Results 71 to 80 of about 8,474,282 (288)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Pretransplant IgG subclasses of donor-specific human leukocyte antigen antibodies and development of antibody-mediated rejection

, 2011
The subclass of IgG antibodies contributes to their capability to activate complement. It is currently unknown whether the pretransplant IgG subclass composition allows distinguishing harmful from presumably irrelevant donor-specific human leukocyte ...
Schaub, Stefan, Gideon Hönger, Patrizia Amico, Stefan Schaub, Hönger, Gideon, Amico, Patrizia, Marie-Luise Arnold, Spriewald, Bernd M., Helmut Hopfer, Arnold, Marie-Luise, Bernd M. Spriewald, Hopfer, Helmut, Hopfer H, Arnold ML, Amico P, Spriewald BM, Schaub S, Hönger G   +17 more
core   +1 more source

Machine learning enhanced immunologic risk assessments for solid organ transplantation

Scientific Reports
The purpose of this study was to enhance the prediction of solid-organ recipient and donor crossmatch compatibility by applying machine learning (ML). Prediction of crossmatch compatibility is complex and requires an understanding of the recipient and ...
Eric T. Weimer, Katherine A. Newhall
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Role of donor-specific antibodies in immunological assessment for kidney transplant: A report of ten cases in a cost-limited set-up

Indian Journal of Transplantation, 2020
Sensitized patients, who constitute a considerable proportion of kidney-transplant recipients, often have poor allograft outcomes. Only cell-based complement-dependent cytotoxicity (CDC) assays are typically used to quantify donor-specific antibodies ...
Joyita Bharati, Deepesh Benjamin Kenwar, Sarabpreet Singh, Ritambhra Nada, Harbir Singh Kohli, Manish Rathi, Ashish Sharma, Ranjana Walker Minz, Raja Ramachandran   +8 more
doaj   +1 more source

The impact of HLA donor-specific antibodies on engraftment and the evolving desensitization strategies.

, 2022
The majority of contemporary allogeneic hematopoietic stem cell transplantation (HCT) procedures utilize partially HLA-mismatched stem cell grafts. Donor-specific anti-HLA antibodies (DSA) are associated with primary graft failure independent of the ...
Gergis, Usama, MD, MBA, File, Brittany, Huang, Yanping, Peedin, Alexis   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Utility of Routine Post Kidney Transplant Anti-HLA Antibody Screening

Kidney International Reports
Introduction: De novo donor-specific antibody (dnDSA) is a strong biomarker associated with the development of antibody-mediated rejection (AMR) and graft loss after kidney transplantation.
Sofiane Salhi, Nicolas Congy-Jolivet, Anne-Laure Hebral, Laure Esposito, Guillaume Vieu, Jean Milhès, Nassim Kamar, Arnaud Del Bello   +7 more
doaj   +1 more source

Desensitization with plasma exchange in a patient with human leukocyte antigen donor-specific antibodies before T-cell-replete haploidentical hematopoietic stem cell transplantation

Journal of Applied Hematology, 2019
The presence of human leukocyte antigen (HLA) donor-specific antibodies (DSAs) increases the risk of graft failure in T-cell-replete haploidentical hematopoietic stem cell transplantation (haploidentical-HSCT). We report a case of a 20-year-old male with
Rasika Dhawan Setia, Mitu Dogra, Divya Doval, Sanjeev Kumar Sharma, Dharma Choudhary, Anil Handoo   +5 more
doaj   +1 more source