Results 51 to 60 of about 1,326,462 (264)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Beyond two-stage models for lung carcinogenesis in the Mayak workers: Implications for Plutonium risk

, 2015
Mechanistic multi-stage models are used to analyze lung-cancer mortality after Plutonium exposure in the Mayak-workers cohort, with follow-up until 2008.
Eidemüller, Markus, Sokolnikov, Mikhail E., Zöllner, Sascha   +2 more
core   +2 more sources

The association between perceived stress and mortality among people with multimorbidity: a prospective population-based cohort study [PDF]

, 2016
Multimorbidity is common and is associated with poor mental health and high mortality. Nevertheless, no studies have evaluated whether mental health may affect the survival of people with multimorbidity.
Christensen, Kaj Sparle, Fenger-Grøn, Morten, Larsen, Finn Breinholt, Larsen, Karen Kjær, Mercer, Stewart W., Nielsen, Marie Germund, Prior, Anders, Robinson, Kirstine Magtengaard, Vestergaard, Mogens   +8 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Correlation between cardiometabolic index and stroke in middle-aged and older adults

Zhongguo linchuang yanjiu
Objective To explore the relationship between cardiac metabolic index (CMI) and stroke in middle-aged and elderly individuals based on a large sample cohort study. Methods Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS)
YU Yang, SHA Ou
doaj   +1 more source

A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe

Frontiers in Pharmacology, 2021
Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control.
Jeroen V. Koomen, Jeroen V. Koomen, Jasper Stevens, Margje H. Monster-Simons, Margje H. Monster-Simons, Hiddo J. L. Heerspink, Peter G. M. Mol, Peter G. M. Mol   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dose-response relationship and low dose extrapolatioin in chemical carcinogenesis [PDF]

, 2017
Data supporting various dose-response relationships in chemical carcinogenesis are summarized. General principles are derived to explain the relationships between exposure dose, DNA adduct level, induction of genetic changes, and tumor incidence.
Lutz, Werner K.
core  

A Nonparametric Method for the Derivation of α/β Ratios from the Effect of Fractionated Irradiations [PDF]

, 1991
Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence.
A.M. Kellerer, D. Chmelevsky, Douglas B.G., Douglas B.G., Efron B, Efron B, Guttenberger R., Han A.K, Henkelman R.M., J. Kummermehr, Kellerer A.M., Kummermehr J., Lam G.K.Y., Maciejewski B., R. Guttenberger, Taylor J.M.G., Thames H.D, Tucker S.L, Vegesna V., Williams M.V.   +19 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source