Results 21 to 30 of about 297,910 (307)

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO, CONTE, MICHELA, DE VINCENTIIS, Marco, DE VIRGILIO, ARMANDO, FABBRINI, Giovanni, GALLO, Andrea, GRECO, Antonio, INGHILLERI, Maurizio, RIZZO, MARIA IDA, ROSATO, CHIARA   +9 more
core   +1 more source

Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations

Frontiers in Cellular Neuroscience, 2012
The increased risk and prevalence of lacunar stroke and Parkinson's disease makes the search for better experimental models an important requirement for translational research.
Vilma Consuelo Muñeton-Gomez, Ernesto eDoncel-Perez, Ana Patricia eFernandez, Julia eSerrano Masa, Andrea ePozo-Rodrigalvarez, Lara eVellosillo-Huerta, Julian eScott Taylor, Gloria Patricia eCardona-Gomez, Manuel eNieto-Sampedro, Manuel eNieto-Sampedro, Ricardo eMartinez-Murillo   +10 more
doaj   +1 more source

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

Molecular Brain, 2021
Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial ...
Mutsumi Yokota, Soichiro Kakuta, Takahiro Shiga, Kei-ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koike   +7 more
doaj   +1 more source

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

Analytical Cellular Pathology, 2021
An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu, Weibo Shi, Yingmin Li, Shanyong Yi, Yang Li, Xia Liu, Bin Cong, Guanglong He   +7 more
doaj   +1 more source

Caffeine and Primary (Migraine) Headaches—Friend or Foe?

Frontiers in Neurology, 2019
Background: The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system ...
Karl B. Alstadhaug, Karl B. Alstadhaug, Anna P. Andreou, Anna P. Andreou   +3 more
doaj   +1 more source

Adult subventricular zone neural stem cells as a potential source of dopaminergic replacement neurons

Frontiers in Neuroscience, 2014
Clinical trials engrafting human fetal ventral mesencephalic tissue have demonstrated, in principle, that cell replacement therapy provides substantial long-lasting improvement of motor impairments generated by Parkinson’s Disease.
John eCave, John eCave, Meng eWang, Meng eWang, Harriet eBaker, Harriet eBaker   +5 more
doaj   +1 more source

Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward [PDF]

, 2011
Dopamine release in cortical and subcortical structures plays a central role in reward-related neural processes. Within this context, dopaminergic inputs are commonly assumed to play an activating role, facilitating behavioral and cognitive operations ...
Böhler, Nico, Heinze, Hans-Jochen, Hopf, Jens-Max, Krebs, Ruth, Noesselt, Toemme, Schoenfeld, Mircea A, Stoppel, Christian M   +6 more
core   +2 more sources

Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease [PDF]

, 2003
Background: Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown. Methods: We conducted a five-
Krack, P., Batir, A., Van Blercom, N., Chabardes, S., Fraix, V., Ardouin, C., Koudsie, A., Limousin, P.D., Benazzouz, A., LeBas, J.F., Benabid, A.-L., Pollak, P.   +11 more
core   +4 more sources

Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations

FEBS Open Bio, 2017
Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock ...
Yutaro Ueoka, Makoto Hiroi, Takashi Abe, Tetsuya Tabata   +3 more
doaj   +1 more source

Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. [PDF]

PLoS ONE, 2013
Dopaminergic differentiation of embryonic stem cells (ESCs) gains more and more attention worldwide owing to its potential use for neurorestorative therapy for the treatment of Parkinson's disease.
Na Ni, Yaohua Hu, Huixia Ren, Chuanming Luo, Peng Li, Jian-Bo Wan, Huanxing Su   +6 more
doaj   +1 more source