Results 231 to 240 of about 598,888 (295)

Neuropsychiatric and Cognitive Symptom Evolution over the First Decade of Biomarker‐Positive, Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is frequently accompanied by neuropsychiatric symptoms (NPS), including cognitive impairment, which often emerge early and co‐occur. Their long‐term evolution remains incompletely characterized, particularly in biomarker‐positive cohorts.
Izabelle Schoen, Jing Wang, Sharon X. Xie, Chelsea Caspell‐Garcia, Eugenia Mamikonyan, Melanie Stark, Nabila Dahodwala, Andrew D. Siderowf, Roseanne Dobkin, Michele K. York, Daniel Weintraub   +10 more
wiley   +1 more source

Neuroprotective effect of mesenchymal stem cell-derived miR-143-3p on dopaminergic neurons via the TLR3/NF-κB/p53 signaling pathway. [PDF]

Stem Cell Res Ther
Sun J, Wang T, Qiu C, Li T, Wang P, Matveeva T, Boyd T, Tang Q, Xue J, Su L, Seo H, Sun YE, Cheng TL, Schweitzer J, Song B.   +14 more
europepmc   +1 more source

Cerebellar Network Organization in Parkinson's Disease: Functional Connectivity across Motor and Cognitive Circuits

Movement Disorders, EarlyView.
Abstract Background The cerebellum is increasingly recognized as a key contributor to cognitive reserve and network organization in Parkinson's disease (PD). However, the relationship of cerebello‐cortical and cerebello‐basal ganglia connectivity with cognitive status and nigrostriatal integrity remains incompletely understood.
Chi‐Ying R. Lin, Thamires N.C. Magalhães, Shayla S. Yonce, Ihika Rampalli, Rory Mahabir, Jessica A. Bernard, and the Parkinson's Precision Medicine Initiative   +6 more
wiley   +1 more source

Parkin regulates NLRP3 degradation through chaperone-mediated autophagy to suppress PANoptosis and protect dopaminergic neurons in Parkinson's disease. [PDF]

J Neuroinflammation
Zheng D, Zhang H, Xie A, Xiao H, Guan D, Xie Z, Luo J, Cao J, Lin T, Xing L, Xia T, Zou F, Chen J.   +12 more
europepmc   +1 more source

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source

α-Lipoic acid suppresses p53 by preventing annexin A2 degradation to protect dopaminergic neurons in a Parkinson's disease model. [PDF]

Front Neurosci
Liu Y, Sun W.
europepmc   +1 more source

Remimazolam Ameliorates Autistic-Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD. [PDF]

Adv Sci (Weinh)
Zhang Y, Lin J, Tong C, Fu X, Shan M, Huang Y, Zhang K, Zheng J.   +7 more
europepmc   +1 more source

Neuropeptide S Protects Dopaminergic Neurons in a Paraquat-Induced Parkinson's Model Using SH-SY5Y Cells. [PDF]

Mol Neurobiol
Koçancı FG, Bülbül M, Akçalı İ, Kipmen-Korgun D, Çubukçu E, Aslan MA, Öztüzün A, Akkan SS, Çeker T, Agar A.   +9 more
europepmc   +1 more source

Severe Parkinson's Disease Linked to SNCA Locus Triplication Is Associated with Expression Changes in Platelets: A Case Report

Movement Disorders, EarlyView.
Susanna Jiménez‐Román, David Adamuz, Jorge Mena, Abril Tuset, Mar Mallo, Alex Menendez, Daniela Samaniego, Lourdes Ispierto, Dolores Vilas, Pau Pastor, Katrin Beyer   +10 more
wiley   +1 more source

Subtype-specific roles of nigrostriatal dopaminergic neurons in motor and associative learning. [PDF]

Ageing Neurodegener Dis
Habib A, Riccobono G, Tian L, Basu D, Sun L, Chang L, Martinez Smith VM, Wang L, Le W, Cai H.   +9 more
europepmc   +1 more source