Results 21 to 30 of about 6,860 (236)

Gut Microbiota as Well as Metabolomes of Wistar Rats Recover within Two Weeks after Doripenem Antibiotic Treatment

Microorganisms, 2023
An understanding of the changes in gut microbiome composition and its associated metabolic functions is important to assess the potential implications thereof on host health.
Aishwarya Murali, Franziska Maria Zickgraf, Philipp Ternes, Varun Giri, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk Weyer, Shana J. Sturla, Ivonne M. G. M. Rietjens, Bennard van Ravenzwaay   +12 more
doaj   +2 more sources

Characterization of the antibiotic doripenem using physicochemical methods: chromatography, spectrophotometry, spectroscopy and thermal analysis [PDF]

Química Nova, 2011
Doripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were found to be adequate to identify the drug.
Andreas S. L Mendez, Luciano Mantovani, Fábio Barbosa, Carla T. M Sayago, Cássia V Garcia, Fávero R Paula, Fabiana E. B. da Silva, Elton L. G Denardin, Elfrides E. S Schapoval   +8 more
doaj   +2 more sources

Preparation and Characterization of Doripenem-Loaded Microparticles for Pulmonary Delivery

Journal of Aerosol Medicine, 2018
Background: Pneumonia is a bacterial lower respiratory tract infection that has a high morbidity rate. The gram-negative pathogen Pseudomonas aeruginosa is a significant cause of nosocomial infections and ventilator-associated pneumonias and is mainly ...
Ayca Yıldız-Peköz, O. Akbal, Ş. H. Tekarslan, A. Sağırlı, L. Mulazımoglu, D. Morina, E. Cevher   +6 more
semanticscholar   +3 more sources

In vitro and in vivo efficacy study of cefepime, doripenem, tigecycline, and tetracycline against extended-spectrum beta-lactamases Escherichia coli in chickens [PDF]

Veterinary World, 2020
Background and Aim: At present, there are no data about the efficacy of some recent antibiotics on Escherichia coli in broiler chickens in the study area.
Yaser Hamadeh Tarazi, Ehab A. Abu-Basha, Zuhair Bani Ismail, Rawan A. Tailony   +3 more
doaj   +2 more sources

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa [PDF]

Microbiology Spectrum
The ftsI locus of gram-negative bacteria encodes penicillin-binding protein 3 (PBP3), a common target of β-lactam antibiotics. Recent genomic surveillance of carbapenem-resistant Pseudomonas aeruginosa revealed that 17% of strains possessed nonsynonymous
Hirokazu Yano, Noboru Nakata, Koji Yahara, Motoyuki Sugai, Yukari Sato   +4 more
doaj   +2 more sources

Doripenem in hospital infections: a focus on nosocomial pneumonia, complicated intra-abdominal infections, and complicated urinary tract infections

Infection and Drug Resistance, 2009
Tze Shien Lo,1 Stephanie M Borchardt,2 Justin M Welch,3 Melissa A Rohrich,3 Augusto M Alonto,4 Anne V Alonto51Infectious Diseases Service, Veterans Administration Medical Center, Fargo, North Dakota, USA; 2Research Service, Veterans ...
Tze Shien Lo, Stephanie M Borchardt, Justin M Welch, Melissa A Rohrich, Augusto M Alonto, Anne V Alonto   +5 more
doaj   +1 more source

Continuous high-dose infusion of doripenem in a pneumonia patient infected by carbapenem-resistant Pseudomonas aeruginosa: a case report

Journal of Pharmaceutical Health Care and Sciences, 2019
Background Despite the high mortality of patients with sepsis and carbapenem-resistant bacteria infection, appropriate antimicrobial therapies are yet to be established.
Kazutaka Oda, Hidenobu Kamohara, Tomomi Katanoda, Yumi Hashiguchi, Koji Iwamura, Kisato Nosaka, Hirofumi Jono, Hideyuki Saito   +7 more
doaj   +2 more sources

A meta-analysis of efficacy and safety of doripenem for treating bacterial infections

Brazilian Journal of Infectious Diseases, 2015
Objective: The aim of this article is to compare the efficacy and safety of doripenem for bacterial infections. Methods: We included six randomized clinical trials identified from PubMed and Embase up to July 31, 2014.
Xiao-Yu Qu, Ting-Ting Hu, Wei Zhou
doaj   +2 more sources

Characteristics of doripenem: a new broad-spectrum antibiotic

Drug Design, Development and Therapy, 2009
Francisco Alvarez-Lerma1, Santiago Grau2, Olivia Ferrández21Intensive Care Unit, 2Pharmacy Department, Hospital Del Mar, Barcelona, SpainAbstract: Doripenem (S-4661) is a new parenteral antibiotic from the carbapenem class; similarly to ...
Francisco Alvarez-Lerma, Santiago Grau, Olivia Ferrández   +2 more
doaj   +1 more source

Doripenem

Drugs of Today, 2006
Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens similar to imipenem and, especially, meropenem. This parenteral antibiotic may offer slightly more activity than meropenem against selected pathogens, including coverage of some strains of ...
europepmc   +3 more sources