Results 21 to 30 of about 28,065 (271)

Donepezil for dementia due to Alzheimer's disease [PDF]

Cochrane Database of Systematic Reviews, 2003
Alzheimer's disease is the most common cause of dementia and is a primary degenerative disease of the brain of unknown cause. Onset is usually late in life with increasing impairment of memory, developing gradually into a global impairment of cognition, orientation, linguistic ability and judgement.
JS Birks, Richard Harvey
  +13 more sources

Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature

Journal of Chemical Information and Modeling, 2020
Donepezil is a second generation acetylcholinesterase (AChE) inhibitor for treatment of Alzheimer's disease (AD). AChE is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate ...
MonicaA. Silva, A. S. Kiametis, W. Treptow   +2 more
semanticscholar   +1 more source

Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice

Molecules, 2021
The pharmacokinetic (PK) change in a drug by co-administered herbal products can alter the efficacy and toxicity. In the circumstances that herb–drug combinations have been increasingly attempted to alleviate Alzheimer’s disease (AD), the PK evaluation ...
Mingoo Bae, Seung Yon Han, Eun-Sun Kim, Byung Hoon You, Young-Mi Kim, Jungsook Cho, Young-Won Chin, Young Hee Choi   +7 more
doaj   +1 more source

Meta-Analysis of Randomized Controlled Trials on the Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer’s Disease

Frontiers in Neuroscience, 2019
To study the impact of donepezil, rivastigmine, galantamine, and memantine on cognitive, functional, behavioral, global changes and adverse effects in patients with mild, moderate and severe Alzheimer’s disease (AD), we screened the literature published ...
Dandan Li, Ya-hong Zhang, Wei Zhang, Pu Zhao   +3 more
semanticscholar   +1 more source

Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia

Journal of Neuroinflammation, 2017
Background Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related
Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro A. Kato, Akira Monji   +8 more
doaj   +1 more source

A Multicentre, Randomised, Open-Label, Prospective Study to Estimate the Add-On Effects Of Memantine as Ebixa® Oral Pump (Solution) on Language in Patients with Moderate to Severe Alzheimer’s Disease Already Receiving Donepezil (ROMEO-AD)

Neurology and Therapy, 2023
Introduction This multicentre, randomised, open-label, and prospective study aimed to evaluate the effectiveness of memantine (memantine solution) on speech function in patients with moderate to severe Alzheimer’s disease (AD) who were already on ...
Hee-Jin Kim, YongSoo Shim, Hyun Jeong Han, Byeong C. Kim, Kee Hyung Park, So Young Moon, Seong Hye Choi, Dong Won Yang, Bora Yoon, Eun-Joo Kim, Jee Hyang Jeong, Seol-Heui Han   +11 more
doaj   +1 more source

Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys

Biological Psychiatry Global Open Science, 2023
Background: Donepezil exerts pro-cognitive effects by nonselectively enhancing acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro-cognitive effects of attentional control and cognitive flexibility are the prefrontal ...
Seyed A. Hassani, Sofia Lendor, Adam Neumann, Kanchan Sinha Roy, Kianoush Banaie Boroujeni, Kari L. Hoffman, Janusz Pawliszyn, Thilo Womelsdorf   +7 more
doaj  

Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis. [PDF]

PLoS ONE, 2017
This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive ...
Ruey Chen, Pi-Tuan Chan, Hsin Chu, Yu-Cih Lin, Pi-Chen Chang, Chien-Yu Chen, Kuei-Ru Chou   +6 more
doaj   +1 more source

Donepezil-induced psychosis: a cautionary report of a rare adverse reaction

European Psychiatry, 2023
Introduction Donepezil is an acetylcholinesterase inhibitor approved by the Food and Drug Administration for the treatment of dementia in Alzheimer’s disease. While it is not curative for Alzheimer’s disease, donepezil has been shown to improve symptoms
K. R. Hutchings, B. K. Hutchings, B. Ratnakaran, A. S. Kablinger   +3 more
doaj   +1 more source

Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation

Acta Pharmacologica Sinica, 2020
Vascular dementia (VD) is the second most common dementia disease after Alzheimer’s diseases (AD) in the world. Donepezil is used to treat mild to moderate AD, and it has been shown to treat cognitive impairment and memory deficits caused by VD. However,
Wen-xuan Jian, Zhao Zhang, Jia-hong Zhan, Shi-Feng Chu, Ye Peng, Ming Zhao, Qi Wang, N. Chen   +7 more
semanticscholar   +1 more source