Results 21 to 30 of about 243,277 (347)
Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. [PDF]
PLoS ONE, 2010 Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human alpha-synuclein in C.
Pengxiu Cao +6 more
doaj +1 more source
Locus coeruleus and dopaminergic consolidation of everyday memory
Nature, 2016 The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect ...
T. Takeuchi +10 more
semanticscholar +1 more source
THE DOPAMINERGIC SYSTEM IN HYPERTENSION
Clinical and Experimental Hypertension, 2001 Dopamine exerts cardiovascular and renal actions mediated through interaction with specific dopamine receptors. Dopamine receptors are cell surface receptors coupled to G-proteins and classified into two main super families based on biochemical, pharmacological and molecular characteristics. The dopamine D1-like receptor super family includes D1 and D5
AMENTA, Francesco +4 more
openaire +4 more sources
Caffeine and Primary (Migraine) Headaches—Friend or Foe?
Frontiers in Neurology, 2019 Background: The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system ...
Karl B. Alstadhaug +3 more
doaj +1 more source
Molecular Brain, 2021 Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial ...
Mutsumi Yokota +7 more
doaj +1 more source
Journal of Parkinson’s Disease, 2018 Currently all aspects of Parkinson’s disease (PD) treatment are less than ideal and would benefit from new interventions. We focus on problems associated with brain neurotransmitters amenable to more specific subreceptor and temporal manipulation.
Nicolaas I. Bohnen, John G. Nutt
openaire +4 more sources
Frontiers in Neuroscience, 2014 Clinical trials engrafting human fetal ventral mesencephalic tissue have demonstrated, in principle, that cell replacement therapy provides substantial long-lasting improvement of motor impairments generated by Parkinson’s Disease.
John eCave +5 more
doaj +1 more source
Analytical Cellular Pathology, 2021 An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu +7 more
doaj +1 more source
Cell Death and Differentiation, 2018 Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum.
Eunju Lee +7 more
semanticscholar +1 more source
Dopaminergic Retinal Cell Loss and Visual Dysfunction in Parkinson Disease
Annals of Neurology, 2020 Considering the demonstrated implication of the retina in Parkinson disease (PD) pathology and the importance of dopaminergic cells in this tissue, we aimed to analyze the state of the dopaminergic amacrine cells and some of their main postsynaptic ...
Isabel Ortuño-Lizarán +6 more
semanticscholar +1 more source