The Evaluation of Machine Learning Models Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) Spectra for the Prediction of Antibiotic Resistance in Klebsiella pneumoniae. [PDF]
MicrobiologyopenMachine learning models developed from matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry spectra can rapidly predict antimicrobial resistance in Klebsiella pneumoniae. By transforming routine spectral data into accurate resistance profiles within minutes, this approach could reduce diagnostic delays and support earlier ...
Fordham SME.
europepmc +2 more sources
In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model [PDF]
, 2011 Doripenem is a carbapenem antibiotic with broad-spectrum coverage of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa, and is considered to be as effective as meropenem.
Yamada, Koichi +13 more
core +2 more sources
Biofilm Formation in Clinical <i>Acinetobacter baumannii</i> Is Influenced by Isolate Source and Is Inversely Correlated With Antibiotic Resistance. [PDF]
Biomed Res IntAcinetobacter baumannii is a troublesome bacterium that is highly prevalent in hospital settings, particularly in intensive care units (ICUs). Biofilm is one of the main virulence factors that makes A. baumannii a successful pathogen, enabling it to survive the harshest environments.
Ababneh Q +8 more
europepmc +2 more sources
Antibiotics, 2022 In the context of difficult-to-treat carbapenem-resistant Pseudomonas aeruginosa infections, we evaluated imipenem, meropenem, and doripenem combinations against eleven carbapenemase-producing P. aeruginosa isolates.
Soraya Herrera-Espejo +8 more
doaj +1 more source
Biomedicines, 2022 The inoculum effect (IE) is a well-known phenomenon with beta-lactams. At the same time, the IE has not been extensively studied with carbapenem/carbapenemase inhibitor combinations.
Maria V. Golikova +7 more
doaj +1 more source
THE RADIOLYTIC STUDIES OF DORIPENEM MONOHYDRATE IN THE SOLID STATE [PDF]
, 2018 The influence of ionising radiation on physicochemical properties of doripenem in solid state was studied. No changes for doripenem irradiated with a dose of 25 kGy, required to attain sterility, was observed by FT-IR and chromatographic methods ...
Bednarski, Waldemar +6 more
core +1 more source
Doripenem: A new carbapenem in clinical practice [Doripenem: Klinik uygulamada yeni bir karbapenem]
, 2010 Doripenem is the newest addition to the carbapenems, the most active class of antibiotics against many resistant pathogens. This review focuses on the antimicrobial, pharmacological and clinical aspects of doripenem.
KORTEN, VOLKAN
core +2 more sources
Influence of Continuous Venovenous Hemofiltration and Continuous Venovenous Hemodiafiltration on the Disposition of Doripenem [PDF]
, 2011 The pharmacokinetics, safety, and tolerability of a single 1-hour, 500-mg intravenous infusion of doripenem were assessed in dialysis-dependent subjects with stage 5 chronic kidney disease undergoing continuous renal replacement therapy (CRRT) via 12 ...
Cirillo, Iolanda +9 more
core +1 more source
Antibiotics, 2022 The aim of the study was to determine the efficacy of carbapenem-only combination treatments derived from four approved drugs (meropenem, doripenem, ertapenem and imipenem) against a MDR strain of P.
Brendan Mackay +3 more
doaj +1 more source
Doripenem in the Treatment of Patients with Nosocomial Pneumonia: A Meta-Analysis
, 2022 Introduction: Clinically, doripenem therapy for nosocomial pneumonia remains a serious concern. The purpose of this meta-analysis was to explore the efficacy and the safety of doripenem therapy for nosocomial pneumonia in comparison with other ...
Chienhsiu Huang +5 more
core +1 more source