Results 11 to 20 of about 5,549 (198)

Pleural fluid penetration of moxifloxacin and doripenem: An experimental model of empyema [PDF]

İstanbul Kuzey Klinikleri, 2020
OBJECTIVE: This study aimed to evaluate the penetration of moxifloxacin and doripenem into the pleural fluid (PF) using a rabbit model of empyema. METHODS: An empyema was induced using the intrapleural injection of turpentine (1 mL), followed 24 h later ...
Mustafa Calik, Saniye Goknil Calik, Mustafa Dagli, Recep Kesli, Hidir Esme   +4 more
doaj   +2 more sources

Characterization of the antibiotic doripenem using physicochemical methods: chromatography, spectrophotometry, spectroscopy and thermal analysis [PDF]

Química Nova, 2011
Doripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were found to be adequate to identify the drug.
Andreas S. L Mendez, Luciano Mantovani, Fábio Barbosa, Carla T. M Sayago, Cássia V Garcia, Fávero R Paula, Fabiana E. B. da Silva, Elton L. G Denardin, Elfrides E. S Schapoval   +8 more
doaj   +4 more sources

Clinical Experience of Patients Receiving Doripenem-Containing Regimens for the Treatment of Healthcare-Associated Infections. [PDF]

PLoS ONE, 2016
In this study, we retrospectively reviewed the clinical experience of patients receiving doripenem-containing regimens for the treatment of healthcare-associated infections (HCAIs) in a tertiary care center and assessed the clinical usefulness of ...
Chien-Ming Chao, Chi-Chung Chen, Hui-Ling Huang, Yin-Ching Chuang, Chih-Cheng Lai, Hung-Jen Tang   +5 more
doaj   +2 more sources

Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem

Antibiotics, 2019
Carbapenem-resistant Enterobacteriaceae are a significant threat to public health, and a major resistance determinant that promotes this phenotype is the production of the OXA-48 carbapenemase.
Krisztina M. Papp-Wallace, Vijay Kumar, Elise T. Zeiser, Scott A. Becka, Focco van den Akker   +4 more
doaj   +2 more sources

Synergistic Effect of Doripenem and Cefotaxime to Inhibit CTX-M-15 Type β-Lactamases: Biophysical and Microbiological Views [PDF]

Frontiers in Pharmacology, 2017
CTX-M-15 type β-lactamase has the ability to hydrolyse cefotaxime, a third generation cephalosporin. The infections caused by multidrug resistant strains, especially CTX-M-15 producing strains are being treated with carbapenem group of β-lactam ...
Lubna Maryam, Asad U. Khan
doaj   +2 more sources

Doripenem in hospital infections: a focus on nosocomial pneumonia, complicated intra-abdominal infections, and complicated urinary tract infections

Infection and Drug Resistance, 2009
Tze Shien Lo,1 Stephanie M Borchardt,2 Justin M Welch,3 Melissa A Rohrich,3 Augusto M Alonto,4 Anne V Alonto51Infectious Diseases Service, Veterans Administration Medical Center, Fargo, North Dakota, USA; 2Research Service, Veterans ...
Tze Shien Lo, Stephanie M Borchardt, Justin M Welch, Melissa A Rohrich, Augusto M Alonto, Anne V Alonto   +5 more
doaj   +1 more source

Actividad comparativa in vitro de doripenem y de otros carbapenemes frente a Pseudomonas aeruginosa In vitro activity of doripenem and other carbapenems against Pseudomonas aeruginosa

Revista Argentina de Microbiología, 2010
Según estudios previos, el nuevo carbapeneme doripenem sería más activo frente a Pseudomonas aeruginosa en comparación con otros carbapenemes. En este estudio evaluamos la actividad in vitro del doripenem, el meropenem y el imipenem frente a 93 ...
F. Nicola, D. García Ramírez, S. Arduino, M. Di Chiara, J. Smayevsky   +4 more
doaj   +1 more source

Characteristics of doripenem: a new broad-spectrum antibiotic

Drug Design, Development and Therapy, 2009
Francisco Alvarez-Lerma1, Santiago Grau2, Olivia Ferrández21Intensive Care Unit, 2Pharmacy Department, Hospital Del Mar, Barcelona, SpainAbstract: Doripenem (S-4661) is a new parenteral antibiotic from the carbapenem class; similarly to ...
Francisco Alvarez-Lerma, Santiago Grau, Olivia Ferrández   +2 more
doaj   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP-MALDI Mass Spectrometry Biotyping. [PDF]

Adv Sci (Weinh)
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Adair LR, Iyer S, Jones IM, Cramer R.
europepmc   +2 more sources

Antimicrobial Resistance of Serratia marcescens Recovered From Aquatic Environments: A Review. [PDF]

Environ Microbiol Rep
Serratia marcescens is a gram‐negative bacillus forming biofilms and showing multidrug resistance. Review (2019–2024) included 13 studies, 90 aquatic isolates. High resistance to β‐lactams, including carbapenems. Genes: blaOXA‐48, blaTEM‐1, aac(6′)‐Ic. Aquatic environments are reservoirs, requiring monitoring and control to prevent spread.
Inacio HS, Santos YRS, de Paiva MC, Ferreira JMS.   +3 more
europepmc   +2 more sources