Results 71 to 80 of about 43,876 (313)

Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells

Journal of Pharmacological Sciences, 2007
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer’s disease. To elucidate whether donepezil causes neuronal differentiation, we examined its effect on nerve growth factor (NGF)-induced neurite ...
Toru Oda, Toshiaki Kume, Hiroshi Katsuki, Tetsuhiro Niidome, Hachiro Sugimoto, Akinori Akaike   +5 more
doaj  

Neuroprotective effects of donepezil against Aβ25-35-induced neurotoxicity

European Journal of Medical Research, 2022
Purpose The purpose of this study was to investigate the neuroprotective effect of donepezil against β-amyloid25-35 (Aβ25-35)-induced neurotoxicity and the possible mechanism. Methods PC12 cells were conventionally cultured. Serial concentrations of Aβ25-
Bu-Lang Gao, Ning-Ning Che, Xue Li, Chun-Feng Ren   +3 more
doaj   +1 more source

QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine

Therapeutic Advances in Drug Safety, 2020
Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and rivastigmine are used to treat Alzheimer’s disease (AD). This study aimed to evaluate evidence from the case report literature for an association between these ...
Katie Malone, J. Hancox
semanticscholar   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi, Byung Hak Jin, Do Hoon Keum, Kyoung Hoon Mo, Min Soo Park, Juhwan Lee, Sungjin Park, Choon Ok Kim   +7 more
wiley   +1 more source

Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy [PDF]

, 2013
Introduction: Memantine and cholinesterase inhibitors potentially offer additional benefits in Alzheimer's disease (AD) when used together. This study assessed the efficacy and safety of combination treatment with memantine added to stable donepezil in ...
Atri, Alireza, Lemming, Ole, Molinuevo, José L, Pulte, Irena, Wilkinson, David, Wirth, Yvonne   +5 more
core   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

NICE 2011 recommendations on the management of Alzheimer’s disease by acetylcholinesterase inhibitors and memantine [PDF]

, 2011
The National Institute of Clinical Excellence (NICE) has lately overturned its decision to restrict the use of acetycholinesterase inhibitors and memantine in patients diagnosed with Alzheimer’s disease (AD).
Scerri, Charles
core  

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, EarlyView.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

Određivanje donepezil hidroklorida u humanoj plazmi i ljekovitim oblicima pomoću HPLC s detekcijom fluorescencije [PDF]

, 2011
A sensitive, isocratic reversed-phase high performance liquid chromatographic method involving fluorescence detection was developed for the determination of donepezil hydrochloride in tablets and in human plasma.
B. Sultry, G. Khaledi, G. Shabir, Gamal Mostafa, H. Ermer, H. Pappa, H. Sugimoto, I. Lott, J. Hiten, J. Miller, K. Nakashima, M. Radwan, Mohamed Kassem, Mohammed Abonassif, Mohammed Hefnawy, N. Furukori, P. Jeong, S. Kafkala, V. Meyer, Y. Hsin-Hua   +19 more
core   +2 more sources