Results 191 to 200 of about 598,888 (295)

Long-term inhibition of lysosomal glucocerebrosidase activity promotes GPX4 stability and inhibits ferroptosis in dopaminergic neurons. [PDF]

Cell Death Dis
Bonte MA, Gouel F, Jonneaux A, Belarbi K, Devos D, Devedjian JC.   +5 more
europepmc   +1 more source

Lower Urinary Tract Symptoms as Diagnostic Clues in Parkinsonism: A Practical Framework for Neurologists

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Lower urinary tract symptoms (LUTS) are among the most prevalent nonmotor complaints across the parkinsonian spectrum, yet they remain underutilized as diagnostic and management signals in neurology practice. Although prior reviews have characterized disease‐specific patterns of urinary dysfunction, and recent guidelines address ...
Saar Anis, Omer Anis, Abhishek Lenka, Junaid H. Siddiqui   +3 more
wiley   +1 more source

Expression of Axonal Transport Proteins in Dopaminergic Neurons of the Substantia Nigra in Mouse Models of Preclinical and Clinical Stages of Parkinson's Disease. [PDF]

Int J Mol Sci
Kolacheva A, Troshev D, Antonova A, Pavlova E, Bogdanov V, Kalashnikova V, Popova A, Shchepina M, Ugrumov M.   +8 more
europepmc   +1 more source

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. Objectives To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to identify clinical variables associated with therapeutic response ...
Daniel Weiss, Idil Cebi, Marion Schütt, Imma Fischer, Lukas Pavelka, Pierre Kolber, Monika Pötter‐Nerger, Wolfgang Hamel, Andrea A. Kühn, Christian J. Hartmann, Kai Bötzel, Thomas Köglsperger, Michael T. Barbe, Zacharias Kohl, Steffen Paschen, Markus A. Hobert, Sergiu Groppa, Tobias Warnecke, Inga Claus, Rejko Krüger, Alireza Gharabaghi, For the Multicenter STN+SNr Study Group, Christian Stallinger, Frank Hertel, Daniel Kroneberg, Carsten Buhmann, Alessandro Gulberti, Beate Schönewald, Verena Zentsch, Verle Visser‐Vandewalle   +29 more
wiley   +1 more source

Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons. [PDF]

Front Cell Neurosci
Seddon J, Kramer PF.
europepmc   +1 more source

JAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?

Movement Disorders Clinical Practice, EarlyView.
Abstract Background JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...
Elena Ardila Jurado, Koustubh Bavdhankar, Divyani Garg, Francesca Magrinelli, Huw R. Morris, Kailash P. Bhatia   +5 more
wiley   +1 more source

Sodium Propionate Protects Dopaminergic Neurons Against Mitochondrial Toxin-Induced Oxidative Stress In Vitro. [PDF]

Int J Mol Sci
Adetuyi OA, Wimalasena K.
europepmc   +1 more source

Sleep‐Autonomic Interactions in Parkinson's Disease and Multiple System Atrophy: A Comparative Study Using Structural Equation Modeling

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) and multiple system atrophy (MSA) are α‐synucleinopathies with overlapping autonomic and sleep dysfunction, but distinct trajectories. Objectives This study compared sleep and autonomic profiles in PD and MSA and elucidated disease‐specific associations using structural equation modeling (SEM).
Bora Jin, Yoonkyung Lee, Seungho Lee, Byeol‐A Yoon, Young Jin Jeong, Sang‐Myung Cheon   +5 more
wiley   +1 more source

Continuous Subcutaneous Apomorphine as a Temporary Bridging Therapy for Dopamine Dysregulation Syndrome in Patients with Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dopamine dysregulation syndrome (DDS) is a challenging complication of dopaminergic therapy in Parkinson's disease and can persist despite subthalamic deep brain stimulation (STN‐DBS). We evaluated a temporary bridging concept in which oral dopaminergic medication was replaced by continuous subcutaneous apomorphine infusion while ...
Tobias Binder, Johannes Hartig, Lennart Sitzmann, Chi Wang Ip, Philipp Capetian, Florian Lange, Martin Reich, Christine Daniels, Jens Volkmann   +8 more
wiley   +1 more source

In vitro and in vivo rescue of dopaminergic neurons in Parkinson's disease models after Parkin gene therapy. [PDF]

Gene Ther
Hioki T, Nishimura M, Sun X, Jacobo SM, Nakayama M, Nishihara M, Tohyama K, Liu PT, Okai T, Tanaka M, Proetzel G.   +10 more
europepmc   +1 more source