Results 61 to 70 of about 58,036 (310)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Plasma Dopa and Feeding

Experimental Biology and Medicine, 1989
Dopa is a normal constituent of plasma in man and experimental animals. Dopa concentrations in plasma have been used to reflect the activity of tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of catecholamines. However, it is not known to what extent plasma dopa is affected by feeding, since several foods contain dopa or tyrosine, the ...
B, Banwart, T D, Miller, J D, Jones, G M, Tyce   +3 more
openaire   +2 more sources

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

The Cardiovascular Actions of DOPA Mediated by the Gene Product of ocular albinism 1

Journal of Pharmacological Sciences, 2014
l-3,4-Dihydroxyphenylalanine (DOPA) is the metabolic precursor of dopamine, and the single most effective agent in the treatment of Parkinson’s disease.
Yoshio Goshima, Fumio Nakamura, Daiki Masukawa, Sandy Chen, Motokazu Koga   +4 more
doaj   +1 more source

Mass spectrometry imaging identifies abnormally elevated brain L-DOPA levels and extrastriatal monoaminergic dysregulation in L-DOPA-induced dyskinesia

, 2021
L-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of L-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates.
Crossman, Alan R., Fernagut, Pierre-Olivier,, Fridjonsdottir, Elva,, Vallianatou, Theodosia, Bezard, Erwan, Fernagut, Pierre-Olivier, Schembri, Luke, Bezard, Erwan,, Shariatgorji, Mohammadreza,, Schembri, Luke S, Andrén, Per, Nilsson, Anna,, Crossman, Alan R.,, Odell, Luke, Crossman, Alan, Svenningsson, Per, Andrén, Per E., Odell, Luke R.,, Fridjonsdottir, Elva, Andrén, Per E.,, Shariatgorji, Mohammadreza, Nilsson, Anna, Shariatgorji, Reza, Vallianatou, Theodosia,, Schembri, Luke S,, Svenningsson, Per,, Odell, Luke R.   +26 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

DNA‐mimic for Specific Surface Functionalization of Zr‐MOFs for Bacterial Targeting

Angewandte Chemie, EarlyView.
We introduce phosphotyrosine‐modified PNA as a superior, single‐step post‐synthesis surface coating for PCN‐222. The DNA mimic allows for controlled post‐functionalization with single‐stranded DNA for the attachment of protein moieties for bacterial targeting. ABSTRACT Nanosized metal–organic frameworks (MOFs) are versatile platforms used in biomedical
Anna Scheeder, Jon Ostolaza‐Paraiso, Andrew G. Baker, Juan F. Blandez, Georgina E. Lindop, Simon M. Fairclough, Ljiljana Fruk, Ioanna Mela, David Fairen‐Jimenez, Clemens F. Kaminski   +9 more
wiley   +2 more sources

In situ continuous Dopa supply by responsive artificial enzyme for the treatment of Parkinson’s disease

Nature Communications, 2023
Oral dihydroxyphenylalanine (Dopa) administration to replenish neuronal dopamine remains the most effective treatment for Parkinson’s disease (PD). However, unlike the continuous and steady dopamine signaling in normal neurons, oral Dopa induces dramatic
Xiao Fang, Meng Yuan, Fang Zhao, Aoling Yu, Qianying Lin, Shiqing Li, Huichen Li, Xinyang Wang, Yanbin Yu, Xin Wang, Qitian Lin, Chunhua Lu, Huanghao Yang   +12 more
doaj   +1 more source

Light- or Dark-Colored, L-DOPA-Based Melanins

, 2018
This report is a continuation of previous research on the H2O2-mediated synthesis of melanin-like pigments. We synthesized and characterized L-DOPA-based pigments using air- or H2O2-mediated oxidation.
Margaret M., Whalen, Koen, Vercruysse, Margaret M. Whalen (5450180), Koen Vercruysse (4630618)   +3 more
core   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source