Results 191 to 200 of about 58,036 (310)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Evidence that tyrosine hydroxylase does not have enzymatic activity in neurons of the supraoptic nucleus. [PDF]

Front Endocrinol (Lausanne)
Pronina TS, Troshev DV, Kolacheva AA, Bogdanov VV, Ugrumov MV.   +4 more
europepmc   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Systems engineering of <i>Escherichia coli</i> for high-level hydroxytyrosol production. [PDF]

Synth Syst Biotechnol
Zuo J, Zhang S, Huang W, Liu J, Gao C, Hu GP, Song W, Li X, Wei W, Wu J, Liu L, Liu K, Xu N.   +12 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

A click-crosslinked dopamine-functionalized hydrogel for therapeutic delivery of stem cell-derived extracellular vesicles.

Biomater Sci
Copus JS, Park JH, Atala A, Lee SJ.
europepmc   +1 more source

Wearable sensors for monitoring drug pharmacokinetics in patients with Parkinson's disease. [PDF]

Sci Rep
Guo YJ, Li CC, Huang JA, Singh K, Mellini H, Lin YH, Yu CC, Fang TC, Pi CC, Chen PC, Li CY, Fan SY, Huang WC, Tsai TH, Liao YT, Tai LC.   +15 more
europepmc   +1 more source

Analyses and Comparisons of the Antimicrobial-Cytotoxic Effects and Molecular Docking Study of L-DOPA and L-DOPA Methyl Ester

Yüksek biyouyumluluk, düşük sitotoksisite ve gelişmiş antibakteriyel özelliklere sahip bileşiklerin sentezlenmesinin artanönemi güncel araştırmalarda açıkça görülmektedir.
Balcı, Hüseyin, Aysan, Arzu, Karaca, Tuğçe Deniz, Sert, Yusuf   +3 more
core  

Diagnosis of Growth Hormone Deficiency in Children: Comparative Performance of Arginine Versus Glucagon as the First Stimulation Test

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Growth hormone deficiency (GHD) diagnosis typically requires the performance of two sequential stimulation tests. Glucagon stimulation test (GST) and arginine stimulation test (AST) are widely used. This study aimed to determine the most suitable order of tests.
David Shaki, Daria Shvarts, Eli Hershkovitz, Lior Carmon, Hazan Guy, Bachar Yoav, Alon Haim   +6 more
wiley   +1 more source

Dopaminergic modulation of pancreatic beta-cell insulin secretion and implications for antipsychotic-induced glucose dysregulation: a systematic review and meta-analysis. [PDF]

Neuropsychopharmacology
Al-Hasani W, Cheliotis-James T, Wierzbicki AS, Freyberg Z, Howes O, Pillinger T.   +5 more
europepmc   +1 more source