Results 171 to 180 of about 122,423 (305)

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Evaluation of a commercial AI-assisted cell counting software for dopaminergic neurons across species. [PDF]

PLoS One
Kunugitani K, Sawamura M, Taguchi T, Hirato T, Uemura N, Ayaki T, Nakanishi E, Yamakado H, Ishimoto T, Onoe H, Isa T, Matsumoto R, Takahashi R.   +12 more
europepmc   +1 more source

Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia‐induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism. Purpose To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with ...
Kun Wang, Jiahe Wang, Ziyu Diao, Xin Tan, Shijun Qiu, Jie An   +5 more
wiley   +1 more source

Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons. [PDF]

Front Cell Neurosci
Seddon J, Kramer PF.
europepmc   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons. [PDF]

Stem Cell Res Ther
Chanoumidou K, Zota I, Papadopoulou MA, Konstantinou C, Tsimpolis A, Tsagliotis E, Tziortziou M, Ntarntani K, Grünewald A, Lavigne MD, Gravanis A, Charalampopoulos I.   +11 more
europepmc   +1 more source

Genetic and Pathological Testing Attitudes for Parkinson's Disease in At‐Risk Relatives

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. α‐synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals.
Tal Weil, Anat Mirelman, Roy N. Alcalay, Nurit Omer, Penina Ponger, Avner Thaler   +5 more
wiley   +1 more source

Pleiotrophin over-expression rescues dopaminergic neurons in parkinsonian rats

Background: Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients.
Chertoff, Mariela, Murer, Mario G., Taravini, Irene R. E., Courty, José, Pitossi, Fernando J., Cafferata, Eduardo G., Gershanik, Oscar S.   +6 more
core  

Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson's disease vascular alterations. [PDF]

Commun Eng
Alim A, Baek Y, Lee M, Paek J.
europepmc   +1 more source

Irisin as a Neuroprotective Agent in Parkinson's Disease: The Role of Physical Exercise in Modulating Dopaminergic Neurons. [PDF]

Pharmacy (Basel)
de Brito-Neto JG, Morais PLG, Cavalcanti JRLP, Pinheiro FI, Guzen FP, Cobucci RN.   +5 more
europepmc   +1 more source