Results 301 to 310 of about 112,056 (332)
Some of the next articles are maybe not open access.
Limited power of dopamine transporter mRNA mapping for predicting dopamine transporter availability
Synapse, 2022AbstractDopamine transporters (DAT) are transmembrane proteins that translocate dopamine from the extracellular space into presynaptic neurons. We aimed to investigate the predictive power of DAT mRNA for DAT protein expression, measured using positron emission tomography (PET). We performed 18F‐FP‐CIT PET scans in 35 healthy individuals.
Kyoungjune Pak +5 more
openaire +2 more sources
Neuroleptics and Dopamine Transporters
Neurochemical Research, 1998The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostriatum and substantia nigra, after ...
T A, Reader +4 more
openaire +2 more sources
Thermal Stability of Dopamine Transporters
The Journal of Membrane Biology, 2015The thermal stabilities of the rat and mouse dopamine transporter (DAT) proteins were studied within the temperature range of 0-37°C. The inactivation of the protein was followed by monitoring changes in radioligand-specific binding. We found that the process followed a rate equation with first-order kinetics and was characterized by having a single ...
Siim, Kukk +2 more
openaire +2 more sources
Dopamine transporters and neuronal injury
Trends in Pharmacological Sciences, 1999The plasma membrane dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) are essential for normal dopamine neurotransmission. DAT terminates the actions of dopamine by rapidly removing dopamine from the synapse, whereas VMAT2 loads cytoplasmic dopamine into vesicles for storage and subsequent release.
G W, Miller +3 more
openaire +2 more sources
Role of dopamine transporter (DAT) in dopamine transport across the nasal mucosa
Life Sciences, 2006Dopamine is a catecholamine neurotransmitter necessary for motor functions. Its deficiency has been observed in several neurological disorders, but replacement of endogenous dopamine via oral or parenteral delivery is limited by poor absorption, rapid metabolism and the inability of dopamine to cross the blood-brain barrier.
Nagendra V, Chemuturi +3 more
openaire +2 more sources
Annals of Neurology, 1996
AbstractDepletion of striatal dopamine (DA) has been hypothesized to explain some of the neurological and psychiatric complications of chronic use of cocaine, including increased risk for neuroleptic‐precipitated movement disorders. We measured levels of DA, as well as two DA nerve terminal indices, namely, the DA transporter (DAT) and the vesicular ...
J M, Wilson +12 more
openaire +2 more sources
AbstractDepletion of striatal dopamine (DA) has been hypothesized to explain some of the neurological and psychiatric complications of chronic use of cocaine, including increased risk for neuroleptic‐precipitated movement disorders. We measured levels of DA, as well as two DA nerve terminal indices, namely, the DA transporter (DAT) and the vesicular ...
J M, Wilson +12 more
openaire +2 more sources
The dopamine transporter proteome
Journal of Neurochemistry, 2006AbstractDopamine (DA) uptake through the neuronal plasma membrane DA transporter (DAT) is essential for the maintenance of normal DA homeostasis in the brain. The DAT‐mediated re‐uptake system limits not only the intensity but also the duration of DA actions at presynaptic and postsynaptic receptors.
openaire +2 more sources
European Journal of Pharmacology, 2000
We have reported that inhibition of protein kinase C blocks the Ca(2+)-independent reverse transport of dopamine mediated by amphetamine. In this study we investigated whether activation of protein kinase C by 12-O-tetradecanoyl phorbol-13-acetate (TPA) would mediate dopamine release through the plasmalemmal dopamine transporter.
R M, Cowell +4 more
openaire +2 more sources
We have reported that inhibition of protein kinase C blocks the Ca(2+)-independent reverse transport of dopamine mediated by amphetamine. In this study we investigated whether activation of protein kinase C by 12-O-tetradecanoyl phorbol-13-acetate (TPA) would mediate dopamine release through the plasmalemmal dopamine transporter.
R M, Cowell +4 more
openaire +2 more sources
Dopamine Transporter Network and Pathways
2004Publisher Summary This chapter explains the dopamine transporter network and pathways. The family of Na + and Cl - dependent transporters that includes the dopamine (DA), and norepinephrine (NE) transporters (DAT and NET, respectively), functions to clear released neurotransmitters from the synaptic cleft.
Rajani, Maiya, R Dayne, Mayfield
openaire +2 more sources