Results 11 to 20 of about 6,860 (236)
Antibiotics, 2022 The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy Chinese subjects and evaluate the optimal dosage regimens of doripenem.
Yu Wang +13 more
doaj +3 more sources
Fingolimod Promotes Antibacterial Effect of Doripenem against Carbapenem-Resistant Escherichia coli
Antibiotics, 2022 The aim of this study was to determine whether fingolimod could synergize the antibacterial activity of doripenem against carbapenem-resistant Escherichia coli (CREC) and its potential as an antibiotic adjuvant for doripenem. The E.
Hye-Won Jin, Hye-Rim Kim, Yong-Bin Eom
doaj +3 more sources
Journal of Microbiology, Immunology and Infection, 2019 Background: Doripenem shows good in vitro activity against common nosocomial pathogens, such as extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Wang-Da Liu +2 more
exaly +4 more sources
Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem
Antibiotics, 2019 Carbapenem-resistant Enterobacteriaceae are a significant threat to public health, and a major resistance determinant that promotes this phenotype is the production of the OXA-48 carbapenemase.
Krisztina M. Papp-Wallace +4 more
doaj +3 more sources
Synergistic Effect of Doripenem and Cefotaxime to Inhibit CTX-M-15 Type β-Lactamases: Biophysical and Microbiological Views [PDF]
Frontiers in Pharmacology, 2017 CTX-M-15 type β-lactamase has the ability to hydrolyse cefotaxime, a third generation cephalosporin. The infections caused by multidrug resistant strains, especially CTX-M-15 producing strains are being treated with carbapenem group of β-lactam ...
Lubna Maryam, Asad U. Khan
doaj +3 more sources
Clinical Infectious Diseases, 2009 Carbapenems play a significant role in the current antibiotic armamentarium. Doripenem is the newest carbapenem to be commercially released. Its antimicrobial spectrum more closely resembles those of meropenem and imipenem than that of ertapenem. Thus, it has significant in vitro activity against streptococci, methicillin-susceptible staphylococci ...
Paterson, David L., DePestel, Daryl D.
core +7 more sources
Antibiotics, 2023 The emergence of bacteria resistant to beta-lactam/beta-lactamase inhibitor combinations is insufficiently studied, wherein the role of the inoculum effect (IE) in decreased efficacy is unclear.
Elena N. Strukova +4 more
doaj +2 more sources
Doripenem in the Treatment of Patients with Nosocomial Pneumonia: A Meta-Analysis
Journal of Clinical Medicine, 2022 Introduction: Clinically, doripenem therapy for nosocomial pneumonia remains a serious concern. The purpose of this meta-analysis was to explore the efficacy and the safety of doripenem therapy for nosocomial pneumonia in comparison with other ...
Chienhsiu Huang, I. Chen, Ya-li Yang
semanticscholar +2 more sources
Pleural fluid penetration of moxifloxacin and doripenem: An experimental model of empyema [PDF]
İstanbul Kuzey Klinikleri, 2020 OBJECTIVE: This study aimed to evaluate the penetration of moxifloxacin and doripenem into the pleural fluid (PF) using a rabbit model of empyema. METHODS: An empyema was induced using the intrapleural injection of turpentine (1 mL), followed 24 h later ...
Mustafa Calik +4 more
doaj +2 more sources
Clinical Experience of Patients Receiving Doripenem-Containing Regimens for the Treatment of Healthcare-Associated Infections. [PDF]
PLoS ONE, 2016 In this study, we retrospectively reviewed the clinical experience of patients receiving doripenem-containing regimens for the treatment of healthcare-associated infections (HCAIs) in a tertiary care center and assessed the clinical usefulness of ...
Chien-Ming Chao +5 more
doaj +2 more sources