Brain neurons as quantum computers: {\it in vivo} support of background physics [PDF]
Internatioanl Journal of Modern Physics C: 14, 897-904 (2003), 2003 The question: whether quantum coherent states can sustain decoherence, heating and dissipation over time scales comparable to the dynamical timescales of the brain neurons, is actively discussed in the last years. Positive answer on this question is crucial, in particular, for consideration of brain neurons as quantum computers.
arxiv +1 more source
Exploring Neuronal Bistability at the Depolarization Block [PDF]
(2012) PLoS ONE 7(8): e42811, 2012 Many neurons display bistability - coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in ...
arxiv +1 more source
Self-supervised Learning for Segmentation and Quantification of Dopamine Neurons in Parkinson's Disease [PDF]
arXiv, 2023 Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is one of the most important indexes in evaluating drug efficacy in PD animal models.
arxiv
Representation learning with reward prediction errors [PDF]
arXiv, 2021 The Reward Prediction Error hypothesis proposes that phasic activity in the midbrain dopaminergic system reflects prediction errors needed for learning in reinforcement learning. Besides the well-documented association between dopamine and reward processing, dopamine is implicated in a variety of functions without a clear relationship to reward ...
arxiv
Can linking the recall system to addiction enable a better understanding of the dopaminergic pathway? [PDF]
arXiv, 2022 Human addiction, as a learned behaviour, has and is constantly being treated psychologically, with specific and timely interventions from Neuroscience. We endorse that human addiction can receive further boost as regards treatment, when we firmly understand how it works from a quantum scale. This is majorly because the dopaminergic pathway (DP) that is
arxiv
Postnatal functional inactivation of the ventral subiculum enhances dopaminergic responses in the core part of the nucleus accumbens following ketamine injection in adult rats [PDF]
, 2020 For almost two decades schizophrenia has been considered to be a functional disconnection disorder. This functional disconnectivity between several brain regions could have a neurodevelopmental origin. Various approaches suggest the ventral subiculum (SUB) is a particular target region for neurodevelopemental disturbances in schizophrenia.
arxiv +1 more source
Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis [PDF]
Epilepsia, 2019, 60 (10), pp.2128-2140Abstract Objective In Genetic Absence Epilepsy Rats From Strasbourg ( GAERS s), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are the consequence of seizure repetition or contribute to the development of epilepsy remains to be clarified.
arxiv +1 more source
Freezing of Gait as a Complication of Pallidal Deep Brain Stimulation in DYT- KMT2B Patients with Evidence of Striatonigral Degeneration [PDF]
Mov Disord Clin Pract. 2022 Aug 9;9(7):992-996Background: Mutations in KMT2B are a recognized cause of early-onset complex dystonia, with deep brain stimulation (DBS) of the internal globus pallidus (GPi-DBS) being an effective treatment. However, gait impairment, particularly freezing of gait (FOG), remains a significant challenge in DYT-KMT2B patients post-DBS.
arxiv +1 more source
High Accuracy Classification of Parkinson's Disease through Shape Analysis and Surface Fitting in $^{123}$I-Ioflupane SPECT Imaging [PDF]
, 2017 Early and accurate identification of parkinsonian syndromes (PS) involving presynaptic degeneration from non-degenerative variants such as Scans Without Evidence of Dopaminergic Deficit (SWEDD) and tremor disorders, is important for effective patient management as the course, therapy and prognosis differ substantially between the two groups.
arxiv +1 more source
Controlled Forgetting: Targeted Stimulation and Dopaminergic Plasticity Modulation for Unsupervised Lifelong Learning in Spiking Neural Networks [PDF]
, 2019 Stochastic gradient descent requires that training samples be drawn from a uniformly random distribution of the data. For a deployed system that must learn online from an uncontrolled and unknown environment, the ordering of input samples often fails to meet this criterion, making lifelong learning a difficult challenge.
arxiv +1 more source