Results 251 to 260 of about 598,888 (295)
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Aberrant accumulation of serotonin in dopaminergic neurons
Neuroscience Letters, 2006Gene targeting approaches greatly facilitate insight into the functioning of monoamine transporters, the targets of potent antidepressants. The serotonin transporter (5-HTT) is the molecular target of a large number of antidepressants. To assess the clearance of serotonin (5-HT) in the absence of the 5-HTT, we have generated double knockout mice ...
Rainald, Mössner +4 more
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Dopaminergic Neurons in the Cat Retina
Optometry and Vision Science, 1988ABSTRACT Dopaminergic neurons have been directly visualized in the flat mount cat retina with an immunohistochemical technique that uses antisera directed to the enzyme tyrosine hydroxylase. In a previous study, three specific neuronal populations‐amacrine cells, displaced amacrine (DA) cells, and interplexiform (IP) cells‐were ...
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Tuberoinfundibular neurons: Dopaminergic and norepinephrinergic sensitivity
Brain Research, 1975The techniques of microelectrophoresis and antidromic identification have been utilized in the female rat anesthetized with urethane to localize the tuberoinfundibular neurons and to determine their pharmacological sensitivity to dopamine (DA), norepinephrine (NE) and glutamate (GLUT).
R L, Moss, M, Kelly, P, Riskind
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How to make a mesodiencephalic dopaminergic neuron
Nature Reviews Neuroscience, 2007Dopaminergic neurons located in the ventral mesodiencephalon are essential for the control of voluntary movement and the regulation of emotion, and are severely affected in neurodegenerative diseases such as Parkinson's disease. Recent advances in molecular biology and mouse genetics have helped to unravel the mechanisms involved in the development of ...
Marten P, Smidt, J Peter H, Burbach
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The organization of dopaminergic and non-dopaminergic mesencephalo-cortical neurons in the rat
Brain Research, 1982The dopamine containing mesencephalo-cortical pathway was studied in the rat by means of a combined retrograde fluorescent tracing and catecholamine histofluorescence technique. After large injections of the fluorescent retrograde tracer, Evans blue, into the frontal cortex, many neural somata of the ventral midbrain tegmentum were retrogradely labeled;
Albanese, Alberto, Bentivoglio, M.
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Development of dopaminergic neurons in the mammalian brain
Cellular and Molecular Life Sciences CMLS, 2006Dopaminergic neurons in the mammalian brain have received substantial attention in the past given their fundamental role in several body functions and behaviours. The largest dopaminergic population is found in two nuclei of the ventral midbrain. Cells of the substantia nigra pars compacta are involved in the control of voluntary movements and postural
N, Prakash, W, Wurst
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Dopaminergic Regulation of Septohippocampal Cholinergic Neurons
Journal of Neurochemistry, 1994Abstract: The extent to which acetylcholine (ACh) release in the hippocampus is regulated by dopaminergic mechanisms was assessed using in vivo microdialysis in freely moving rats. Systemic administration of the dopamine (DA) receptor agonist apomorphine (1.0 mg/kg) or the specific D1 agonist CY 208–243 (1.0 mg/kg) increased microdialysate ...
J C, Day, H C, Fibiger
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Burst firing in midbrain dopaminergic neurons
Brain Research Reviews, 1997Midbrain dopaminergic (DA) neurons fire bursts of activity in response to sensory stimuli, including those associated with primary reward. They are therefore conditional bursters - the bursts conveying, amongst other things, motivationally relevant information to the forebrain. In the forebrain, bursts give rise to a supra-additive release of dopamine,
P G, Overton, D, Clark
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Dopaminergic neurons in sympathetic ganglia of the dog
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1982Abstract A study has been made of the catecholamine content of various canine sympathetic ganglia. The data have been related to the anatomical location of ganglion cells supplying the kidney and hindpaw. Retrograde transport of horseradish peroxidase from filaments of the renal nerve labelled cell bodies in the ipsilateral renal and ...
C, Bell, E M, McLachlan
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Genetic control of dopaminergic neuron differentiation
Trends in Neurosciences, 2005The mesencephalic dopaminergic (mesDA) system controls movement and emotional behaviour, and its degeneration causes Parkinson's disease and other psychiatric disorders. Recent findings are leading to better understanding of the genetic control of generation and functioning of the mesDA system.
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