Results 141 to 150 of about 835,318 (379)

Creativity and Delusions: A Neurocomputational Approach [PDF]

arXiv, 2000
Thinking is one of the most interesting mental processes. Its complexity is sometimes simplified and its different manifestations are classified into normal and abnormal, like the delusional and disorganized thought or the creative one. The boundaries between these facets of thinking are fuzzy causing difficulties in medical, academic, and ...
arxiv  

Direct conversion of human fibroblasts to dopaminergic neurons

Proceedings of the National Academy of Sciences of the United States of America, 2011
Recent reports demonstrate that somatic mouse cells can be directly converted to other mature cell types by using combined expression of defined factors. Here we show that the same strategy can be applied to human embryonic and postnatal fibroblasts.
U. Pfisterer, A. Kirkeby, Olof Torper, J. Wood, Jenny Nelander, A. Dufour, A. Björklund, O. Lindvall, Johan Jakobsson, M. Parmar   +9 more
semanticscholar   +1 more source

Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay, Shlomit Katzav, Danielle Wasserman, Valentina Gnoni, Anat Mirelman, Riva Tauman   +5 more
wiley   +1 more source

Calcium Entry and α-Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

Journal of Neuroscience, 2013
The core motor symptoms of Parkinson's disease (PD) are attributable to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Mitochondrial oxidant stress is widely viewed a major factor in PD pathogenesis.
Dilyan I. Dryanovski, Jaime N. Guzmán, Zhong Xie, Daniel J Galteri, L. Volpicelli-Daley, V. Lee, Richard J. Miller, P. Schumacker, D. Surmeier   +8 more
semanticscholar   +1 more source

Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase ...
Verena Dzialas, Gérard N. Bischof, Kathrin Möllenhoff, Alexander Drzezga, Thilo van Eimeren   +4 more
wiley   +1 more source

Biophysics of risk aversion based on neurotransmitter receptor theory [PDF]

Neuro Endocrinol Lett. 2008 Aug;29(4):399-404. http://node.nel.edu/?node_id=7744, 2011
Decision under risk and uncertainty has been attracting attention in neuroeconomics and neuroendocrinology of decision-making. This paper demonstrated that the neurotransmitter receptor theory-based value (utility) function can account for human and animal risk-taking behavior.
arxiv  

Single dopaminergic neurons that modulate aggression in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, 2013
Monoamines, including dopamine (DA), have been linked to aggression in various species. However, the precise role or roles served by the amine in aggression have been difficult to define because dopaminergic systems influence many behaviors, and all can ...
O. Alekseyenko, Yick-Bun Chan, Ran Li, E. Kravitz   +3 more
semanticscholar   +1 more source

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

Neurobiology of Disease, 2014
Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells.
Jun-Shiao Chou, Chu-Yu Chen, Ying-Ling Chen, Yi-Hsin Weng, Tu-Hsueh Yeh, Chin-Song Lu, Ya-Ming Chang, Hung-Li Wang   +7 more
doaj  

Influence of nicotine and alcohol on sleep latency: the reward-attention circuit model [PDF]

arXiv, 2019
We previously developed a neurocomputational model called the reward-attention circuit, which has been used to investigate the separate effects of nicotine and alcohol on attention focus. The model is based on known circuits linking midbrain dopaminergic neurons to the thalamocortical loop and is sufficiently versatile to capture diverse phenomena.
arxiv  

vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain

The Journal of comparative neurology, 2014
Throughout the vertebrate lineage, dopaminergic neurons form important neuromodulatory systems that influence motor behavior, mood, cognition, and physiology.
Alida Filippi, T. Mueller, W. Driever
semanticscholar   +1 more source