Results 51 to 60 of about 199,386 (303)

Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. [PDF]

, 2011
Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the survival and maintenance of the midbrain dopaminergic (DA-ergic) neurons.
Ahmadiantehrani, S, Barak, S, Kharazia, V, Ron, D   +3 more
core   +3 more sources

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease

Neurobiology of Disease, 2010
Parkinson's disease has been found to be caused by both, genetic and environmental factors. Despite the diversity of causes involved, a convergent pathogenic mechanism might underlie the special vulnerability of dopaminergic neurons in different forms of
Florian Bayersdorfer, Aaron Voigt, Stephan Schneuwly, José A. Botella   +3 more
doaj   +1 more source

The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons

Cells, 2022
Pregabalin is widely used as a treatment for multiple neurological disorders; however, it has been reported to have the potential for misuse. Due to a lack of safety studies in pregnancy, pregabalin is considered the last treatment option for various ...
Walaa F. Alsanie, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A. Alkhatabi, Raed I. Felimban, Sherin Abdelrahman, Charlotte A. E. Hauser, Adeel G. Chaudhary, Abdulhakeem S. Alamri, Bassem M. Raafat, Abdulwahab Alamri, Sirajudheen Anwar, Khaled A. Alswat, Yusuf S. Althobaiti, Yousif A. Asiri   +15 more
doaj   +1 more source

Deficient reinforcement learning in medial frontal cortex as a model of dopamine-related motivational deficits in ADHD [PDF]

, 2013
A
Barke, Edmund, Silvetti, Massimo, Verguts, Tom, Wiersema, Roeljan   +3 more
core   +2 more sources

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Sequential loss of LC noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration

Frontiers in Pharmacology, 2012
Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson’s disease (PD) and the LC exhibits neuropathological changes early in the disease process.
Patricia eSzot, Patricia eSzot, Allyn eFranklin, Carl eSikkema, Charles W Wilkinson, Charles W Wilkinson, Murray A Raskind, Murray A Raskind   +7 more
doaj   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source