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SIX2-Mediated Microglial M2 Polarization and Exosomal miR-3470b Delivery Protect Dopaminergic Neurons in Parkinson's Disease. [PDF]

CNS Neurosci Ther
Kan JS, Cao XY, Ye YX, Huang XX, Sun GJ, Gao J.   +5 more
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Dopaminergic neurons

The International Journal of Biochemistry & Cell Biology, 2005
Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Shankar J, Chinta, Julie K, Andersen
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Dopaminergic neurons intrinsic to the striatum

Journal of Neurochemistry, 2007
AbstractThe striatum – the largest integrative component of the basal ganglia – harbors a population of neurons that express the enzyme tyrosine hydroxylase (TH), a faithful marker of dopaminergic neurons. The dopaminergic nature of these neurons is further supported by the fact that they express the dopamine (DA) transporter (DAT) and the nuclear ...
Philippe, Huot, André, Parent
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Dopaminergic neurons in the human retina

Journal of Comparative Neurology, 1982
AbstractThe utilization of dopamine in the adult human retina was examined by using high‐affinity uptake, localization, synthesis, and release as neurotransmitter‐specific physiological probes. Autoradiographic and histochemical studies have shown that dopamine‐accumulating and dopamine‐containing cells of the human retina belong to a population of ...
J M, Frederick, M E, Rayborn, A M, Laties, D M, Lam, J G, Hollyfield   +4 more
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Toxicity of semaphorin3A for dopaminergic neurons

Neuroscience Letters, 2005
Semaphorin3A (Sema3A) is known to cause neuronal apoptosis and serves as a chemorepellent factor for axonal growth. In our previous report, we found that Sema3A was up-regulated in the 6-OHDA-injected striatum of rats, suggesting that Sema3A was likely involved in dopaminergic (DA) depletion.
Takao, Yasuhara, Tetsuro, Shingo, Kenichiro, Muraoka, Masahiro, Kameda, Takashi, Agari, Yuan, Wenji, Tomohito, Hishikawa, Toshihiro, Matsui, Yasuyuki, Miyoshi, Toru, Kimura, Cesario V, Borlongan, Isao, Date   +11 more
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Dopaminergic Dependency of Cholinergic Pallidal Neurons

Neuroscience, 2023
We employed the whole-cell patch-clamp method and ChAT-Cre mice to study the electrophysiological attributes of cholinergic neurons in the external globus pallidus. Most neurons were inactive, although approximately 20% displayed spontaneous firing, including burst firing.
Janintzitzic López-Niño, Montserrat Padilla-Orozco, Aidán Ortega, Verónica Alejandra Cáceres-Chávez, Dagoberto Tapia, Antonio Laville, Elvira Galarraga, José Bargas   +7 more
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Dopaminergic neurons for Parkinson's therapy

Nature Biotechnology, 2012
A differentiation protocol guided by developmental principles produces more-authentic dopaminergic neurons for transplantation in patients.
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A Diet for Dopaminergic Neurons?

2009
Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive ...
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