Results 1 to 10 of about 807,462 (376)

Whole-Brain Confocal Imaging Provides an Accurate Global View of the Nigral Dopamine System [PDF]

Diagnostics
Clinicopathological studies and the effectiveness of dopaminergic replacement therapy establish that dopamine loss is the key pathology causing motor symptoms in Parkinson’s disease. The dopamine neurons that are impaired in Parkinson’s disease reside in
Fu-Ming Zhou
doaj   +2 more sources

Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

Frontiers in Aging Neuroscience, 2019
Background: The dopaminergic system has been associated with the progression of Alzheimer's disease. But previous studies found inconsistent results regarding the relationship between Alzheimer's disease and dopamine when looking at dopamine receptor ...
Xiongfeng Pan, Atipatsa C. Kaminga, Atipatsa C. Kaminga, Shi Wu Wen, Shi Wu Wen, Xinyin Wu, Xinyin Wu, Kwabena Acheampong, Kwabena Acheampong, Aizhong Liu   +9 more
doaj   +2 more sources

AFFNet: An Attention-Based Feature-Fused Network for Surface Defect Segmentation

Applied Sciences, 2023
Recently, deep learning methods have widely been employed for surface defect segmentation in industrial production with remarkable success. Nevertheless, accurate segmentation of various types of defects is still challenging due to their irregular ...
Xiaodong Chen, Chong Fu, Ming Tie, Chiu-Wing Sham, Hongfeng Ma   +4 more
doaj   +1 more source

RGSB-UNet: Hybrid Deep Learning Framework for Tumour Segmentation in Digital Pathology Images

Bioengineering, 2023
Colorectal cancer (CRC) is a prevalent gastrointestinal tumour with high incidence and mortality rates. Early screening for CRC can improve cure rates and reduce mortality.
Tengfei Zhao, Chong Fu, Ming Tie, Chiu-Wing Sham, Hongfeng Ma   +4 more
doaj   +1 more source

Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. [PDF]

PLoS Biology, 2005
Brain dopamine is critically involved in movement control, and its deficiency is the primary cause of motor symptoms in Parkinson disease. Here we report development of an animal model of acute severe dopamine deficiency by using mice lacking the ...
Tatyana D Sotnikova, Jean-Martin Beaulieu, Larry S Barak, William C Wetsel, Marc G Caron, Raul R Gainetdinov   +5 more
doaj   +2 more sources

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

Pharmaceuticals, 2023
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients.
Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kokot, Antun Koprivanac, Ivan Dobric, Marko Sever, Mario Staresinic, Lovorka Batelja Vuletic, Anita Skrtic, Sven Seiwerth   +24 more
doaj   +1 more source

Dopamine, Immunity, and Disease

Pharmacological Reviews, 2022
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition.
Breana Channer, S. Matt, E. Nickoloff-Bybel, V. Pappa, Yash Agarwal, Jason R Wickman, P. Gaskill   +6 more
semanticscholar   +1 more source

Dopamine Increases the Intrinsic Excitability of Parvalbumin-Expressing Fast-Spiking Cells in the Piriform Cortex

Frontiers in Cellular Neuroscience, 2022
The piriform cortex (PCx) is essential for the adaptive processing of olfactory information. Neuromodulatory systems, including those utilizing serotonin, acetylcholine, noradrenaline, and dopamine, innervate and regulate neuronal activity in the PCx ...
Yasmin Potts, John M. Bekkers
doaj   +1 more source

Automatic Segmentation of Cervical Cells Based on Star-Convex Polygons in Pap Smear Images

Bioengineering, 2022
Cervical cancer is one of the most common cancers that threaten women’s lives, and its early screening is of great significance for the prevention and treatment of cervical diseases.
Yanli Zhao, Chong Fu, Wenchao Zhang, Chen Ye, Zhixiao Wang, Hong-feng Ma   +5 more
doaj   +1 more source

Decoding the dopamine signal in macaque prefrontal cortex: a simulation study using the Cx3Dp simulator. [PDF]

PLoS ONE, 2013
Dopamine transmission in the prefrontal cortex plays an important role in reward based learning, working memory and attention. Dopamine is thought to be released non-synaptically into the extracellular space and to reach distant receptors through ...
Isabelle Ayumi Spühler, Andreas Hauri
doaj   +1 more source