Results 41 to 50 of about 5,549 (198)

Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin in Pseudomonas aeruginosa

Canadian Journal of Infectious Diseases and Medical Microbiology, 2009
BACKGROUND: With a limited number of available antimicrobial agents to treat Pseudomonas aeruginosa infections, the prevention of emergence of antimicrobial resistance and its subsequent spread is critical.
George G Zhanel, Vibhu Vishisht, Ed Tam, Daryl J Hoban, James A Karlowsky   +4 more
doaj   +1 more source

Intereactions between doripenem and clavulanate — Application of minimal inhibitory concentration analysis and cytometry flow for bactericidal studies

Electronic Journal of Biotechnology, 2018
Background: In view of the current low efficacy of bacterial infection treatment the common trend towards searching for antibiotic systems exhibiting synergistic action is well justified.
Katarzyna Ciemniak, Judyta Cielecka-Piontek, Daria Szymanowska, Gabriela Wiergowska   +3 more
doaj   +1 more source

Gut Microbiota as Well as Metabolomes of Wistar Rats Recover within Two Weeks after Doripenem Antibiotic Treatment

Microorganisms, 2023
An understanding of the changes in gut microbiome composition and its associated metabolic functions is important to assess the potential implications thereof on host health.
Aishwarya Murali, Franziska Maria Zickgraf, Philipp Ternes, Varun Giri, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk Weyer, Shana J. Sturla, Ivonne M. G. M. Rietjens, Bennard van Ravenzwaay   +12 more
doaj   +1 more source

Bench‐Stable Boryl Thianthrenium Dication Enables Aziridinyl Boronate Synthesis via Metal‐Free Late‐Stage Aziridination with Diverse Nitrogen Nucleophiles

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A bench‐stable boryl thianthrenium dication is synthesized via thianthrenation of vinyl MIDA boronate. This novel dication enables metal‐free, chemo‐, and diastereoselective late‐stage aziridination with diverse nitrogen nucleophiles. The strategic significance is further showcased by one‐pot electrochemical and asymmetric protocols and versatile ...
Veerabhadra R. Vulupala, Disni Gunasekera, Nagarjun R. Mallampudi, Ramy Yousef, Yusif I. Gyasi, Gopal R. Ramidi, Ifeoluwa Adedotun, Shiqing Xu   +7 more
wiley   +2 more sources

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

DORIPENEM IN THERAPY OF PATIENTS WITH COMPLICATED UROLOGIC INFECTION

Медицинский совет, 2016
Currently, one of the most common issues in medicine is antibiotics resistance. This relates to nosocomial and to communityacquired infections. This problem is common for economically developed countries of the whole world and in its significance must be
G. G. KRIVOBORODOV, E. I. TUR
doaj   +1 more source

Efficacy of Intravenous Infusion of Doripenem [PDF]

Clinical Infectious Diseases, 2009
Initial treatment of nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP), is usually empirical. The use of a broad-spectrum antibiotic regimen to treat NP-VAP that is active against suspected multidrug-resistant pathogens maximizes the likelihood of a favorable outcome.
openaire   +2 more sources

Perioperative Prophylaxis in Pediatric Solid Organ Transplantation: A Baseline Stewardship Audit Using Routine Electronic Data

Transplant Infectious Disease, EarlyView.
Using routine electronic data from 164 pediatric transplants, we created reproducible stewardship measures of perioperative prophylaxis practice across transplant populations and protocol pathways. Starting prophylaxis was reliable, but continuation beyond intended stop targets—especially in abdominal transplantation—identified the clearest target for ...
Charles B. Foster, Kaitlyn Rivard, Venkatraman A. Arakoni, Blanca E. Gonzalez   +3 more
wiley   +1 more source

Overview and Insights into Carbapenem Allergy

Pharmacy, 2019
Understanding antibiotic allergies and the risk of cross-sensitivity between and within antibiotic classes can have a substantial impact on patient care.
Yuman Lee, Nicole Bradley
doaj   +1 more source

Focused Update to International Consensus Recommendations for the Use of Prolonged‐Infusion Beta‐Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 9, September 2026.
ABSTRACT In 2023, international consensus recommendations suggested the use of prolonged‐infusion beta‐lactam antibiotics over short‐infusion dosing in severely ill adult patients to improve mortality or clinical cure, although the certainty of evidence was very low. With the availability of several new randomized controlled trials (RCTs), this focused
Lisa T. Hong, Alireza FakhriRavari, Marta Ulldemolins, Jason A. Roberts, Robert A. Bonomo, Marc H. Scheetz, on behalf of the Prolonged‐Infusion Beta‐Lactam Consensus Panel, Jacinda C. Abdul‐Mutakabbir, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Kevin J. Downes, Alireza FakhriRavari, Mark Gilchrist, Lisa T. Hong, Jason A. Roberts, Marc H. Scheetz, Thomas Tängdén, Marta Ulldemolins, David C. Young   +19 more
wiley   +1 more source