Results 31 to 40 of about 43,876 (313)
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]
, 2017 Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat +6 more
core +3 more sources
Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
Journal of Neuroinflammation, 2017 Background Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related
Yoshinori Haraguchi +8 more
doaj +1 more source
Frontiers in Neuroscience, 2019 To study the impact of donepezil, rivastigmine, galantamine, and memantine on cognitive, functional, behavioral, global changes and adverse effects in patients with mild, moderate and severe Alzheimer’s disease (AD), we screened the literature published ...
Dandan Li +3 more
semanticscholar +1 more source
Neurology and Therapy, 2023 Introduction This multicentre, randomised, open-label, and prospective study aimed to evaluate the effectiveness of memantine (memantine solution) on speech function in patients with moderate to severe Alzheimer’s disease (AD) who were already on ...
Hee-Jin Kim +11 more
doaj +1 more source
Intellectual autonomy, epistemic dependence and cognitive enhancement [PDF]
, 2017 Intellectual autonomy has long been identified as an epistemic virtue, one that has been championed influentially by (among others) Kant, Hume and Emerson.
Carter, J. Adam
core +1 more source
Biological Psychiatry Global Open Science, 2023 Background: Donepezil exerts pro-cognitive effects by nonselectively enhancing acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro-cognitive effects of attentional control and cognitive flexibility are the prefrontal ...
Seyed A. Hassani +7 more
doaj
Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis. [PDF]
PLoS ONE, 2017 This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive ...
Ruey Chen +6 more
doaj +1 more source
Donepezil-induced psychosis: a cautionary report of a rare adverse reaction
European Psychiatry, 2023 Introduction Donepezil is an acetylcholinesterase inhibitor approved by the Food and Drug Administration for the treatment of dementia in Alzheimer’s disease. While it is not curative for Alzheimer’s disease, donepezil has been shown to improve symptoms
K. R. Hutchings +3 more
doaj +1 more source
New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation [PDF]
, 2016 A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE).
Chiarotto, Isabella +9 more
core +1 more source
N‐Insertion of Diazonium Salts Into Ketone Derivatives
Angewandte Chemie, EarlyView.Diazonium salts insert into ketones and their silyl enol ethers through a sequence of α‐azenylation and ring expansion via an N‐iminoaziridinium species. Coupled with an efficient N‐N bond cleavage, this protocol offers a mild alternative to Beckmann rearrangements and a powerful tool for skeletal editing of ketones.
Mohammed Anif Pasha +3 more
wiley +2 more sources