Results 1 to 10 of about 240,256 (373)
Polydopamine Nanoparticle‐Mediated Dopaminergic Immunoregulation in Colitis
Advanced Science, 2022 Despite immunosuppression is critical for reducing immune overactivation, existing immunosuppressive agents are largely restricted by low inhibition efficiencies and unpredictable off‐target toxicities.
Juanjuan Li +6 more
doaj +1 more source
Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence
Pharmaceuticals, 2023 Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by ...
Mayara Cecile Nascimento Oliveira +13 more
doaj +1 more source
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo
Nature Methods, 2020 Dopamine (DA) plays a critical role in the brain, and the ability to directly measure dopaminergic activity is essential for understanding its physiological functions. We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (
Fangmiao Sun +15 more
semanticscholar +1 more source
Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
International Journal of Molecular Sciences, 2021 Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but the ...
F. Pignalosa +10 more
semanticscholar +1 more source
Stress and the dopaminergic reward system
Experimental and Molecular Medicine, 2020 Dopamine regulates reward-related behavior through the mesolimbic dopaminergic pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system.
J. Baik
semanticscholar +1 more source
Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?
Future Science OA, 2021 Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in the aging population. Crucially, neurodegeneration of dopaminergic neurons in PD is associated with chronic inflammation and glial activation.
Parisa Gazerani
doaj +1 more source
Nature Communications, 2020 Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD).
D. Doi +10 more
semanticscholar +1 more source
Levosulpiride-induced neurological adverse effects: A prospective study from a tertiary care center
Annals of Indian Academy of Neurology, 2020 Background: Levosulpiride (LS) is a prokinetic drug increasingly used for the gastric motility disorders. Despite its common use for the gastric motility disorder, the tendency to cause parkinsonism and acute dystonias are under-recognized as the major ...
Jacob Joe
doaj +1 more source
Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores [PDF]
Journal of the Serbian Chemical Society, 2019 A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group
Jevtić Ivana I. +3 more
doaj +1 more source
European Journal of Nuclear Medicine and Molecular Imaging, 2020 Purpose This joint practice guideline or procedure standard was developed collaboratively by the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
S. Morbelli +27 more
semanticscholar +1 more source