Results 31 to 40 of about 5,549 (198)
Journal of Pharmaceutical Health Care and Sciences, 2019 Background Despite the high mortality of patients with sepsis and carbapenem-resistant bacteria infection, appropriate antimicrobial therapies are yet to be established.
Kazutaka Oda +7 more
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Safety of Intravenous Infusion of Doripenem [PDF]
Clinical Infectious Diseases, 2009 Carbapenems remain a mainstay for the empirical treatment of serious nosocomial infection. Although the tolerance and safety profile of the carbapenems as a class is favorable, the primary safety concern is the potential for treatment-emergent seizures. In preclinical testing, doripenem, a new carbapenem antibiotic, showed negligible neurotoxic effects.
Rebecca, Redman, Thomas M, File
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Association of doripenem resistance with OXA-type carbapenemases in Acinetobacter baumannii isolates [PDF]
, 2016 Conclusion: The bla(OXA-23) and bla(OXA-58) gene combinations may confer resistance with a much greater MIC of both meropenem and doripenem.
Gulsah Asik +5 more
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Preparation and Characterization of Doripenem-Loaded Microparticles for Pulmonary Delivery
, 2018 Background: Pneumonia is a bacterial lower respiratory tract infection that has a high morbidity rate. The gram-negative pathogen Pseudomonas aeruginosa is a significant cause of nosocomial infections and ventilator-associated pneumonias and is mainly ...
Ayca Yildiz-Peköz +13 more
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Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit [PDF]
, 2015 Doripenem has been recently introduced in Malaysia and is used for severe infections in the intensive care unit. However, limited data currently exist to guide optimal dosing in this scenario.
Sulaiman, H. +7 more
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Doripenem: A new carbapenem antibiotic a review of comparative antimicrobial and bactericidal activities [PDF]
, 2007 Doripenem is a new parental 1-β-methyl carbapenem which, unlike imipenem, does not require the addition of cilastatin on administration because of the protection afforded to doripenem by the 1-β-methyl component.
Walsh, Fiona
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In vitro and in vivo efficacy study of cefepime, doripenem, tigecycline, and tetracycline against extended-spectrum beta-lactamases Escherichia coli in chickens [PDF]
Veterinary World, 2020 Background and Aim: At present, there are no data about the efficacy of some recent antibiotics on Escherichia coli in broiler chickens in the study area.
Yaser Hamadeh Tarazi +3 more
doaj +1 more source
Antibiotics, 2021 Traditionally, the antibacterial activity of β-lactam antibiotics in the presence of β-lactamase inhibitors is determined at the fixed inhibitor concentration.
Alla V. Filimonova +5 more
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Drugs in R & D, 2003 Doripenem [S 4661] is a new parenteral carbapenem antibacterial undergoing clinical trials in Japan and North America. It is characterised by a 1beta-methyl group and a sulfamoylaminomethyl substituted pyrrolidylthio group at the C2 position. The compound has good activity against both Gram-positive and Gram-negative bacteria and superior activity to ...
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A meta-analysis of efficacy and safety of doripenem for treating bacterial infections
Brazilian Journal of Infectious Diseases, 2015 Objective: The aim of this article is to compare the efficacy and safety of doripenem for bacterial infections. Methods: We included six randomized clinical trials identified from PubMed and Embase up to July 31, 2014.
Xiao-Yu Qu, Ting-Ting Hu, Wei Zhou
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