Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect
Journal of Pharmacological Sciences, 2019 Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models.
Takehiro Kawashiri +4 more
doaj +1 more source
Donepezil-induced psychosis: a cautionary report of a rare adverse reaction
European Psychiatry, 2023 Introduction Donepezil is an acetylcholinesterase inhibitor approved by the Food and Drug Administration for the treatment of dementia in Alzheimer’s disease. While it is not curative for Alzheimer’s disease, donepezil has been shown to improve symptoms
K. R. Hutchings +3 more
doaj +1 more source
The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial [PDF]
, 2017 BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a group of psychological reactions, psychiatric symptoms, and behaviors commonly found in Alzheimer's disease (AD).
Amenta, Francesco +6 more
core +1 more source
(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications
Angewandte Chemie, EarlyView.In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh +5 more
wiley +2 more sources
Adherence and Tolerability of Alzheimer's Disease Medications: A Pragmatic Randomized Trial [PDF]
, 2017 BACKGROUND/OBJECTIVES: Post-marketing comparative trials describe medication use patterns in diverse, real-world populations. Our objective was to determine if differences in rates of adherence and tolerability exist among new users to ...
Boustani, Malaz A. +8 more
core +1 more source
Journal of Pharmacological Sciences, 2003 Donepezil, an acetylcholinesterase (AChE) inhibitor, has not been evaluated for its binding characteristics using a radioactive tracer, although its inhibitory action on AChE has been studied.
Yoshihito Funaki +7 more
doaj +1 more source
Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada. [PDF]
, 2015 This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia.
Abagyan, Ruben +4 more
core +3 more sources
Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
Journal of Neuroinflammation, 2017 Background Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related
Yoshinori Haraguchi +8 more
doaj +1 more source
Neurology and Therapy, 2023 Introduction This multicentre, randomised, open-label, and prospective study aimed to evaluate the effectiveness of memantine (memantine solution) on speech function in patients with moderate to severe Alzheimer’s disease (AD) who were already on ...
Hee-Jin Kim +11 more
doaj +1 more source
Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis. [PDF]
PLoS ONE, 2017 This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive ...
Ruey Chen +6 more
doaj +1 more source