Results 71 to 80 of about 28,065 (271)

Evaluation of the Binding Characteristics of [5-11C-methoxy]Donepezil in the Rat Brain for In Vivo Visualization of Acetylcholinesterase

Journal of Pharmacological Sciences, 2003
Donepezil, an acetylcholinesterase (AChE) inhibitor, has not been evaluated for its binding characteristics using a radioactive tracer, although its inhibitory action on AChE has been studied.
Yoshihito Funaki, Motohisa Kato, Ren Iwata, Eiko Sakurai, Eiichi Sakurai, Manabu Tashiro, Tatsuo Ido, Kazuhiko Yanai   +7 more
doaj  

The association of changes of sleep architecture related to donepezil: A systematic review and meta-analysis

Journal of the Formosan Medical Association, 2022
Background: Donepezil had been recognized to have impact on sleep quality in demented patients. However, there was insufficient evidences about the actual effect of donepezil in the sleep architectures.
Cheng-Fang Hsieh, Ping-Tao Tseng, Tien-Yu Chen, Pao-Yen Lin, Yen-Wen Chen, Bo-Lin Ho, Chung-Yao Hsu, Ching-Kuan Liu   +7 more
doaj  

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy.
Irene Pachón-Angona, B. Refouvelet, Rudolf Andrýs, H. Martin, V. Luzet, I. Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, M. Oset-Gasque, J. Marco-Contelles, K. Musílek, L. Ismaili   +11 more
semanticscholar   +1 more source

Implementation of Lecanemab for Alzheimer's Disease Within the Veterans Health Administration: Facilitators and Barriers

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Several amyloid targeting therapies have been approved for Alzheimer's disease (AD), including lecanemab (Leqembi). However, real‐world implementation of these drugs has uncovered significant challenges. Methods We conducted a national cross‐sectional survey of healthcare professionals from multiple disciplines participating in the ...
Alison J. O'Donnell, Alexandra T. Fortunato, Brittany L. Spitznogle, Naveen M. Reddy, Shaye A. Kerper, Steven M. Handler   +5 more
wiley   +1 more source

Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients

Clinical Interventions in Aging, 2018
Nan Zhang,1,2 Marc L Gordon3,4 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 2Department of Neurology and Neurosurgery, Tianjin Medical University ...
Zhang N, Gordon ML
doaj  

Impact of the Tailored Activity Program (TAP) on Depressive Symptoms Among White and Black Dementia Caregivers

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Depressive symptoms are common in caregivers of people with dementia, with most interventions targeting their emotional/cognitive stance. Unknown is whether targeting people with dementia's quality of life can improve caregiver mood.
Laura N. Gitlin, David L. Roth, Katherine Marx   +2 more
wiley   +1 more source

Accelerated Intermittent Theta Burst Stimulation Combined with Balance Training Improves Balance in an Individual with Corticobasal Syndrome

Movement Disorders Clinical Practice, EarlyView.
Karishma R. Ramdeo, Stevie D. Foglia, Malaikah Ahmad, Nafia Al‐Mutawaly, Justin Lee, Robert Chen, Aimee J. Nelson   +6 more
wiley   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Clinical Observation on Basal Ganglia Aphasia after Stroke Treated by Donepezil

康复学报, 2015
Objective:To evaluate the curative effect of donepezil on basal ganglia aphasia after stroke.Methods:A total of 37 patients with basal ganglia aphasia after stroke were randomly assigned to donepezil group (n=19) and control group (n=18).
Xi CHENG, Jinghui LAI, Zhifeng WANG, Yanling GAO, Xiaofeng CHEN, Ling LIN   +5 more
doaj  

The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention

Frontiers in Aging Neuroscience
IntroductionDonepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD).
Ting Yang, Fuquan Wei, Yufei Guo, Mengxiao Zhu, Hongtao Hou, Zhongwei Guo, Xiaozheng Liu, Xiaozheng Liu   +7 more
doaj   +1 more source