when interpreting this study.
Fullwood, Nigel J., Martin, Frank, Allsop, David, Moore, Susan   +3 more
core  

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1687-1691, June 2026.
ABSTRACT Background Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged ≥ 80 years remains limited. This study aimed to evaluate the long‐term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older.
Ophir Lavon, Wafaa Hamodi, Sameer Kassem
wiley   +1 more source

Association of Combined Lifestyle Behaviors With Healthspan in Older Adults

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1614-1625, June 2026.
In 11,287 older adults from the ASPirin in Reducing Events in the Elderly (ASPREE) cohort, healthy lifestyle behaviors were defined as Mediterranean diet, regular physical activity, moderate alcohol intake, and non‐smoking. Participants with three or more favorable behaviors had a 40% lower hazard of death, dementia, or persistent physical disability ...
Catherine Robb, Prudence R. Carr, Jocasta Ball, Galina Polekhina, Daniel Clayton‐Chubb, Elena S. George, Jessica Fitzpatrick, Lawrence J. Beilin, Anne B. Newman, Alice Owen, Suzanne G. Orchard, Cammie Tran, Joanne Ryan, John J. McNeil   +13 more
wiley   +1 more source

The Association Between Hospital Harms and 1‐Year Mortality Following a Hip Fracture in Ontario, Canada: A Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1658-1667, June 2026.
ABSTRACT Background Hip fractures are a significant public health concern, associated with substantial morbidity and mortality. Mortality is the most serious consequence of hip fractures, with a 1‐year rate ranging from 14% to 36%. Hospital harms are also more prevalent among older adults with hip fractures, further increasing their risk of mortality ...
Anum Ali, Arrani Senthinathan, Laleh Rashidian, Yu Qing Bai, Walter P. Wodchis, Susan E. Bronskill, Chantal Backman, Kednapa Thavorn, Kerry Kuluski, Sara J. T. Guilcher   +9 more
wiley   +1 more source

Sensory Impairment and Risk of Elder Mistreatment in Community‐Dwelling Older Adults

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1668-1675, June 2026.
Adjusted probabilities of elder mistreatment based on none, one, or multi‐sensory impairments (vision, hearing, and/or olfaction). Results suggest an association between multisensory loss and elder mistreatment risk. ABSTRACT Background Emotional and financial mistreatment among older adults is often under‐recognized among clinicians. Exploring whether
Mara W Rosenberg, Evelyn Li, Wei‐Lin Xue, Elizabeth Eckstrom, Melissa Howe, Alexander K. Smith, Ashwin A. Kotwal   +6 more
wiley   +1 more source

Donepezil: Pharmacoeconomic Implications of Therapy

_ Donepezil is a specific acetylcholinesterase inhibitor that can improve symptoms in patients with mild-to-moderate Alzheimer's disease; cognitive function is maintained above baseline levels for up to 1 year and normal decline of cognitive function is ...
Rachel H. Foster, Greg L. Plosker
core  

Designing Consent Processes for Research With Older Adults Who May Lack Decisional Capacity: A Guide for Investigators

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1715-1721, June 2026.
ABSTRACT Securing a participant's voluntary, informed consent is widely acknowledged as a requirement of ethical research. Yet, challenges can arise, particularly when a researcher seeks to enroll older adults who may lack the capacity to consent to research participation due to cognitive impairment.
Emily A. Largent, Stephanie R. Morain, Jason Karlawish   +2 more
wiley   +1 more source

The effect of canagliflozin on hippocampal dendrite morphology in a model of Alzheimer's disease induced by intracerebroventricular injection of streptozotocin. [PDF]

Brain Struct Funct
Yazi S, Ozen B, Buldu B, Yalcin E, Karakose O, Cakmak O, Somunkiran S, Yananli HR, Sehirli US, Kirazli O.   +9 more
europepmc   +1 more source

Donepezil for dementia due to Alzheimer's disease

, 2006
Donepezil for dementia due to Alzheimer's ...
Richard Harvey (13090974), J Birks (13591477)   +1 more
core  

Entropy estimation in acetylcholinesterase-donepezil interaction through topological indices: a graph theoretical perspective. [PDF]

Front Chem
Gayathri KB, Roy S, Jyothish K.
europepmc   +1 more source