Results 31 to 40 of about 243,277 (347)
Determinants of dopaminergic neuron loss in Parkinson's disease
The FEBS Journal, 2018 The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). Alpha‐synuclein (aSYN) pathology and mitochondrial dysfunction have been implicated in PD pathogenesis ...
D. Surmeier
semanticscholar +1 more source
Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review).
International Journal of Molecular Medicine, 2018 Oxidative stress is increasingly recognized as a central event contributing to the degeneration of dopaminergic neurons in the pathogenesis of Parkinson's disease (PD). Although reactive oxygen species (ROS) production is implicated as a causative factor
Ji-dong Guo +4 more
semanticscholar +1 more source
Two eARCHT3.0 Lines for Optogenetic Silencing of Dopaminergic and Serotonergic Neurons
Frontiers in Neural Circuits, 2019 Dopaminergic and serotonergic neurons modulate and control processes ranging from reward signaling to regulation of motor outputs. Further, dysfunction of these neurons is involved in both degenerative and psychiatric disorders.
Alexandra Krol +11 more
doaj +1 more source
Rapid signaling in distinct dopaminergic axons during locomotion and reward
Nature, 2016 Dopaminergic projection axons from the midbrain to the striatum are crucial for motor control, as their degeneration in Parkinson disease results in profound movement deficits. Paradoxically, most recording methods report rapid phasic dopamine signalling
M. Howe, D. Dombeck
semanticscholar +1 more source
Frontiers in Neuroscience, 2016 Evidence of inflammation has been consistently associated with pathology in Parkinson’s disease (PD)-affected brains, and has been suggested as a causative factor.
Douglas Gordon Walker +6 more
doaj +1 more source
Beta burst dynamics in Parkinson’s disease OFF and ON dopaminergic medication
Brain : a journal of neurology, 2017 Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with Parkinson’s disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms ...
G. Tinkhauser +5 more
semanticscholar +1 more source
Electrical and Ca2+ signaling in dendritic spines of substantia nigra dopaminergic neurons
eLife, 2016 Little is known about the density and function of dendritic spines on midbrain dopamine neurons, or the relative contribution of spine and shaft synapses to excitability.
Travis A Hage, Yujie Sun, Zayd M Khaliq
doaj +1 more source
A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala
Biology of Sex Differences, 2022 Highlights Cell-type specific labeling of VTA-to-BLA dopaminergic axons and synaptic boutons in mice The intensity of dopaminergic innervation in BLA is intermediate between those in PFC and NAC Dopaminergic axon density in BLA and the size of BLA are ...
Matthew T. C. Manion +2 more
doaj +1 more source
Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. [PDF]
PLoS ONE, 2013 Dopaminergic differentiation of embryonic stem cells (ESCs) gains more and more attention worldwide owing to its potential use for neurorestorative therapy for the treatment of Parkinson's disease.
Na Ni +6 more
doaj +1 more source
Dopaminergic Mechanisms in Adhd
Pediatric Neurology Briefs, 2014 Investigators at Addenbrooke's Hospital, University of Cambridge, UK, and centers in Germany and France examined the neural mechanisms underlying attention deficits associated with ADHD and their reversal with a single dose of methylphenidate (MPH).
John Millichap, J. G. Millichap
openaire +4 more sources