Results 41 to 50 of about 392,840 (300)
Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration [PDF]
, 2016 Background: Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel ...
Antonioli, Luca +13 more
core +3 more sources
Rapid signaling in distinct dopaminergic axons during locomotion and reward
Nature, 2016 Dopaminergic projection axons from the midbrain to the striatum are crucial for motor control, as their degeneration in Parkinson disease results in profound movement deficits. Paradoxically, most recording methods report rapid phasic dopamine signalling
M. Howe, D. Dombeck
semanticscholar +1 more source
The Dopaminergic Midbrain Encodes the Expected Certainty about Desired Outcomes [PDF]
, 2014 Dopamine plays a key role in learning; however, its exact function in decision making and choice remains unclear. Recently, we proposed a generic model based on active (Bayesian) inference wherein dopamine encodes the precision of beliefs about optimal ...
Dolan, Ray +4 more
core +2 more sources
Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. [PDF]
PLoS ONE, 2013 Dopaminergic differentiation of embryonic stem cells (ESCs) gains more and more attention worldwide owing to its potential use for neurorestorative therapy for the treatment of Parkinson's disease.
Na Ni +6 more
doaj +1 more source
Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease [PDF]
, 2003 Background: Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown. Methods: We conducted a five-
Krack, P. +11 more
core +4 more sources
Beta burst dynamics in Parkinson’s disease OFF and ON dopaminergic medication
Brain : a journal of neurology, 2017 Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with Parkinson’s disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms ...
G. Tinkhauser +5 more
semanticscholar +1 more source
Electrical and Ca2+ signaling in dendritic spines of substantia nigra dopaminergic neurons
eLife, 2016 Little is known about the density and function of dendritic spines on midbrain dopamine neurons, or the relative contribution of spine and shaft synapses to excitability.
Travis A Hage, Yujie Sun, Zayd M Khaliq
doaj +1 more source
IBRO Neuroscience Reports, 2022 SH-SY5Y is a cell line derived from human neuroblastoma. It is one of the most widely used in vitro models to study Parkinson’s disease. Surprisingly, it has been found that it does not develop a dopaminergic phenotype after differentiation, questioning ...
Angel Carvajal-Oliveros +5 more
doaj +1 more source
, 2019 Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood.
Anichtchik, O. +12 more
core +1 more source
Dopaminergic symptoms in migraine [PDF]
Neurological Sciences, 2013 Migraine pain is often preceded, accompanied and followed by dopaminergic symptoms (premonitory yawning and somnolence, accompanying nausea and vomiting, postdromal somnolence, euphoria and polyuria). After reviewing evidence from pharmacological, biochemical, genetic and animal experimental studies on the relationship between dopamine and migraine ...
Cinzia Aurilia +3 more
openaire +2 more sources