Results 41 to 50 of about 8,474,282 (288)

Beyond Donor-Specific Antibodies: The Unseen Role of Non-Donor-Specific Anti-human Leukocyte Antigen (HLA) Antibodies in Rejection. [PDF]

Cureus
Antibody-mediated rejection (ABMR) is conventionally defined by the presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA), characteristic microvascular injury on allograft biopsy, and evidence of complement activation, most commonly reflected by C4d deposition. We report the case of a 46-year-old woman who underwent a fully HLA-
Kashiv P, Balwani M, Pasari AS, Kute V.
europepmc   +4 more sources

Kidney paired donation in the presence of donor-specific antibodies [PDF]

Kidney International, 2013
Incompatible donor/recipient pairs with broadly sensitized recipients have difficulty finding a crossmatch-compatible match, despite a large kidney paired donation pool. One approach to this problem is to combine kidney paired donation with lower-risk crossmatch-incompatible transplantation with intravenous immunoglobulin.
Jeremy M, Blumberg, Hans A, Gritsch, Elaine F, Reed, J M, Cecka, Gerald S, Lipshutz, Gabriel M, Danovitch, Suzanne, McGuire, David W, Gjertson, Jeffrey L, Veale   +8 more
openaire   +2 more sources

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

Living Donor Kidney Transplantation in Patients With Donor-Specific HLA Antibodies After Desensitization With Immunoadsorption

Frontiers in Medicine, 2021
Due to the current organ shortage, living donor kidney transplantation is increasingly performed across HLA (human leukocyte antigen) or ABO antibody barriers. There is still uncertainty about the risk of antibody-mediated rejection (AMR) episodes, which
Florian Kälble, Caner Süsal, Caner Süsal, Luiza Pego da Silva, Claudius Speer, Louise Benning, Christian Nusshag, Lien Pham, Hien Tran, Matthias Schaier, Claudia Sommerer, Jörg Beimler, Arianeb Mehrabi, Martin Zeier, Christian Morath   +14 more
doaj   +1 more source

The impact of preformed donor‐specific antibodies in living donor liver transplantation according to graft volume

Immunity, Inflammation and Disease, 2022
Introduction The roles of preformed anti‐HLA donor‐specific antibodies (DSAs) in liver transplantation remain controversial. We evaluated the impact of preformed DSAs in living donor liver transplantation.
Ryoichi Goto, Makoto Ito, Norio Kawamura, Masaaki Watanabe, Yoshikazu Ganchiku, Toshiya Kamiyama, Tsuyoshi Shimamura, Akinobu Taketomi   +7 more
doaj   +1 more source

Donor-specific antibodies and organ transplantation: a dangerous mix [PDF]

International Reviews of Immunology, 2019
Scientific and technical advancements provided a deeper insight into the cellular and molecular processes of the host immunity and its clinical significance in various aspects of human health, incl...
Mihai, Oltean, Himanshu, Kumar
openaire   +2 more sources

Pediatric Kidney Transplantation—Can We Do Better? The Promise and Limitations of Epitope/Eplet Matching

Frontiers in Pediatrics, 2022
Kidney transplant is the optimal treatment for end-stage kidney disease as it offers significant survival and quality of life advantages over dialysis.
Olga Charnaya, Daniella Levy Erez, Daniella Levy Erez, Sandra Amaral, Dimitrios S. Monos   +4 more
doaj   +1 more source

Donor-Specific Antibodies in Kidney Transplant Recipients [PDF]

Clinical Journal of the American Society of Nephrology, 2017
Donor-specific antibodies have become an established biomarker predicting antibody-mediated rejection. Antibody-mediated rejection is the leading cause of graft loss after kidney transplant. There are several phenotypes of antibody-mediated rejection along post-transplant course that are determined by the timing and extent of ...
openaire   +2 more sources

Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival [PDF]

In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In
Melchers, Rowena C.A., van der Pant, Karlijn A.M.I., van Duijnhoven, Elly M., Heidt, Sebastiaan, Hack, Cornelis E., Baas, Marije C., Joosten, Irma, Drop, Adriaan C.A.D., Christiaans, Maarten H.L., Sanders, Jan Stephan, Gelens, Mariëlle A.C.J., Kroesen, Bart Jan, van der Meer, Arnold, Wieten, Lotte, Claas, Frans H., Seelen, Marc A.J., Otten, Henny G., Plaisier, Loes, Betjes, Michiel G.H., Roelen, Dave L., Hoitsma, Andries, van Ittersum, Frans J., van Zuilen, Arjan D., van der Weerd, Neelke C., Wisse, Bram W., de Fijter, Johan W., Allebes, Wil A., van der Boog, Paul J.M., Senejohnny, Danial Mohammadi, Lardy, Neubury M., Kamburova, Elena G., Gruijters, Maartje L., Tilanus, Marcel G.J., Bemelman, Frederike J., Verhaar, Marianne C., Voorter, Christina E., Hepkema, Bouke G., ten Berge, Ineke J.M., Swelsen, Wendy, Spierings, Eric, van Reekum, Franka E., Hilbrands, Luuk B., Kardol-Hoefnagel, Tineke, Nurmohamed, Shaikh A., Bungener, Laura B., Roozendaal, Caroline, Nefro Vasculaire Geneeskunde, CTI CFF, Circulatory Health, Regenerative Medicine and Stem Cells, CDL Cluster Speciële Diagnostiek, CTI Otten, MS Nefrologie, Infection & Immunity, CDL Unit SKIM, CTI, Cancer   +56 more
core   +5 more sources

Residual Activatability of Circulating Tfh17 Predicts Humoral Response to Thymodependent Antigens in Patients on Therapeutic Immunosuppression

Frontiers in Immunology, 2019
The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells.
Suzan Dahdal, Suzan Dahdal, Carole Saison, Carole Saison, Martine Valette, Emmanuel Bachy, Emmanuel Bachy, Nicolas Pallet, Nicolas Pallet, Bruno Lina, Bruno Lina, Bruno Lina, Alice Koenig, Alice Koenig, Guillaume Monneret, Thierry Defrance, Emmanuel Morelon, Emmanuel Morelon, Emmanuel Morelon, Olivier Thaunat, Olivier Thaunat, Olivier Thaunat   +21 more
doaj   +1 more source