Results 51 to 60 of about 6,860 (236)

Carbapenem-Only Combination Therapy against Multi-Drug Resistant Pseudomonas aeruginosa: Assessment of In Vitro and In Vivo Efficacy and Mode of Action

Antibiotics, 2022
The aim of the study was to determine the efficacy of carbapenem-only combination treatments derived from four approved drugs (meropenem, doripenem, ertapenem and imipenem) against a MDR strain of P.
Brendan Mackay, Benjamin J. Parcell, Sally L. Shirran, Peter J. Coote   +3 more
doaj   +1 more source

Safety of Intravenous Infusion of Doripenem [PDF]

Clinical Infectious Diseases, 2009
Carbapenems remain a mainstay for the empirical treatment of serious nosocomial infection. Although the tolerance and safety profile of the carbapenems as a class is favorable, the primary safety concern is the potential for treatment-emergent seizures. In preclinical testing, doripenem, a new carbapenem antibiotic, showed negligible neurotoxic effects.
Rebecca, Redman, Thomas M, File
openaire   +2 more sources

Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit [PDF]

, 2015
Doripenem has been recently introduced in Malaysia and is used for severe infections in the intensive care unit. However, limited data currently exist to guide optimal dosing in this scenario.
Sulaiman, H., Mat-Nor, M.B., Abd Rahman, A.N., Wallis, S.C., Roberts, J.A., Abdul-Aziz, M.H., Staatz, C.E., Lipman, J.   +7 more
core   +3 more sources

Bench‐Stable Boryl Thianthrenium Dication Enables Aziridinyl Boronate Synthesis via Metal‐Free Late‐Stage Aziridination with Diverse Nitrogen Nucleophiles

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A bench‐stable boryl thianthrenium dication is synthesized via thianthrenation of vinyl MIDA boronate. This novel dication enables metal‐free, chemo‐, and diastereoselective late‐stage aziridination with diverse nitrogen nucleophiles. The strategic significance is further showcased by one‐pot electrochemical and asymmetric protocols and versatile ...
Veerabhadra R. Vulupala, Disni Gunasekera, Nagarjun R. Mallampudi, Ramy Yousef, Yusif I. Gyasi, Gopal R. Ramidi, Ifeoluwa Adedotun, Shiqing Xu   +7 more
wiley   +2 more sources

Predicting the Effects of Carbapenem/Carbapenemase Inhibitor Combinations against KPC-Producing Klebsiella pneumoniae in Time-Kill Experiments: Alternative versus Traditional Approaches to MIC Determination

Antibiotics, 2021
Traditionally, the antibacterial activity of β-lactam antibiotics in the presence of β-lactamase inhibitors is determined at the fixed inhibitor concentration.
Alla V. Filimonova, Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Anastasiya A. Kuznetsova, Stephen H. Zinner   +5 more
doaj   +1 more source

In vitro Evaluation of Linezolid and Doripenem Clearance with Different Hemofilters

Blood Purification, 2020
Introduction: Renal replacement therapy (RRT) is widely used in the treatment of septic acute kidney injury. However, little is known about how the adsorption properties of hemofilters used in RRT affect antibiotic concentration.
Toshihisa Hiraiwa, K. Moriyama, Kana Matsumoto, Y. Shimomura, Yu Kato, Chizuru Yamashita, Yoshitaka Hara, T. Kawaji, Yasuyoshi Kurimoto, Tomoyuki Nakamura, Naohide Kuriyama, J. Shibata, H. Komura, Kunihiko Morita, O. Nishida   +14 more
semanticscholar   +1 more source

Doripenem

Drugs in R & D, 2003
Doripenem [S 4661] is a new parenteral carbapenem antibacterial undergoing clinical trials in Japan and North America. It is characterised by a 1beta-methyl group and a sulfamoylaminomethyl substituted pyrrolidylthio group at the C2 position. The compound has good activity against both Gram-positive and Gram-negative bacteria and superior activity to ...
openaire   +2 more sources

A Novel Reverse Phase HPLC Method for the Quantification of Potential Genotoxic Impurities in Doripenem Monohydrate: A Broad-Spectrum Carbapenem Antibiotic Drug

, 2021
A novel sensitive gradient reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the quantification of potential genotoxic impurities in doripenem monohydrate (DORIBAX) drug substance, namely mono-p ...
Sudhakar Yerra, P. K. Babu, B. Sreenivasulu, H. Sharma, K. Naidu, B. V. Rao   +5 more
semanticscholar   +1 more source

Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin in Pseudomonas aeruginosa

Canadian Journal of Infectious Diseases and Medical Microbiology, 2009
BACKGROUND: With a limited number of available antimicrobial agents to treat Pseudomonas aeruginosa infections, the prevention of emergence of antimicrobial resistance and its subsequent spread is critical.
George G Zhanel, Vibhu Vishisht, Ed Tam, Daryl J Hoban, James A Karlowsky   +4 more
doaj   +1 more source

Intereactions between doripenem and clavulanate — Application of minimal inhibitory concentration analysis and cytometry flow for bactericidal studies

Electronic Journal of Biotechnology, 2018
Background: In view of the current low efficacy of bacterial infection treatment the common trend towards searching for antibiotic systems exhibiting synergistic action is well justified.
Katarzyna Ciemniak, Judyta Cielecka-Piontek, Daria Szymanowska, Gabriela Wiergowska   +3 more
doaj   +1 more source