Results 11 to 20 of about 134,791 (125)

Polydopamine Nanoparticle‐Mediated Dopaminergic Immunoregulation in Colitis

Advanced Science, 2022
Despite immunosuppression is critical for reducing immune overactivation, existing immunosuppressive agents are largely restricted by low inhibition efficiencies and unpredictable off‐target toxicities.
Juanjuan Li, Weiliang Hou, Sisi Lin, Lu Wang, Chao Pan, Feng Wu, Jinyao Liu   +6 more
doaj   +1 more source

Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence

Pharmaceuticals, 2023
Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by ...
Mayara Cecile Nascimento Oliveira, Ikla Lima Cavalcante, Alana Natalícia de Araújo, Aline Matilde Ferreira dos Santos, Renata Priscila Barros de Menezes, Chonny Herrera-Acevedo, Natália Ferreira de Sousa, Jailane de Souza Aquino, José Maria Barbosa-Filho, Ricardo Dias de Castro, Reinaldo Nóbrega Almeida, Luciana Scotti, Marcus Tullius Scotti, Mirian Graciela Da Silva Stiebbe Salvadori   +13 more
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Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?

Future Science OA, 2021
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in the aging population. Crucially, neurodegeneration of dopaminergic neurons in PD is associated with chronic inflammation and glial activation.
Parisa Gazerani
doaj   +1 more source

Levosulpiride-induced neurological adverse effects: A prospective study from a tertiary care center

Annals of Indian Academy of Neurology, 2020
Background: Levosulpiride (LS) is a prokinetic drug increasingly used for the gastric motility disorders. Despite its common use for the gastric motility disorder, the tendency to cause parkinsonism and acute dystonias are under-recognized as the major ...
Jacob Joe
doaj   +1 more source

Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores [PDF]

Journal of the Serbian Chemical Society, 2019
A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group
Jevtić Ivana I., Penjišević Jelena Z., Ivanović Milovan D., Kostić-Rajačić Slađana V.   +3 more
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Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations

Frontiers in Cellular Neuroscience, 2012
The increased risk and prevalence of lacunar stroke and Parkinson's disease makes the search for better experimental models an important requirement for translational research.
Vilma Consuelo Muñeton-Gomez, Ernesto eDoncel-Perez, Ana Patricia eFernandez, Julia eSerrano Masa, Andrea ePozo-Rodrigalvarez, Lara eVellosillo-Huerta, Julian eScott Taylor, Gloria Patricia eCardona-Gomez, Manuel eNieto-Sampedro, Manuel eNieto-Sampedro, Ricardo eMartinez-Murillo   +10 more
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Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion. A possible compensatory mechanism in Parkinson’s disease

Frontiers in Systems Neuroscience, 2011
The onset of Parkinson's disease (PD) is characterized by focal motor features in one body part, which are usually correlated with greater dopaminergic depletion in the contralateral posterior putamen. The role of dopamine (DA) hemispheric differences in
Javier eBlesa, Javier eBlesa, Carlos eJuri, Carlos eJuri, Miguel Ángel eGarcía-Cabezas, Miguel Ángel eGarcía-Cabezas, Rebeca eAdánez, Rebeca eAdánez, Miguel Ángel eSánchez-González, Miguel Ángel eSánchez-González, Carmen eCavada, Carmen eCavada, José A. eObeso, José A. eObeso, José A. eObeso   +14 more
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Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration

Frontiers in Physiology, 2018
Male courtship in Drosophila melanogaster is a sexually dimorphic innate behavior that is hardwired in the nervous system. Understanding the neural mechanism of courtship behavior requires the anatomical and functional characterization of all the neurons
Shreyas Jois, Yick Bun Chan, Maria Paz Fernandez, Adelaine Kwun-Wai Leung   +3 more
doaj   +1 more source

Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes

Frontiers in Physiology, 2022
Serotonin (5-hydroxytryptamine, 5-HT) is a phylogenetically conserved modulator of numerous aspects of neural functions. Serotonergic neurons in the dorsal and median raphe nucleus provide ascending innervation to the entire forebrain and midbrain ...
Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J. Homma, Shinji Yamaguchi   +6 more
doaj   +1 more source

Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish

Scientific Reports, 2022
Wnt/β-catenin signaling contributes to patterning, proliferation, and differentiation throughout vertebrate neural development. Wnt/β-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in
Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Driever   +4 more
doaj   +1 more source