Results 181 to 190 of about 194,049 (307)

Microglial low-affinity FcγR mediates the phagocytic elimination of dopaminergic neurons in Parkinson's disease degeneration. [PDF]

NPJ Parkinsons Dis
Casanova PV, Freitag-Berenguel I, Saavedra-López E, Usandizaga-Estarloa M, Ríos-Cuadrado C, Martínez-Remedios P, Giménez-Montes C, Clinton E, Roig-Martínez M, Cribaro GP, Barcia C.   +10 more
europepmc   +1 more source

Genetic and Pathological Testing Attitudes for Parkinson's Disease in At‐Risk Relatives

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. α‐synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals.
Tal Weil, Anat Mirelman, Roy N. Alcalay, Nurit Omer, Penina Ponger, Avner Thaler   +5 more
wiley   +1 more source

Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons. [PDF]

Neuropsychopharmacology
Huang Y, Michalski C, Zhou Y, Xu C, Niu W, Lucido MJ, Wang J, Feng Y, Miller AH, Wen Z.   +9 more
europepmc   +1 more source

Quantitative Assessment of Visible Nigrosome‐1 in Patients with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The nigrosome‐1 (N1) sign on susceptibility‐weighted imaging (SWI) typically disappears in Parkinson's disease (PD), though some patients can show uni−/bilaterally preserved N1. Objective Investigating whether visible nigrosomes in PD patients differ from those of healthy subjects (HC). Methods Forty‐eight PD and 35 HC underwent 3 T‐
Maria Eugenia Caligiuri, Ilaria Chimento, Marida De Maria, Emma Biondetti, Jolanda Buonocore, Valerio Riccardo Aquila, Maria Celeste Bonacci, Emanuele Tinelli, Umberto Sabatini, Aldo Quattrone, Andrea Quattrone   +10 more
wiley   +1 more source

Remimazolam Ameliorates Autistic-Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD. [PDF]

Adv Sci (Weinh)
Zhang Y, Lin J, Tong C, Fu X, Shan M, Huang Y, Zhang K, Zheng J.   +7 more
europepmc   +1 more source

Subthalamic Nucleus Deep Brain Stimulation Improves Kinetic Tremor in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Although resting tremor is a characteristic feature of Parkinson's disease (PD), many patients also suffer from action tremor. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in reducing motor symptoms. However, it is unclear to what extent STN‐DBS improves action tremor in PD, particularly kinetic tremor.
Iwan Grooters, Bart E.K.S. Swinnen, Yarit Wiggerts, Maarten Bot, Pepijn van den Munckhof, P. Rick Schuurman, Martijn Beudel, Rob M.A. de Bie, Arthur W.G. Buijink   +8 more
wiley   +1 more source

Neuropeptide S Protects Dopaminergic Neurons in a Paraquat-Induced Parkinson's Model Using SH-SY5Y Cells. [PDF]

Mol Neurobiol
Koçancı FG, Bülbül M, Akçalı İ, Kipmen-Korgun D, Çubukçu E, Aslan MA, Öztüzün A, Akkan SS, Çeker T, Agar A.   +9 more
europepmc   +1 more source

A new glucocerebrosidase chaperone reduces α-synuclein and glycolipid levels in iPSC-derived dopaminergic neurons from patients with gaucher disease and parkinsonism [PDF]

, 2016
et al,, Fujiwara, Hideji, Ory, Daniel S, Sidhu, Rohini   +3 more
core   +1 more source

Electrochemical measurements at human iPSC-derived FOXA2 dopaminergic neurons suggest a role for partial release in presynaptic plasticity. [PDF]

QRB Discov
Gu C, Lork A, Majdi S, Rabasco S, Peng H, Ni A, Ernst C, Ewing AG.   +7 more
europepmc   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source