Results 61 to 70 of about 8,474,282 (288)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Eosinophilic infiltration as the initial trace of acute mixed cellular and antibody mediated rejection in a heart transplant patient with concomitant immense epitope-associated HLA-antibody production: a case report

Frontiers in Immunology, 2023
Acute mixed cellular and antibody-mediated rejection (MR) has an estimated prevalence of 7.8%. However, knowledge of MR immune pathogenesis in cardiac graft rejection remains sparse.
Marie Skougaard, Steen Bærentzen, Hans Eiskjær, Pernille Koefoed-Nielsen   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Development of non-donor-specific HLA antibodies after kidney transplantation : frequency and clinical implications

, 2009
Patients undergoing renal transplantation frequently have non-donor-specific HLA antibodies (NDSA). There could be NDSA (e.g. a negative crossmatch in a sensitized patient), or could be donor-specific HLA antibodies (DSA) (e.g., antibody-incompatible ...
Zehnder, Daniel, Briggs, D., Higgins, Rob   +2 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Successful lung transplantation in the presence of pre-existing donor-specific cytotoxic HLA Class II antibodies

, 2012
Pre-existing HLA antibodies are a well-established causal factor for rejection and graft dysfunction after solid-organ transplantation. In lung transplant recipients, the significance of HLA antibodies has not been fully established.
Verschuuren, Erik A., Erasmus, Michiel E., Timens, Wim; id_orcid, Jongsma, Theo, Bouwman, Ilby, van den Berg, Aad P., Lambeck, Annechien J. A., Hepkema, Bouke G., Lems, Simon P. M., van der Bij, Wim, Verschuuren, Erik A.; id_orcid, Roozendaal, Caroline, Bungener, Laura B., Timens, Wim   +13 more
core   +1 more source

Absence of Donor-Specific Anti-HLA Antibodies After ABO-Incompatible Heart Transplantation in Infancy: Altered Immunity or Age? [PDF]

, 2010
Specific B-cell tolerance toward donor blood group antigens develops in infants after ABO-incompatible heart transplantation, whereas their immune response toward protein antigens such as HLA has not been investigated.
Nuebel, J., West, Lori J., Meyer, S. R., Urschel, S., Platt, Jeffrey L., Campbell, P. M., Derkatz, K., Birnbaum, J., Coe, J. Y., Kauke, T., Netz, H., Larsen, I. M., Tinckam, K.   +12 more
core   +2 more sources

Teclistamab desensitization of donor-specific antibodies in aplastic anemia

Haematologica
Not available.
Paulina García Maldonado, Valentine Jiménez Antolinez, Julia Colunga-Pedraza, Ginna Romero Jacobo, Oscar González-Llano, David Gómez-Almaguer, Andrés Gómez-De León   +6 more
doaj   +1 more source

Redefining Cardiac Antibody-Mediated Rejection With Donor-Specific Antibodies and Graft Dysfunction. [PDF]

Circ Heart Fail
BACKGROUND: Heart transplant recipients with donor-specific antibodies (DSAs) have an increased risk for antibody-mediated rejection. However, many patients with graft dysfunction and DSA do not have evidence of antibody-mediated rejection by endomyocardial biopsy (EMB).
Goldberg JF, Tian X, Bon A, Xu Y, Gerhard E, Brower R, Jang MK, Kong H, Andargie TE, Park W, Najjar SS, Tchoukina I, Shah KB, Hsu S, Rodrigo ME, Marboe C, Berry GJ, Valantine HA, Shah P, Agbor-Enoh S.   +19 more
europepmc   +3 more sources