Results 61 to 70 of about 14,179 (253)

Self-assembly and DNA binding of the blocking factor in X chromosome inactivation [PDF]

, 2007
X chromosome inactivation (XCI) is the phenomenon occurring in female mammals whereby dosage compensation of X-linked genes is obtained by transcriptional silencing of one of their two X chromosomes, randomly chosen during early embryo development. The
Prisco, Antonella, Nicodemi, Mario, Antonella Prisco, Nicodemi Mario, Nicodemi M., Mario Nicodemi, Prisco Antonella, Prisco A.   +7 more
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Heterosis of growth trait regulated by DNA methylation and miRNA in allotriploid fish

Epigenetics & Chromatin, 2022
Background Heterosis of growth traits in allotriploid fish has benefited the production of aquaculture for many years, yet its genetic and molecular basis has remained obscure.
Li Ren, Hong Zhang, Mengxue Luo, Xin Gao, Jialin Cui, Xueyin Zhang, Shaojun Liu   +6 more
doaj   +1 more source

The Effect of Hybridization on Dosage Compensation in Member Species of theAnopheles gambiaeSpecies Complex

, 2018
Dosage compensation has evolved in concert with Y-chromosome degeneration in many taxa that exhibit heterogametic sex chromosomes. Dosage compensation overcomes the biological challenge of a "half dose" of X chromosome gene transcripts in the ...
Michel A. Slotman, Kevin C. Deitz, Willem Takken   +2 more
core   +1 more source

The value of avian genomics to the conservation of wildlife [PDF]

, 2009
Background: Genomic studies in non-domestic avian models, such as the California condor and white-throated sparrow, can lead to more comprehensive conservation plans and provide clues for understanding mechanisms affecting genetic variation, adaptation ...
Hickenbotham, Matthew T, Mardis, Elaine R., Dandekar, Sugandha, Modi, William S, Modi, William S., Jones, Kenneth C., Papp, Jeanette C, Mardis, Elaine R, Glasscock, Jarret, Houck, Marlys L, Green, Eric D, Chemnick, Leona G., Otten, Christie A, Stremel Mork, Emily M., Green, Eric D., Chemnick, Leona G, Stremel Mork, Emily M, Papp, Jeanette C., Romanov, Michael N, Magrini, Vincent, Ryder, Oliver A, Hickenbotham, Matthew T., NISC Comparative Sequencing Program,, Otten, Christie A., Tuttle, Elaina M., Tuttle, Elaina M, Houck, Marlys L., Korody, Marisa L, Renner, Tanya, Jones, Kenneth C, Da, Yang, McGrath, Sean, Korody, Marisa L., Ryder, Oliver A.   +33 more
core   +1 more source

COVID‐19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans

Arthritis Care &Research, EarlyView.
Objective Several case reports have proposed a potential association between COVID‐19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID‐19 vaccination in US veterans who developed new‐onset IIM compared to those without new‐onset IIM.
Caleb Hernández, Naomi Schlesinger, Jorge Rojas, Jessica A. Walsh, Tawnie J. Braaten, Gary A. Kunkel, Makoto Jones, Brian C Sauer, Julio Facelli, Grant W. Cannon, Dorota Lebiedz‐Odrobina   +10 more
wiley   +1 more source

Protein expression reveals a molecular sexual identity of avian primordial germ cells at pre-gonadal stages

Scientific Reports, 2021
In poultry, in vitro propagated primordial germ cells (PGCs) represent an important tool for the cryopreservation of avian genetic resources. However, several studies have highlighted sexual differences exhibited by PGCs during in vitro propagation ...
Laura Soler, Sabine Alves, Aurélien Brionne, Aurore Jacques, Vanessa Guérin, Maeva Cherif-Feildel, Lucie Combes-Soia, Sophie Fouchécourt, Aurore Thélie, Elisabeth Blesbois, Michael J. McGrew, Valérie Labas, Marina S. Govoroun   +12 more
doaj   +1 more source

The SMC family: from chromosome condensation to dosage compensation

, 1995
Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis.
Swedlow, Jason R; id_orcid, Tatsuya Hirano, Hirano, Tatsuya, Mitchison, Timothy J, Timothy J Mitchison, Jason R Swedlow   +5 more
core   +1 more source

Designing Polymer Nanocomposites for X‐Ray Shielding: Mechanisms, Architectures, and Scalable Processing

Advanced Engineering Materials, EarlyView.
This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele, Hossein Ipakchi, Tizazu H. Mekonnen   +2 more
wiley   +1 more source

X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Stem Cell Reports, 2019
Summary: Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female iPSCs compared with male iPSCs leads to differences ...
Juan Song, Adrian Janiszewski, Natalie De Geest, Lotte Vanheer, Irene Talon, Mouna El Bakkali, Taeho Oh, Vincent Pasque   +7 more
doaj   +1 more source