Results 81 to 90 of about 112,750 (306)

O‐Terphenyl‐basierte Familie konjugierter Makrozyklen: Selektive Erkennung von Phenylalanin im Wasser und Interaktion mit Insulin

Angewandte Chemie, EarlyView.
Diese Studie beschreibt die Herstellung und Eigenschaften einer neuen Familie von o‐Terphenyl‐basierten Makrozyklen, TP[n] (n = 2‐8). Der Trimer bindet Phenylalanin in Wasser sehr effizient und ist dabei zehnmal selektiver als bei anderen Aminosäuren und aromatischen Neurotransmittern.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source

Proposing a Parkinson's disease specific tremor scale from the MDS-UPDRS. [PDF]

, 2015
Background: This article proposes an International Parkinson and Movement Disorder Society (MDS)- UPDRS tremor-based scale and describes its measurement properties, with a view to developing an improved scale for assessing tremor in Parkinson’s disease ...
Bain, PG, Deuschl, G, Elble R,, Forjaz, MJ, Haubenberger, D, Martinez Martin, P, Rodriguez-Blazquez, C, Testa, C   +7 more
core   +1 more source

o‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin

Angewandte Chemie International Edition, EarlyView.
This study presents the synthesis and binding properties of a new family of o‐terphenyl‐based macrocycles, TP[n] (n = 2‐8). The trimer variant efficiently binds phenylalanine in water with a 10‐fold selectivity compared to other amino acids and aromatic neurotransmitters.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source

5-Hydroxy-tryptophan for the treatment of l-DOPA-induced dyskinesia in the rat Parkinson's disease model

Neurobiology of Disease, 2013
The serotonin system has recently emerged as an important player in the appearance of l-DOPA-induced dyskinesia (LID) in experimental models of Parkinson's disease, as it provides an unregulated source of l-DOPA-derived dopamine release in the dopamine ...
Elisabetta Tronci, Carlo Lisci, Roberto Stancampiano, Camino Fidalgo, Maria Collu, Paola Devoto, Manolo Carta   +6 more
doaj   +1 more source

The use of a battery of tracking tests in the quantitative evaluation of neurological function [PDF]

A tracking test battery has been applied in a drug trail designed to compare the efficacy of L-DOPA and amantadine to that of L-DOPA and placebo in the treatment of 28 patients with Parkinson's disease.
Albers, J. W., Potvin, A. R., Repa, B. S., Tourtellotte, W. W.   +3 more
core   +1 more source

Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions. [PDF]

, 2010
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with ...
Antonini A, BARONE, PAOLO, BILO, LEONILDA, De Gaspari D, SANTANGELO, Gabriella, Trojano L, VITALE, CARMINE   +6 more
core  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Mussel adhesive protein inspired coatings: a versatile method to fabricate silica films on various surfaces [PDF]

, 2012
A simple and versatile biomimetic strategy for the fabrication of silica films on a variety of substrates including gold, polystyrene and silicon wafers was developed using nanogram amounts per cm 2 of silicatein.
Akhilesh Rai, Bellomo, Belton, Belton, Belton, Belton, Bernecker, Bernmann, Betancor, Brott, Cai, Cai, Carole C. Perry, Carturan, Caruso, Cha, Cha, Coffman, Coradin, Croce, Dalsin, Giordano, Glawe, Grant, Hu, Hylton, Kambhampati, Kent, Kim, Kim, Kleijn, Knecht, Kroger, Kroger, Laugel, Lee, Lee, Lee, Luckarift, Lundgren, Macech, Menzel, Naik, Patwardhan, Patwardhan, Pogula, Rai, Rai, Ruach-Nir, Schmidt, Shimizu, Stein, Sun, Sun, Tahir, Tahir, Tahir, Thompson, Thompson, Tomczak, Underfriend, Waite, Waite, Waite, Waite, Xi, Xu, Yamamoto, Zhou   +68 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Service-based survey of dystonia in Munich [PDF]

, 2002
We performed a service-based epidemiological study of dystonia in Munich, Germany. Due to favourable referral and treatment patterns in the Munich area, we could provide confident data from dystonia patients seeking botulinum toxin treatment.
Ben-Shlomo, Y., Ceballos-Baumann, Andres, Conrad, B., Gasser, T., Kamm, C., Konkiewitz, E. C., Trender-Gerhard, I., Warner, T.   +7 more
core   +1 more source