Results 181 to 190 of about 598,888 (295)

Temporal interference stimulation rescues dopaminergic neurons in the substantia nigra of MPTP-induced Parkinson's disease mice via inhibition of lipid peroxidation. [PDF]

J Transl Med
Sun L, Qin H, Zhou B, Hao Y, Ding Z, He Z, Zheng Y, Zhu Y.   +7 more
europepmc   +1 more source

Acute and Chronic Local Field Potential Recordings in Dystonia—A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Dystonia is a hyperkinetic movement disorder increasingly conceptualized as a disorder of distributed network dysfunction involving the basal ganglia, cortex and cerebellum. Local field potentials (LFPs) recorded from deep brain stimulation (DBS) electrodes provide a unique opportunity to characterize the electrophysiological signatures ...
Jack Horan, Eoghan Donlon, Aoibheann Gill, Rosalyn Moran, Conor Fearon, Richard A. Walsh, Catherine Moran   +6 more
wiley   +1 more source

The human LRRK2-R1441G mutation drives age-dependent oxidative stress and mitochondrial dysfunction in dopaminergic neurons. [PDF]

Mol Neurodegener
Chen Y, Zhi L, Cui S, Wang H, Zeng C, Zhang H.   +5 more
europepmc   +1 more source

Machine Learning Prediction of Hoehn and Yahr Scores at 5‐Years Post‐123I‐Ioflupane SPECT Imaging in a Real‐World Parkinson's Disease Dataset

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) progression is highly heterogeneous, complicating clinical management and prognostication. While machine learning models have been developed using research datasets such as Parkinson's Precision Medicine Initiative (PPMI) and Parkinson's Disease Biomarkers Program (PDBP), their clinical translatability is ...
Xuehua Ye, Mette Niemann Johansen, Balazs Laczi, Mads Peter Horndrup, Michael Zaucha Sørensen, Rasmus Vestergård Madsen, Jan Wolber, Markus Lonsdale, Annemette Lokkegaard, Renee Miller   +9 more
wiley   +1 more source

Neuromodulatory control of energy reserves in dopaminergic neurons. [PDF]

Proc Natl Acad Sci U S A
Pulido C, Gentry MS, Ryan TA.
europepmc   +1 more source

Modeling Parkinson's pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneity. [PDF]

Sci Adv
Mahul-Mellier AL, van den Heuvel L, Teixeira M, Boussouf MLN, Oudinot G, Thonet A, Speri D, Jasiqi Y, Ulrich C, Sheta R, Idi W, Croisier M, Clerc-Rosset S, Blanc J, Knott G, Oueslati A, Lashuel HA.   +16 more
europepmc   +1 more source

The Incidence of Sensorineural Hearing Loss Diagnoses in People with and without Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) and sensorineural hearing loss (SNHL) are both prevalent conditions among older adults. Although increasing number of studies have investigated SNHL as a risk factor for PD, it is not well known how diagnosed PD affects the likelihood of SNHL diagnosis.
Kaisa Hokkinen, Aarno Dietz, Pasi Lampela, Sirpa Hartikainen, Anna‐Maija Tolppanen   +4 more
wiley   +1 more source

Simvastatin Protects the Dopaminergic Neurons from MPTP-Mediated Injury by Inducing BDNF via PPARα Activation. [PDF]

Biomol Ther (Seoul)
Bohara G, Rimal N, Khanal S, Park PH, Choi DY.   +4 more
europepmc   +1 more source

Exercise and Motor Complications in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Levodopa remains the most effective pharmacological treatment for Parkinson's disease (PD), but long‐term use commonly leads to motor complications such as levodopa‐induced dyskinesia (LID) and motor fluctuations, significantly contributing to disability. Exercise is well‐established for improving motor and non‐motor symptoms in PD;
Priscila Nóbrega‐Sousa, Lucas H.C.C. Santos, Jane Alty, Peter Humburg, Kim Delbaere, Paulo H.S. Pelicioni   +5 more
wiley   +1 more source

Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture. [PDF]

Mol Psychiatry
Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley L, Deleidi M.   +5 more
europepmc   +1 more source