Results 11 to 20 of about 26,814 (193)

Dorsoventral patterning in hemichordates: insights into early chordate evolution. [PDF]

PLoS Biology, 2006
We have compared the dorsoventral development of hemichordates and chordates to deduce the organization of their common ancestor, and hence to identify the evolutionary modifications of the chordate body axis after the lineages split. In the hemichordate
Christopher J Lowe, Mark Terasaki, Michael Wu, Robert M Freeman, Linda Runft, Kristen Kwan, Saori Haigo, Jochanan Aronowicz, Eric Lander, Chris Gruber, Mark Smith, Marc Kirschner, John Gerhart   +12 more
doaj   +5 more sources

Evolution of Development: Diversified Dorsoventral Patterning [PDF]

Current Biology, 2011
Patterning of the dorsoventral axis by graded BMP signaling is conserved in the evolution of animals. However, this system has also proven to be highly adaptable, as is now highlighted by its short-range function in the leech Helobdella.
Ethan Bier, Bier, Ethan
openaire   +3 more sources

Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing

iScience, 2023
Summary: The spinal cord possesses highly complex, finely organized cytoarchitecture guided by two dorsoventral morphogenic organizing centers. Thus, generation of human spinal cord tissue in vitro is challenging. Here, we demonstrated a novel method for
Weiwei Xue, Bo Li, Huihui Liu, Yujie Xiao, Bo Li, Lei Ren, Huijuan Li, Zhicheng Shao   +7 more
doaj   +2 more sources

Ciglitazone—a human PPARγ agonist—disrupts dorsoventral patterning in zebrafish [PDF]

PeerJ, 2019
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that regulates lipid/glucose homeostasis and adipocyte differentiation.
Vanessa Cheng, Subham Dasgupta, Aalekhya Reddam, David C. Volz   +3 more
doaj   +4 more sources

Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning.

PLoS ONE, 2011
Formation of a dorsoventral axis is a key event in the early development of most animal embryos. It is well established that bone morphogenetic proteins (Bmps) and Wnts are key mediators of dorsoventral patterning in vertebrates.
Iryna Kozmikova, Jana Smolikova, Cestmir Vlcek, Zbynek Kozmik   +3 more
doaj   +2 more sources

Eph regulates dorsoventral asymmetry of the notochord plate and convergent extension-mediated notochord formation. [PDF]

PLoS ONE, 2010
The notochord is a signaling center required for the patterning of the vertebrate embryonic midline, however, the molecular and cellular mechanisms involved in the formation of this essential embryonic tissue remain unclear.
Izumi Oda-Ishii, Yasuo Ishii, Takashi Mikawa   +2 more
doaj   +2 more sources

Spreading depolarization is followed by seizure-like activation of the hippocampus: potential mechanism of migraine-aura triggered seizures [PDF]

The Journal of Headache and Pain
Background Propagation of spreading depolarization (SD), a wave of transient cellular depolarization, over the cerebral cortex drives migraine aura symptoms.
Maria P. Smirnova, Irina V. Pavlova, Lyudmila V. Vinogradova   +2 more
doaj   +2 more sources

Serotonin Modulation of Dorsoventral Hippocampus in Physiology and Schizophrenia

International Journal of Molecular Sciences
The serotonergic system, originating in the raphe nuclei, differentially modulates the dorsal and ventral hippocampus, which are implicated in cognition and emotion, respectively. Emerging evidence from rodent models (e.g., neonatal ventral hippocampal lesion, pharmacological NMDA receptor antagonist exposure) and human postmortem studies indicates ...
Charalampos L. Kandilakis, Costas Papatheodoropoulos   +1 more
openaire   +4 more sources

Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome

Frontiers in Cellular Neuroscience, 2023
Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by intellectual disability and is related to autism. FXS is caused by mutations of the fragile X messenger ribonucleoprotein 1 gene (Fmr1) and is associated with alterations ...
Leonidas J. Leontiadis, George Trompoukis, Giota Tsotsokou, Athina Miliou, Panagiotis Felemegkas, Costas Papatheodoropoulos   +5 more
doaj   +1 more source

Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus

eLife, 2022
Local field potential (LFP) deflections and oscillations define hippocampal sharp-wave ripples (SWRs), one of the most synchronous events of the brain.
Andrea Navas-Olive, Rodrigo Amaducci, Maria-Teresa Jurado-Parras, Enrique R Sebastian, Liset M de la Prida   +4 more
doaj   +1 more source