Results 31 to 40 of about 28,065 (271)

Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice

Journal of Pharmacological Sciences, 2022
Donepezil, an acetylcholinesterase inhibitor, is associated with gastrointestinal symptoms, such as nausea, vomiting, and anorexia, which may affect adherence to continuous therapy.
Kouichi Yamamoto, Yuhki Sato, Keisuke Hagihara, Kyosuke Kirikihira, Akito Jotaki, Ayana Michihara, Yumi Miyake   +6 more
doaj  

Donepezil in the Treatment of Narcolepsy [PDF]

Journal of Clinical Sleep Medicine, 2006
Chronic excessive sleepiness impairs the daily life of patients suffering from narcolepsy. Antidepressants that enhance synaptic levels of noradrenaline and serotonin have been reported as having some therapeutic efficacy. For that reason, acetylcholinesterase inhibitors, which elevate acetylcholine levels, may have a protective function with respect ...
openaire   +3 more sources

Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Molecular Medicine, 2023
Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as ...
Thawatchai Khuanjing, Chayodom Maneechote, Benjamin Ongnok, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn   +8 more
doaj   +1 more source

Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease

Scientific Reports, 2019
This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits.
Sitah Al Harthi, S. Alavi, M. Radwan, Mona Mohamed El Khatib, I. Alsarra   +4 more
semanticscholar   +1 more source

Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease

Journal of the Formosan Medical Association, 2022
Background/purpose: Donepezil was approved for the treatment of Alzheimer's disease (AD) but causes variable therapeutic responses. Thus, identifying specific genetic polymorphisms, which can predict a therapeutic response to donepezil, would enable a ...
Ping-Song Chou, Ling-Chun Huang, Tzyh-Chyuan Hour, Chen-Wen Yen, Yuan-Han Yang   +4 more
doaj  

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

Molecules, 2021
Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet.
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova   +14 more
doaj   +1 more source

Clinical Recommendations for the Use of Donepezil 23 mg in Moderate-to-Severe Alzheimer's Disease in the Asia-Pacific Region

Dementia and Geriatric Cognitive Disorders Extra, 2016
Background: The ‘Asia-Pacific Expert Panel (APEX) for donepezil 23 mg' met in November 2015 to review evidence for the recently approved high dose of donepezil and to provide recommendations to help physicians in Asia make informed clinical decisions ...
Marwan Sabbagh, SeolHeui Han, SangYun Kim, Hae-Ri Na, Jae-Hong Lee, Nagaendran Kandiah, Kammant Phanthumchinda, Chuthamanee Suthisisang, Vorapun Senanarong, Ming-Chyi Pai, Diatri Narilastri, Ajit M. Sowani, Encarnita Ampil, Amitabh Dash   +13 more
doaj   +1 more source

A review of clinical treatment considerations of donepezil in severe Alzheimer's disease

CNS Neuroscience & Therapeutics, 2018
Alzheimer's disease (AD) is a neurodegenerative disorder that affects over 45 million people worldwide. Patients with severe AD require help with daily activities and show severe memory impairment. Currently, donepezil is one of two drugs approved by FDA
A. Adlimoghaddam, Melanie Neuendorff, Banibrata Roy, B. Albensi   +3 more
semanticscholar   +1 more source

Convulsions induced by donepezil [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1999
Donepezil, a centrally acting acetylcholinesterase inhibitor, has been recently introduced for the symptomatic relief of cognitive impairment in patients with mild to moderate Alzheimer’s disease. Several adverse events thought to be related to donepezil have been reported so far, the most common ones being gastrointestinal disturbances due to ...
N Zurak, T Babic
openaire   +2 more sources

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source