An approach for identifying brainstem dopaminergic pathways using resting state functional MRI. [PDF]
, 2014 Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra;
D'Esposito, Mark +3 more
core +10 more sources
CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. [PDF]
, 2017 Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain
Choi, Eui-Ju +8 more
core +4 more sources
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]
, 2018 The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro +7 more
core +3 more sources
Frontiers in Systems Neuroscience, 2011 The onset of Parkinson's disease (PD) is characterized by focal motor features in one body part, which are usually correlated with greater dopaminergic depletion in the contralateral posterior putamen. The role of dopamine (DA) hemispheric differences in
Javier eBlesa +14 more
doaj +1 more source
Scientific Reports, 2022 Wnt/β-catenin signaling contributes to patterning, proliferation, and differentiation throughout vertebrate neural development. Wnt/β-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in
Markus Westphal +4 more
doaj +1 more source
Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes
Frontiers in Physiology, 2022 Serotonin (5-hydroxytryptamine, 5-HT) is a phylogenetically conserved modulator of numerous aspects of neural functions. Serotonergic neurons in the dorsal and median raphe nucleus provide ascending innervation to the entire forebrain and midbrain ...
Toshiyuki Fujita +6 more
doaj +1 more source
Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]
, 2014 Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
A Garcia-Espana +75 more
core +5 more sources
Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration
Frontiers in Physiology, 2018 Male courtship in Drosophila melanogaster is a sexually dimorphic innate behavior that is hardwired in the nervous system. Understanding the neural mechanism of courtship behavior requires the anatomical and functional characterization of all the neurons
Shreyas Jois +3 more
doaj +1 more source
Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. [PDF]
PLoS ONE, 2010 Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human alpha-synuclein in C.
Pengxiu Cao +6 more
doaj +1 more source
The Dopaminergic Midbrain Encodes the Expected Certainty about Desired Outcomes [PDF]
, 2014 Dopamine plays a key role in learning; however, its exact function in decision making and choice remains unclear. Recently, we proposed a generic model based on active (Bayesian) inference wherein dopamine encodes the precision of beliefs about optimal ...
Dolan, Ray +4 more
core +2 more sources