Aberrant Beta‐Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease
Abstract Background Freezing of gait (FOG) is a debilitating motor symptom observed in the advanced stages of Parkinson's disease (PD), characterized by an abrupt inability to initiate or continue forward walking. Whole‐brain functional connectivity analysis has shown promise in elucidating the underlying pathophysiology and identifying potential ...
Yanqiu Tian +3 more
wiley +1 more source
Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons. [PDF]
Cai H, Gerfen C.
europepmc +1 more source
Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease
Abstract Background Aperiodic spectral broadband power has been described recently as reflecting Parkinson's disease (PD) severity. It has therefore become an increasing focus of research interest in the context of the new adaptive deep brain stimulation (DBS) approach.
Martin Lamoš +6 more
wiley +1 more source
Fiber Distribution and Myelination of Dopaminergic Neurons in the Medial Forebrain Bundle of a Rodent Depression Model. [PDF]
Duan Z +4 more
europepmc +1 more source
Abstract Background Serum neurofilament light chain (NfL) levels, a marker of axonal damage, are generally elevated in neurodegenerative conditions, but results in idiopathic Parkinson's disease (iPD) have been inconsistent. The p.A53T SNCA mutation usually leads to a severe form of PD.
Nikolaos Papagiannakis +213 more
wiley +1 more source
Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Medial Amygdala. [PDF]
Armbruster D, Mueller T, Driever W.
europepmc +1 more source
When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel +6 more
wiley +1 more source
GDNF receptor GFRα1 is necessary for the maintenance of dopaminergic neurons in the adult substantia nigra. [PDF]
Carrier-Ruiz A +3 more
europepmc +1 more source
Unraveling the mystery: How autophagy deficiency in dopaminergic neurons drives human Parkinson's disease. [PDF]
Noda S, Hattori N.
europepmc +1 more source

