Results 101 to 110 of about 58,036 (310)
A schematic overview of Dopa-proteins and Dopa in mussel adhesion.
, 2014 (A) Schematic cross-section of an adhesive plaque with mussel foot protein distribution. (B) Sequence of Mfp-5 highlighting distribution of Dopa (blue) and charged residues.
J. Herbert Waite (471128) +4 more
core +1 more source
A Mononuclear Scenario for the Copper‐Catalyzed Monooxygenation of Phenolic Substrates
Chemistry – A European Journal, EarlyView.ABSTRACT Whereas a dinuclear pathway applies to the monooxygenation of phenols by the type 3 copper enzyme tyrosinase, a mononuclear pathway has been identified for the same reaction in corresponding small‐molecule systems. DFT calculations of five copper model complexes reveal that the latter mechanism is energetically feasible, identifying all ...
Alexander Koch +3 more
wiley +1 more source
Fluoxetine Improves the Effect of Levodopa on 6-Hydroxy Dopamine-Induced Motor Impairments in Rats [PDF]
Advanced Pharmaceutical Bulletin, 2012 Purpose: Long term L-DOPA therapy in Parkinson’s disease is associated with troublesome motor fluctuations such as L -DOPA Induced dyskinesia and wearing off effect.
Javad Mahmoudi +3 more
doaj
L-DOPA causes mitochondrial dysfunction in vitro: A novel mechanism of L-DOPA toxicity uncovered
, 2019 © 2019 Elsevier Ltd In Parkinson's disease (PD), as in many other neurodegenerative disorders, mitochondrial dysfunction, protein misfolding, and proteotoxic stress underly the disease process.
Djordjevic, SP +4 more
core +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.This work reports one‐pot synthesized novel zwitterionic polydopamine‐silica (ZSiPDA) nanofillers for fabricating PES hybrid ultrafiltration membranes with enhanced hydrophilicity, permeability, and antifouling performance. The optimized membrane achieved over 91% humic acid removal and showed strong potential for municipal wastewater treatment.
Roqaya A. Ismail +5 more
wiley +1 more source
European Journal of Inorganic Chemistry, EarlyView.The herein‐developed tyrosinase model complex enables the transfer of tyrosinase‐like catalytic oxygenation activity into artificial systems. Therefore, it enables the use of molecular oxygen for oxygenation and oxidation of phenolic substrates at room temperature.
Rosalie Dalhoff +3 more
wiley +1 more source
MoleculesThe use of phosphodiesterase inhibitors in the treatment of Parkinson’s disease is currently widely discussed. The study aimed to investigate the impact of acute and chronic treatment with the phosphodiesterase 5 inhibitor, sildenafil, at low and ...
Elżbieta Lorenc-Koci +3 more
doaj +1 more source
L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain
Parkinson's Disease, 2012 Astrocyte endfeet surround brain blood vessels and can play a role in the delivery of therapeutic drugs for Parkinson’s disease. However, there is no previous evidence of the presence of LAT transporter for L-DOPA in brain astrocytes except in culture ...
M. Y. Inyushin +9 more
doaj +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
The Design and Evaluation of an l-Dopa–Lazabemide Prodrug for the Treatment of Parkinson’s Disease
Molecules, 2017 l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and less than 1% of the oral dose is ...
Monique Hoon +3 more
doaj +1 more source