Results 31 to 40 of about 33,626 (230)

Potential implications of practice effects in Alzheimer's disease prevention trials. [PDF]

, 2017
IntroductionPractice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treatment, can minimize effects of ...
Ard, M Colin, Bondi, Mark W, Edland, Steven D, Galasko, Douglas R, Jacobs, Diane M, Salmon, David P   +5 more
core   +1 more source

Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Molecular Medicine, 2023
Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as ...
Thawatchai Khuanjing, Chayodom Maneechote, Benjamin Ongnok, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn   +8 more
doaj   +1 more source

The association of changes of sleep architecture related to donepezil: A systematic review and meta-analysis

Journal of the Formosan Medical Association, 2022
Background: Donepezil had been recognized to have impact on sleep quality in demented patients. However, there was insufficient evidences about the actual effect of donepezil in the sleep architectures.
Cheng-Fang Hsieh, Ping-Tao Tseng, Tien-Yu Chen, Pao-Yen Lin, Yen-Wen Chen, Bo-Lin Ho, Chung-Yao Hsu, Ching-Kuan Liu   +7 more
doaj   +1 more source

Bayesian value-of-infomation analysis: an application to a policy model of Alzheimer's disease [PDF]

, 2001
A framework is presented that distinguishes the conceptually separate decisions of which treatment strategy is optimal from the question of whether more information is required to inform this choice in the future.
Araki, S., Claxton, K., Neumann, P.J., Weinstein, M.C.   +3 more
core   +1 more source

Efficacy of Ginkgo biloba as an adjunct to donepezil in amyloid PET-positive Alzheimer’s patients

Frontiers in Neurology
BackgroundGinkgo biloba is widely used in some regions as an adjunct therapy for Alzheimer’s disease (AD). Its potential mechanisms include antioxidative and anti-amyloid properties, yet clinical evidence remains mixed.ObjectiveWe investigated whether ...
YoungSoon Yang, Min-Seong Koo, Yong Tae Kwak   +2 more
doaj   +1 more source

Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy [PDF]

, 2013
Introduction: Memantine and cholinesterase inhibitors potentially offer additional benefits in Alzheimer's disease (AD) when used together. This study assessed the efficacy and safety of combination treatment with memantine added to stable donepezil in ...
Atri, Alireza, Lemming, Ole, Molinuevo, José L, Pulte, Irena, Wilkinson, David, Wirth, Yvonne   +5 more
core   +1 more source

Evaluating Response to High-Dose 13.3 mg/24 h Rivastigmine Patch in Patients with Severe Alzheimer's Disease [PDF]

, 2015
AIMS: To identify factors predicting improvement/stabilization on the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) and investigate whether early treatment responses can predict long-term outcomes, during a ...
Farlow, Martin R., Islam, M. Zahur, Meng, Xiangyi, Sadowsky, Carl H., Velting, Drew M.   +4 more
core   +1 more source

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

Molecules, 2021
Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet.
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova   +14 more
doaj   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Effects of non-pharmacological or pharmacological interventions on cognition and brain plasticity of aging individuals. [PDF]

, 2014
Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of ...
Cesinaro, Stefano, Esposito, Roberto, Frazzini, Valerio, Pieramico, Valentina, Sensi, Stefano L   +4 more
core   +2 more sources