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Noradrenergic Modulation on Dopaminergic Neurons
Neurotoxicity Research, 2018It is now well accepted that there is a close relationship between noradrenergic and dopaminergic neurons in the brain, especially referring to the modulation of the locus coeruleus-norepinephrine (LC-NE) system on dopamine transmission. The disturbance of this modulation may contribute to neurodegeneration of dopaminergic neurons in Parkinson's ...
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The organization of dopaminergic and non-dopaminergic mesencephalo-cortical neurons in the rat
Brain Research, 1982The dopamine containing mesencephalo-cortical pathway was studied in the rat by means of a combined retrograde fluorescent tracing and catecholamine histofluorescence technique. After large injections of the fluorescent retrograde tracer, Evans blue, into the frontal cortex, many neural somata of the ventral midbrain tegmentum were retrogradely labeled;
Albanese, Alberto, Bentivoglio, M.
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A Diet for Dopaminergic Neurons?
2009Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive ...
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Dopaminergic Neurons in the Cat Retina
Optometry and Vision Science, 1988ABSTRACT Dopaminergic neurons have been directly visualized in the flat mount cat retina with an immunohistochemical technique that uses antisera directed to the enzyme tyrosine hydroxylase. In a previous study, three specific neuronal populations‐amacrine cells, displaced amacrine (DA) cells, and interplexiform (IP) cells‐were ...
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Development of dopaminergic neurons in the mammalian brain
Cellular and Molecular Life Sciences CMLS, 2006Dopaminergic neurons in the mammalian brain have received substantial attention in the past given their fundamental role in several body functions and behaviours. The largest dopaminergic population is found in two nuclei of the ventral midbrain. Cells of the substantia nigra pars compacta are involved in the control of voluntary movements and postural
N, Prakash, W, Wurst
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Regulatory aspects of nigrostriatal dopaminergic neurons
Experimental Brain Research, 1992In the urethane-anesthetized rat, electrical stimulation (10 Hz, 30 s, 250 microA) of the medial forebrain bundle (MFB), at 20-min intervals over an 8-h period, combined with intracerebral microdialysis in the striatum caused: an undiminished increase in the release of dopamine (DA) with each stimulation episode; a decreased efflux of 3,4 ...
P, Miu +3 more
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Aberrant accumulation of serotonin in dopaminergic neurons
Neuroscience Letters, 2006Gene targeting approaches greatly facilitate insight into the functioning of monoamine transporters, the targets of potent antidepressants. The serotonin transporter (5-HTT) is the molecular target of a large number of antidepressants. To assess the clearance of serotonin (5-HT) in the absence of the 5-HTT, we have generated double knockout mice ...
Rainald, Mössner +4 more
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How to make a mesodiencephalic dopaminergic neuron
Nature Reviews Neuroscience, 2007Dopaminergic neurons located in the ventral mesodiencephalon are essential for the control of voluntary movement and the regulation of emotion, and are severely affected in neurodegenerative diseases such as Parkinson's disease. Recent advances in molecular biology and mouse genetics have helped to unravel the mechanisms involved in the development of ...
Marten P, Smidt, J Peter H, Burbach
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Development of the dopaminergic neurons in the rodent brainstem
Experimental Neurology, 2005The loss of dopaminergic (DA) neurons in the ventral midbrain is the principal cause of Parkinson's disease. The search for candidate molecules that promote the genesis and survival capacities of DA neurons is a major area of investigation and hope. A better characterization of the developmental pathways that govern the specification, differentiation ...
Vitalis, Tania +2 more
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Opiate receptors on mesolimbic dopaminergic neurons
Neuroscience Letters, 1978Abstract Following electrocoagulation of dopaminergic cell bodies of the mesolimbic system, [ 3 H]naloxone binding decreases significantly in septum and nucleus accumbens. The latter effect is also observed after local injection of 6-hydroxydopamine.
H, Pollard +4 more
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