Results 1 to 10 of about 392,840 (300)
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo
Nature Methods, 2020 Dopamine (DA) plays a critical role in the brain, and the ability to directly measure dopaminergic activity is essential for understanding its physiological functions. We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (
Fangmiao Sun +2 more
exaly +2 more sources
Nature Communications, 2020 Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD).
Daisuke Doi +2 more
exaly +2 more sources
Stress and the dopaminergic reward system
Experimental and Molecular Medicine, 2020 Dopamine regulates reward-related behavior through the mesolimbic dopaminergic pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system.
Ja-Hyun Baik
exaly +2 more sources
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
Science Translational Medicine, 2018 Oral treatment with a brain-penetrant NLRP3 inhibitor has protective effects in preclinical models of Parkinson’s disease. Systemic inflammasome inhibitor for Parkinson’s disease Brain accumulation of misfolded α-synuclein, progressive loss of ...
Richard Gordon +2 more
exaly +2 more sources
Cell Death and Differentiation, 2018 Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum.
Eunju Lee, Inhwa Hwang, Je-Wook Yu
exaly +2 more sources
Determinants of dopaminergic neuron loss in Parkinson's disease
FEBS Journal, 2018 The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). Alpha‐synuclein (aSYN) pathology and mitochondrial dysfunction have been implicated in PD pathogenesis ...
D. Surmeier
exaly +2 more sources
An approach for identifying brainstem dopaminergic pathways using resting state functional MRI. [PDF]
, 2014 Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra;
D'Esposito, Mark +3 more
core +20 more sources
Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence
Pharmaceuticals, 2023 Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by ...
Mayara Cecile Nascimento Oliveira +13 more
doaj +1 more source
Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
International Journal of Molecular Sciences, 2021 Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but the ...
F. Pignalosa +10 more
semanticscholar +1 more source
Levosulpiride-induced neurological adverse effects: A prospective study from a tertiary care center
Annals of Indian Academy of Neurology, 2020 Background: Levosulpiride (LS) is a prokinetic drug increasingly used for the gastric motility disorders. Despite its common use for the gastric motility disorder, the tendency to cause parkinsonism and acute dystonias are under-recognized as the major ...
Jacob Joe
doaj +1 more source