Results 1 to 10 of about 297,910 (307)
Polydopamine Nanoparticle‐Mediated Dopaminergic Immunoregulation in Colitis
Advanced Science, 2022 Despite immunosuppression is critical for reducing immune overactivation, existing immunosuppressive agents are largely restricted by low inhibition efficiencies and unpredictable off‐target toxicities.
Juanjuan Li, Sisi Lin, Jinyao Liu
exaly +2 more sources
The Cerebellar Dopaminergic System [PDF]
Frontiers in Systems Neuroscience, 2021 In the central nervous system (CNS), dopamine (DA) is involved in motor and cognitive functions. Although the cerebellum is not been considered an elective dopaminergic region, studies attributed to it a critical role in dopamine deficit-related ...
Paolo Flace +11 more
doaj +4 more sources
Human midbrain organoids reveal the characteristics of axonal mitochondria specific to dopaminergic neurons [PDF]
Molecular BrainMitochondrial dysfunction and abnormalities in mitochondrial quality control contribute to the development of neurodegenerative diseases. Parkinson’s disease is a neurodegenerative disease that causes motor problems mainly due to the loss of dopaminergic
Akihiko Nishijima +8 more
doaj +2 more sources
Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?
Future Science OA, 2021 Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in the aging population. Crucially, neurodegeneration of dopaminergic neurons in PD is associated with chronic inflammation and glial activation.
Parisa Gazerani
doaj +1 more source
Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores [PDF]
Journal of the Serbian Chemical Society, 2019 A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group
Jevtić Ivana I. +3 more
doaj +1 more source
Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence
Pharmaceuticals, 2023 Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by ...
Mayara Cecile Nascimento Oliveira +13 more
doaj +1 more source
Frontiers in Neuroscience, 2016 Evidence of inflammation has been consistently associated with pathology in Parkinson’s disease (PD)-affected brains, and has been suggested as a causative factor.
Douglas Gordon Walker +6 more
doaj +1 more source
Two eARCHT3.0 Lines for Optogenetic Silencing of Dopaminergic and Serotonergic Neurons
Frontiers in Neural Circuits, 2019 Dopaminergic and serotonergic neurons modulate and control processes ranging from reward signaling to regulation of motor outputs. Further, dysfunction of these neurons is involved in both degenerative and psychiatric disorders.
Alexandra Krol +11 more
doaj +1 more source
Journal of Parkinson’s Disease, 2018 Currently all aspects of Parkinson’s disease (PD) treatment are less than ideal and would benefit from new interventions. We focus on problems associated with brain neurotransmitters amenable to more specific subreceptor and temporal manipulation.
Nutt, John G., Bohnen, Nicolaas I.
openaire +3 more sources
Levosulpiride-induced neurological adverse effects: A prospective study from a tertiary care center
Annals of Indian Academy of Neurology, 2020 Background: Levosulpiride (LS) is a prokinetic drug increasingly used for the gastric motility disorders. Despite its common use for the gastric motility disorder, the tendency to cause parkinsonism and acute dystonias are under-recognized as the major ...
Jacob Joe
doaj +1 more source