Results 191 to 200 of about 2,880,162 (249)

Convalescent plasma therapy for COVID-19 - Donor selection strategies and establishment of a plasma bank. [PDF]

New Microbes New Infect
Kajova M, Khawaja T, Levonen I, Pietilä JP, Virtanen J, Pakkanen SH, Välimaa H, Nousiainen A, Hepojoki J, Sironen T, Vierikko A, Ihalainen J, Vapalahti O, Kantele A.   +13 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

New Donor Selection Criteria Result in Optimal Outcomes of Kidneys from Uncontrolled Donation After the Circulatory Determination of Death. [PDF]

Transplant Direct
Campos S, Ballesteros MA, Rodrigo E, López Del Moral C, Campos-Juanatey F, Suberviola B, García-Alcalde L, Amaya A, Domínguez-Gil B, Ruiz-San Millan JC, Miñambres E.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Donor Selection in Living Donors: Prospects and Problems

, 1999
Rizvi, A., Akhtar, Fazal, Naqvi, A., Mazhar, F., Ahmed, R., Jamal, H.   +5 more
core   +1 more source

Novel machine learning technique further clarifies unrelated donor selection to optimize transplantation outcomes. [PDF]

Blood Adv
Spellman SR, Sparapani R, Maiers M, Shaw BE, Laud P, Bupp C, He M, Devine SM, Logan BR.   +8 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An exploratory study of perceptions and utilization of genetic information in the intended parent experience of oocyte donor selection. [PDF]

J Assist Reprod Genet
Kalscheur C, Kashmola-Perez I, Rust L, McCarthy Veach P, Redlinger-Grosse K.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The future of organ transplantation donor selection: opportunities and challenges in the era of precision medicine. [PDF]

Int J Surg
Liu Y, Feng R, Chen J, Yan H, Liu X.
europepmc   +1 more source