The Cerebellar Dopaminergic System [PDF]
Frontiers in Systems Neuroscience, 2021 In the central nervous system (CNS), dopamine (DA) is involved in motor and cognitive functions. Although the cerebellum is not been considered an elective dopaminergic region, studies attributed to it a critical role in dopamine deficit-related ...
Paolo Flace +11 more
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An approach for identifying brainstem dopaminergic pathways using resting state functional MRI. [PDF]
, 2014 Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra;
D'Esposito, Mark +3 more
core +28 more sources
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism [PDF]
Journal of Neuroscience, 2016 E. Aflaki +17 more
semanticscholar +3 more sources
Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence
Pharmaceuticals, 2023 Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by ...
Mayara Cecile Nascimento Oliveira +13 more
doaj +1 more source
Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
International Journal of Molecular Sciences, 2021 Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but the ...
F. Pignalosa +10 more
semanticscholar +1 more source
Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?
Future Science OA, 2021 Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in the aging population. Crucially, neurodegeneration of dopaminergic neurons in PD is associated with chronic inflammation and glial activation.
Parisa Gazerani
doaj +1 more source
European Journal of Nuclear Medicine and Molecular Imaging, 2020 Purpose This joint practice guideline or procedure standard was developed collaboratively by the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
S. Morbelli +27 more
semanticscholar +1 more source
Dopaminergic therapy in aphasia [PDF]
Aphasiology, 2013 The dopaminergic system is involved in a wide range of cognitive functions including motor control, reward, memory, attention, problem-solving and learning. This has stimulated interest in investigating the potential of dopaminergic drugs as cognitive enhancers in aphasic patients.To discuss the evidence for the use of dopaminergic agents in patients ...
Gill, SK, Leff, AP
openaire +3 more sources
Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores [PDF]
Journal of the Serbian Chemical Society, 2019 A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group
Jevtić Ivana I. +3 more
doaj +1 more source
Levosulpiride-induced neurological adverse effects: A prospective study from a tertiary care center
Annals of Indian Academy of Neurology, 2020 Background: Levosulpiride (LS) is a prokinetic drug increasingly used for the gastric motility disorders. Despite its common use for the gastric motility disorder, the tendency to cause parkinsonism and acute dystonias are under-recognized as the major ...
Jacob Joe
doaj +1 more source