Results 61 to 70 of about 6,860 (236)

Ceftazidime-avibactam Versus Doripenem for the Treatment of Complicated Urinary Tract Infections, Including Acute Pyelonephritis: RECAPTURE, a Phase 3 Randomized Trial Program

Clinical Infectious Diseases, 2016
There is an urgent need for new strategies to reduce carbapenem consumption. Ceftazidime-avibactam was highly effective for empiric treatment of complicated urinary tract infection, including in patients with ceftazidime-nonsusceptible pathogens, and may
F. Wagenlehner, J. Sobel, P. Newell, J. Armstrong, Xiangning Huang, G. Stone, Katrina Yates, L. Gasink   +7 more
semanticscholar   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

Mortality after broad‐ versus narrow‐spectrum antibiotic treatment for patients with nursing and healthcare‐associated pneumonia: A nationwide retrospective cohort study

Journal of Hospital Medicine, Volume 21, Issue 5, Page 477-486, May 2026.
Visual Abstract Abstract Background Nursing and healthcare‐associated pneumonia (NHCAP) is defined as pneumonia occurring in individuals with frequent healthcare contact, such as residents of care facilities or patients with impaired activities of daily living.
Jumpei Taniguchi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga   +4 more
wiley   +1 more source

Population pharmacokinetic analysis of doripenem for Japanese patients in intensive care unit

Scientific Reports, 2020
We aimed to construct a novel population pharmacokinetics (PPK) model of doripenem (DRPM) for Japanese patients in intensive care unit, incorporating the clearance of DRPM by continuous renal replacement therapy (CRRT).
Ko Nonoshita, Yosuke Suzuki, Ryota Tanaka, Tetsuya Kaneko, Y. Ohchi, Y. Sato, Norihisa Yasuda, K. Goto, T. Kitano, H. Itoh   +9 more
semanticscholar   +1 more source

THE RADIOLYTIC STUDIES OF DORIPENEM MONOHYDRATE IN THE SOLID STATE

, 2018
The influence of ionising radiation on physicochemical properties of doripenem in solid state was studied. No changes for doripenem irradiated with a dose of 25 kGy, required to attain sterility, was observed by FT-IR and chromatographic methods ...
Bednarski, Waldemar, Miklaszewski, Andrzej, Kilińska, Karolina, Piontek, Judyta C., Zalewski, Przemysław, Skibiński, Robert, Szymanowska, Daria   +6 more
core   +1 more source

Efficacy of Intravenous Infusion of Doripenem [PDF]

Clinical Infectious Diseases, 2009
Initial treatment of nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP), is usually empirical. The use of a broad-spectrum antibiotic regimen to treat NP-VAP that is active against suspected multidrug-resistant pathogens maximizes the likelihood of a favorable outcome.
openaire   +2 more sources

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

Scientific Reports, 2017
Combination therapy is deployed for the treatment of multidrug-resistant Acinetobacter baumannii, as it can rapidly develop resistance to current antibiotics. This is the first study to investigate the synergistic effect of colistin/doripenem combination
M. Maifiah, D. Creek, R. Nation, A. Forrest, Brian T. Tsuji, T. Velkov, J. Li   +6 more
semanticscholar   +1 more source

Influence of Continuous Venovenous Hemofiltration and Continuous Venovenous Hemodiafiltration on the Disposition of Doripenem

, 2011
The pharmacokinetics, safety, and tolerability of a single 1-hour, 500-mg intravenous infusion of doripenem were assessed in dialysis-dependent subjects with stage 5 chronic kidney disease undergoing continuous renal replacement therapy (CRRT) via 12 ...
Cirillo, Iolanda, Iolanda Cirillo, Matzke, Gary R., Rebecca Redman, Vaccaro, Nicole, Dainius Balis, Balis, Dainius, Redman, Rebecca, Nicole Vaccaro, Gary R. Matzke   +9 more
core   +1 more source

Epidemiology, Management, and Alarmingly High Mortality of Burn Patients: A Retrospective Analysis From a Resource‐Limited Tertiary Centre in Syria

International Wound Journal, Volume 23, Issue 4, April 2026.
ABSTRACT Burn injuries pose a significant challenge in resource‐limited settings, particularly during humanitarian crises. This study examines the epidemiology, management, and outcomes of burn patients at a tertiary hospital in Damascus, Syria, from 2021 to 2024.
Lorieh Domat, Adel Azar, Ahmad Alkheder, Diana Mohammad, Jean Domat, Hanady Zwaraa, Rawnak Almidani   +6 more
wiley   +1 more source

Highly sensitive cadmium sulphide quantum dots as a fluorescent probe for estimation of doripenem in real human plasma: application to pharmacokinetic study

RSC Advances, 2020
Thioglycolic acid-capped cadmium sulphide quantum dots (TGA-CdS QDs) have been synthesized and utilized as a fluorescent probe for the estimation of doripenem (DOR).
Marwa F. B. Ali, Baher I. Salman, S. Hussein, Mostafa A. Marzouq   +3 more
semanticscholar   +1 more source