Results 1 to 10 of about 4,818 (161)

Comparative efficacy of doripenem versus meropenem for hospital-acquired and ventilator-associated pneumonia

Journal of Microbiology, Immunology and Infection, 2019
Background: Doripenem shows good in vitro activity against common nosocomial pathogens, such as extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Wang-Da Liu, Ming-Chieh Shih, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng   +4 more
doaj   +3 more sources

Doripenem [PDF]

Clinical Infectious Diseases, 2009
Carbapenems play a significant role in the current antibiotic armamentarium. Doripenem is the newest carbapenem to be commercially released. Its antimicrobial spectrum more closely resembles those of meropenem and imipenem than that of ertapenem. Thus, it has significant in vitro activity against streptococci, methicillin-susceptible staphylococci ...
Paterson, David L., DePestel, Daryl D.
openaire   +6 more sources

Doripenem. Un nuevo Carbapenem

Revista Electrónica de AnestesiaR, 2010
En el año 2007 la FDA y posteriormente la EMEA aprobaron el uso de este nuevo ß-lactámico del grupo de los Carbapenem. El objetivo de esta revisión es comunicar de forma breve y sencilla las características de este nuevo antibiótico, relacionado con los ...
Enrique Alday
doaj   +2 more sources

Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations

Antibiotics, 2022
The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy Chinese subjects and evaluate the optimal dosage regimens of doripenem.
Yu Wang, Xiaofen Liu, Kun Li, Yaxin Fan, Jicheng Yu, Hailan Wu, Yi Li, Xiaojie Wu, Beining Guo, Xin Li, Jiali Hu, Jufang Wu, Guoying Cao, Jing Zhang   +13 more
doaj   +1 more source

Carbapenem resistance gene crisis in A. baumannii: a computational analysis

BMC Microbiology, 2022
Acinetobacter baumannii (A. baumannii) is one of the members of ESKAPE bacteria which is considered multidrug resistant globally. The objective of this study is to determine the protein docking of different antibiotic resistance gene (ARGs) in A ...
Nureen Zahra, Basit Zeshan, Musarat Ishaq   +2 more
doaj   +1 more source

Anti-Mutant Efficacy of Combination Therapy with Doripenem and Levofloxacin: In Vitro Model Studies with Pseudomonas Aeruginosa

Антибиотики и Химиотерапия, 2021
Relevance. The tendency to a decrease in sensitivity of bacterial agents to old antibiotics, as well as the slowdown in creation of new medications, dictate the need to develop effective approaches to combat bacterial resistance.Aim.
M. V. Golikova, E. N. Strukova, K. N. Alieva, A. V. Filimonova, Yu. A. Portnoy, A. A. Firsov   +5 more
doaj   +1 more source

Fingolimod Promotes Antibacterial Effect of Doripenem against Carbapenem-Resistant Escherichia coli

Antibiotics, 2022
The aim of this study was to determine whether fingolimod could synergize the antibacterial activity of doripenem against carbapenem-resistant Escherichia coli (CREC) and its potential as an antibiotic adjuvant for doripenem. The E.
Hye-Won Jin, Hye-Rim Kim, Yong-Bin Eom
doaj   +1 more source

Pharmacodynamics of Doripenem Alone and in Combination with Relebactam in an In Vitro Hollow-Fiber Dynamic Model: Emergence of Resistance of Carbapenemase-Producing Klebsiella pneumoniae and the Inoculum Effect

Antibiotics, 2023
The emergence of bacteria resistant to beta-lactam/beta-lactamase inhibitor combinations is insufficiently studied, wherein the role of the inoculum effect (IE) in decreased efficacy is unclear.
Elena N. Strukova, Maria V. Golikova, Svetlana A. Dovzhenko, Mikhail B. Kobrin, Stephen H. Zinner   +4 more
doaj   +1 more source

Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: The antimicrobial activity of doripenem in comparison of imipenem, meropenem and ertapenem among Pseudomonas aeruginosa isolated from burn and Cystic Fibrosis (CF) patients were determined.
Reza Bigverdi, Mona Ghazi, Mostafa Davodi, Tahereh Pirzadeh, Morteza Ghojazadeh, Mohammad Hossein Soroush, Mohammad Reza Nahaei, Mohammad Ahangarzadeh Rezaee, Zoya Hojabri, Omid Pajand, Mohammad Aghazadeh   +10 more
doaj   +1 more source

PREPARATION OF ANTIBACTERIAL BENTONITE β LACTAM ANTIBIOTIC COMPOSITE

EQA, 2018
The adsorption of Doripenem (beta-lactam antibiotic belonging to the subgroup carbapenem) from aqueous solution using bentonite as the adsorbent was studied at various pH of the solution. The doripenem loaded in bentonite which called doripenem-bentonite
Gladdy Waworuntu, Gisela Anke Hanelin, Lukius Denny Wiyanto, Livy Laysandra, Felycia Edi Soetaredjo   +4 more
doaj   +1 more source