Results 101 to 110 of about 101,529 (354)

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

open access: yesAdvanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou   +10 more
wiley   +1 more source

Activation of DREAM (downstream regulatory element antagonistic modulator), a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice.

open access: yesBiological Psychiatry, 2015
BACKGROUND Previous studies have implicated the cyclic adenosine monophosphate/protein kinase A pathway as well as FosB and dynorphin-B expression mediated by dopamine D1 receptor stimulation in the development of 3,4-dihydroxyphenyl-L-alanine (L-DOPA ...
I. Ruiz-DeDiego   +4 more
semanticscholar   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

open access: yesAdvanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li   +7 more
wiley   +1 more source

‐DOPA

open access: yes, 2000
Chronic treatment with L-DOPA induces dyskinesia in patients with Parkinson's disease (PD) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, but is not thought to do so in normal humans or primates.
Pearce, R K B   +7 more
core   +1 more source

RETRACTION: Differential Involvement of Ras‐GRF1 and Ras‐GRF2 in L‐DOPA‐Induced Dyskinesia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
RETRACTION: S. Bido, N. Solari, M. Indrigo, A. D’Antoni, R. Brambilla, M. Morari, and S. Fasano, “Differential Involvement of Ras‐GRF1 and Ras‐GRF2 in L‐DOPA‐Induced Dyskinesia,” Annals of Clinical and Translational Neurology 2, no. 6 (2015): 662–678, https://doi.org/10.1002/acn3.202. The above article, published online on 24 April 2015 in Wiley Online
wiley   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu   +12 more
wiley   +1 more source

Peripheral dopa decarboxylase inhibition on striatal neurone firing and dopa kinetics in the rat [PDF]

open access: yes, 1995
The work described in this thesis attempts to answer experimentally some questions that have arisen in the clinical treatment of Parkinson's Disease. Namely 1) Dose the time course of plasma dopa and its metabolites after systemic administration alone ...
Chang, Wan-Ya
core   +1 more source

5-Hydroxy-tryptophan for the treatment of l-DOPA-induced dyskinesia in the rat Parkinson's disease model

open access: yesNeurobiology of Disease, 2013
The serotonin system has recently emerged as an important player in the appearance of l-DOPA-induced dyskinesia (LID) in experimental models of Parkinson's disease, as it provides an unregulated source of l-DOPA-derived dopamine release in the dopamine ...
Elisabetta Tronci   +6 more
doaj   +1 more source

Models of probabilistic category learning in Parkinson's disease: Strategy use and the effects of L-dopa [PDF]

open access: yes, 2010
Probabilistic category learning (PCL) has become an increasingly popular paradigm to study the brain bases of learning and memory. It has been argued that PCL relies on procedural habit learning, which is impaired in Parkinson's disease (PD). However, as
Lagnado, DA   +4 more
core  

‐DOPA) for forward osmosis

open access: yes, 2020
Uzal, Nigmet/0000-0002-0912-3459To overcome low permeability and fouling problems of membranes used in FO processes, modification is needed to improve the hydrophilicity, permeability and selectivity of membranes.
Saki, Seda   +3 more
core   +1 more source

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