Results 1 to 10 of about 398,911 (393)
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo
Nature Methods, 2020 Dopamine (DA) plays a critical role in the brain, and the ability to directly measure dopaminergic activity is essential for understanding its physiological functions. We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (
Fangmiao Sun, Jingheng Zhou
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Nature Communications, 2020 Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD).
Daisuke Doi +2 more
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Stress and the dopaminergic reward system
Experimental and Molecular Medicine, 2020 Dopamine regulates reward-related behavior through the mesolimbic dopaminergic pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system.
Ja-Hyun Baik
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Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
Science Translational Medicine, 2018 Oral treatment with a brain-penetrant NLRP3 inhibitor has protective effects in preclinical models of Parkinson’s disease. Systemic inflammasome inhibitor for Parkinson’s disease Brain accumulation of misfolded α-synuclein, progressive loss of ...
Richard Gordon +2 more
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Cell Death and Differentiation, 2018 Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum.
Eunju Lee, Inhwa Hwang, Je-Wook Yu
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Locus coeruleus and dopaminergic consolidation of everyday memory
Nature, 2016 The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect ...
Tomonori Takeuchi +2 more
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Determinants of dopaminergic neuron loss in Parkinson's disease
FEBS Journal, 2018 The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). Alpha‐synuclein (aSYN) pathology and mitochondrial dysfunction have been implicated in PD pathogenesis ...
D. Surmeier
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PLoS ONE, 2011 Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a ...
Russell C Addis +5 more
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Nature Methods, 2023 Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition.
Daniel Reumann +17 more
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Polydopamine Nanoparticle‐Mediated Dopaminergic Immunoregulation in Colitis
Advanced Science, 2022 Despite immunosuppression is critical for reducing immune overactivation, existing immunosuppressive agents are largely restricted by low inhibition efficiencies and unpredictable off‐target toxicities.
Juanjuan Li +6 more
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