Results 71 to 80 of about 589,499 (392)

Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit [PDF]

The Journal of Biological Chemistry 279, 16 (2004) 15824-30, 2008
The gamma-aminobutyric acid type B (GABAB) receptor is an allosteric complex made of two subunits, GABAB1 (GB1) and GABAB2 (GB2). Both subunits are composed of an extracellular Venus flytrap domain (VFT) and a heptahelical domain (HD). GB1 binds GABA, and GB2 plays a major role in G-protein activation as well as in the high agonist affinity state of ...
arxiv   +1 more source

Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors [PDF]

, 2010
Methylphenidate (MP) and amphetamine (AMPH) are the most frequently prescribed medications for the treatment of attention-deficit/hyperactivity disorder (ADHD).
Bermeo, C., Grandy, David K., Rubinstein, Marcelo, Suchland, K. L., Thanos, P. K., Volkow, N. D., Wang, G. J.   +6 more
core   +1 more source

Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study

BMC Nephrology, 2013
BackgroundRestless Legs Syndrome is very common in hemodialysis patients however there are no comparative studies assessing the effectiveness of a non-pharmacological treatment to a classical treatment on parameters related to syndromes’ severity and ...
C. Giannaki, Giorgos K. Sakkas, C. Karatzaferi, G. Hadjigeorgiou, E. Lavdas, T. Kyriakides, Y. Koutedakis, I. Stefanidis   +7 more
semanticscholar   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Mythology of Parkinson’s disease: from levodopa phobia to dopamine agonist phobia

Медицинский совет, 2020
Any common disease (including Parkinson’s disease) is inevitably overgrown with myths. As a result, not scientifically grounded approaches based on the principles of evidence-based medicine, but irrational ideas, especially often of a pharmacophobic ...
O. S. Levin, A. Sh. Chimagomedova, O. V. Yakovleva   +2 more
doaj   +1 more source

Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis [PDF]

Epilepsia, 2019, 60 (10), pp.2128-2140
Abstract Objective In Genetic Absence Epilepsy Rats From Strasbourg ( GAERS s), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are the consequence of seizure repetition or contribute to the development of epilepsy remains to be clarified.
arxiv   +1 more source

Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]

PLoS Comp. Biol. (2015) 11(2): e1004044, 2014
Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\sim$ 5 $\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine ...
arxiv   +1 more source

Acute and chronic cognitive effects of levodopa and dopamine agonists on patients with Parkinson’s disease: a review

Therapeutic Advances in Psychopharmacology, 2013
The spatiotemporal progression of dopamine depletion in Parkinson’s disease (PD) provides a special model for assessing dopaminergic effects on neural systems with differential baseline dopamine levels.
M. Poletti, U. Bonuccelli
semanticscholar   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielman, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Modeling ADHD in Drosophila: Investigating the Effects of Glucose on Dopamine Production Demonstrated by Locomotion [PDF]

arXiv, 2021
Hyperactivity is one of the hallmakrs of ADHD. Aberrant dopamine signaling is a major theme in ADHD and dopamine production is directly linked to the intensity and persistence of hyperactive conduct. The strength and persistence of hyperactivity responses in Drosophila to startle stimuli were measured in a study to determine the effects of sugar on ...
arxiv